DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17196 and ZDHHC1

DIOPT Version :9

Sequence 1:	NP_651426.1	Gene:	CG17196 / 43112	FlyBaseID:	FBgn0039368	Length:	276	Species:	Drosophila melanogaster
Sequence 2:	NP_037436.1	Gene:	ZDHHC1 / 29800	HGNCID:	17916	Length:	485	Species:	Homo sapiens

Alignment Length:	288	Identity:	56/288 - (19%)
Similarity:	101/288 - (35%)	Gaps:	71/288 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 HPLSVIFLLVSTVFFFTLQVFYVAPDV-HDGFMYKFFVISAIFTTYNILGNLLACYRTSSAVKSL 87
            |||.::..|: .:||..:....:.|.: |......:..:.|||.     |:|:.   ..:||...
Human    49 HPLQIVAWLL-YLFFAVIGFGILVPLLPHHWVPAGYACMGAIFA-----GHLVV---HLTAVSID 104

  Fly    88 PQERQI-------PKPGTEHLWH-------YCDICQKLMPPRSWHCALCKCCILKRDHHCIFAAT 138
            |.:..:       |.|......|       :|::|...:..||.||:.|..|:...||||.:...
Human   105 PADANVRDKSYAGPLPIFNRSQHAHVIEDLHCNLCNVDVSARSKHCSACNKCVCGFDHHCKWLNN 169

  Fly   139 CIGHNNHRYFFWLTFYLAFGIFM--SMAT-LFVD---------VGRSFYLLHR---------MKA 182
            |:|..|:|.|.........|:.:  .:|| :||:         ..|.|.:|..         ..|
Human   170 CVGERNYRLFLHSVASALLGVLLLVLVATYVFVEFFVNPMRLRTNRHFEVLKNHTDVWFVFLPAA 234

  Fly   183 GFGNTVKSLSYFRYVCLILNIFALGFPALMLRFQVQILKLNSTYYQISSRHHDLGFRNNCQLIMG 247
            .......::.....:.::|.:.:......:|.|.:.::....|.|:...:|
Human   235 PVETQAPAILALAALLILLGLLSTALLGHLLCFHIYLMWHKLTTYEYIVQH-------------- 285

  Fly   248 QRGLWTFISPSLRSPLPHDGTHWKIKQC 275
                        |.|....|.|.:::.|
Human   286 ------------RPPQEAKGVHRELESC 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17196	NP_651426.1	zf-DHHC	103..228	CDD:279823	31/152 (20%)
ZDHHC1	NP_037436.1	Mediates interaction with STING1. /evidence=ECO:0000269\|PubMed:25299331	1..271		48/230 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		zf-DHHC	129..284	CDD:307600	31/154 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..358
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810