DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17197 and Zdhhc17

DIOPT Version :9

Sequence 1:	NP_651425.2	Gene:	CG17197 / 43111	FlyBaseID:	FBgn0039367	Length:	290	Species:	Drosophila melanogaster
Sequence 2:	NP_766142.2	Gene:	Zdhhc17 / 320150	MGIID:	2445110	Length:	632	Species:	Mus musculus

Alignment Length:	301	Identity:	71/301 - (23%)
Similarity:	116/301 - (38%)	Gaps:	88/301 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IWACTKYLARRNPKIFVRISHPTAVLFVIVTTIFFVVLQMFYVVPQLFDVQGFMYKLGWL----- 63
            :||..::|::   ..|....|....|.:.:.|.|::.:..|:         .|...|.:|
Mouse   338 VWATVQFLSK---SFFDHSMHSALPLGIYLATKFWMYVTWFF---------WFWNDLNFLFIHLP 390

  Fly    64 -----VAIFITYNIFGNMLACHITSTSVESLPKDRQIPEPEEEHQWH---------------YCD 108
                 ||:|  || ||            :|...|..|.:..||.:..               :|.
Mouse   391 FLANSVALF--YN-FG------------KSWKSDPGIIKATEEQKKKTIVELAETGSLDLSIFCS 440

  Fly   109 VCEKLMPPRSWHCILCKCCILKRDRHCIFTASCVGHNNQRYF---FWFTLFMALGTGVALATHII 170
            .|....|.||.||.:|..||.|.|.||.:..:|||..|.|||   .:|.|||       :...|.
Mouse   441 TCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLFFLLFM-------ICWMIY 498

  Fly   171 ATLKYF------SYSDLIFLNIPRDNLPPFWLVITLI--LNTYVFAAPVSSV--LMQLSVLKNNG 225
            ..:.|:      :|:        :|.   ||..||.|  .:.::|...::||  .:.::||
Mouse   499 GCVSYWGLHCETTYT--------KDG---FWTYITQIATCSPWMFWMFLNSVFHFLWVAVL---- 548

  Fly   226 TLHKFYSDTYDLGLWENFKLILGGKGFWTFLSPTVKSPLPH 266
            .:.:.|..|. ||:..|.::.......:...:.:::||..|
Mouse   549 LMCQLYQITC-LGITTNERMNARRYKHFKVTTTSIESPFNH 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17197	NP_651425.2	PHA02688	<9..70	CDD:222919	13/70 (19%)
CG17197	NP_651425.2	zf-DHHC	100..>198	CDD:279823	33/121 (27%)
Zdhhc17	NP_766142.2	Necessary and sufficient for interaction with DNAJC5 and SNAP25. /evidence=ECO:0000269\|PubMed:25253725	11..305
		ANK repeat	89..120	CDD:293786
		PHA03095	100..>352	CDD:222980	4/16 (25%)
		ANK repeat	122..154	CDD:293786
		ANK repeat	156..187	CDD:293786
		Ank_2	161..255	CDD:372319
		ANK repeat	189..221	CDD:293786
		ANK repeat	224..255	CDD:293786
		DHHC	438..568	CDD:366691	44/152 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810