DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17197 and Zdhhc2

DIOPT Version :9

Sequence 1:	NP_651425.2	Gene:	CG17197 / 43111	FlyBaseID:	FBgn0039367	Length:	290	Species:	Drosophila melanogaster
Sequence 2:	NP_848482.1	Gene:	Zdhhc2 / 70546	MGIID:	1923452	Length:	366	Species:	Mus musculus

Alignment Length:	339	Identity:	75/339 - (22%)
Similarity:	116/339 - (34%)	Gaps:	121/339 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 QMFYVVPQLFDVQGFMYKLGW------LVAIFITYNIFGNMLAC----HITST--------SVES 88
            ::.|.:|.:|    ....|||      :....::....|..:.|    |:...        ::.:
Mouse    15 RVLYWIPVVF----ISLLLGWSYYAYAIQLCIVSMENIGEQVVCLMAYHLLFAMFVWSYWKTIFT 75

  Fly    89 LP-----------KDRQIPEPE---EEHQ--------------------WHYCDVCEKLMPPRSW 119
            ||           .::::.|.|   |.||                    ..|||.|:.:.|.|..
Mouse    76 LPMNPSKEFHLSYAEKELLEREPRGEAHQEVLRRAAKDLPIYTRTMSGAIRYCDRCQLIKPDRCH 140

  Fly   120 HCILCKCCILKRDRHCIFTASCVGHNNQRYFFWFTLFMALGTGVALATHIIAT-LKYFSYSDLIF 183
            ||.:|..||||.|.||.:..:|||.:|.::|..|..:..|     ....|.|| |:||.   ..:
Mouse   141 HCSVCDKCILKMDHHCPWVNNCVGFSNYKFFLLFLAYSLL-----YCLFIAATDLQYFI---RFW 197

  Fly   184 LNIPRDNLPPFWLVITLILNTYVFAAPVSSVLMQLS---------VLKNNGTLHKFYS------- 232
            .|...|....|.::...      |||.:.||  .||         |.||..||..|.:
Mouse   198 TNGLPDTQAKFHIMFLF------FAAAMFSV--SLSSLFGYHCWLVSKNKSTLEAFRNPVFRHGT 254

  Fly   233 --DTYDLGLWENFKLILGG-KGFWTF-----------------------------LSPTVKSPLP 265
              :.:.||..:|.:.:.|. |.:|..                             |:.|||:|..
Mouse   255 DKNGFSLGFSKNMRQVFGDEKKYWLLPVFSSQGDGCSFPTCLVNQDPEQPSTPAGLNSTVKNPEN 319

  Fly   266 HDGAQWKIKRVQHH 279
            |......::..|.|
Mouse   320 HQFPAKPLRESQSH 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17197	NP_651425.2	PHA02688	<9..70	CDD:222919	6/33 (18%)
CG17197	NP_651425.2	zf-DHHC	100..>198	CDD:279823	35/118 (30%)
Zdhhc2	NP_848482.1	DHHC	126..247	CDD:366691	45/136 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	296..366		8/38 (21%)
		Mediates localization to plasma membrane and recycling endosomes. /evidence=ECO:0000269\|PubMed:21471008	298..366		8/36 (22%)
		Non-canonical dileucine endocytic signal. /evidence=ECO:0000269\|PubMed:28768144	334..335		75/339 (22%)
		NPxY-like endocytic signal. /evidence=ECO:0000269\|PubMed:28768144	357..360
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810