DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17198 and Zdhhc2

DIOPT Version :9

Sequence 1:	NP_001287532.1	Gene:	CG17198 / 43110	FlyBaseID:	FBgn0039366	Length:	299	Species:	Drosophila melanogaster
Sequence 2:	NP_848482.1	Gene:	Zdhhc2 / 70546	MGIID:	1923452	Length:	366	Species:	Mus musculus

Alignment Length:	354	Identity:	67/354 - (18%)
Similarity:	117/354 - (33%)	Gaps:	132/354 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 IPRRVGAIKSWTDIMGVSINVCIILFFYFFEAFYVMPQFLG-----LFGQAVHFLVTTWIVYNIL 84
            :.||...:..|..::.:|:.:....:.|..:...|..:.:|     |....:.|.:..|..:.
Mouse     9 VRRRCRRVLYWIPVVFISLLLGWSYYAYAIQLCIVSMENIGEQVVCLMAYHLLFAMFVWSYWK-- 71

  Fly    85 ENLRLCVTTLNTVDSLPPQ-----------MQQPMKGEEH--------------------LWHFC 118
                    |:.|:...|.:           :::..:||.|                    ...:|
Mouse    72 --------TIFTLPMNPSKEFHLSYAEKELLEREPRGEAHQEVLRRAAKDLPIYTRTMSGAIRYC 128

  Fly   119 KICQRNVPPRSWHCNICDACILKRDHHCNFVGNCVGHNNQRYFIWFSFYAAIGSAVALFDNFMLA 183
            ..||...|.|..||::||.||||.||||.:|.||||.:|.::|:.|..|:.:
Mouse   129 DRCQLIKPDRCHHCSVCDKCILKMDHHCPWVNNCVGFSNYKFFLLFLAYSLL------------- 180

  Fly   184 HKHGVGFFDLVKANYIIFNAYMNPGRKELVIFYRI------VSVLGVNIFAVLFPAALFCTQV-- 240
                          |.:|.|     ..:|..|.|.      .:....:|..:.|.||:|...:
Mouse   181 --------------YCLFIA-----ATDLQYFIRFWTNGLPDTQAKFHIMFLFFAAAMFSVSLSS 226

  Fly   241 ---------------VTVIKNSVMHDYSDRT-YDLGLGNNLTLILG-SRRLW------------- 275
                           :...:|.|....:|:. :.||...|:..:.| .::.|
Mouse   227 LFGYHCWLVSKNKSTLEAFRNPVFRHGTDKNGFSLGFSKNMRQVFGDEKKYWLLPVFSSQGDGCS 291

  Fly   276 --TC--------------LSPNIKSPLPH 288
              ||              |:..:|:|..|
Mouse   292 FPTCLVNQDPEQPSTPAGLNSTVKNPENH 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17198	NP_001287532.1	zf-DHHC	43..>176	CDD:303066	38/168 (23%)
CG17198	NP_001287532.1	zf-DHHC	111..252	CDD:279823	41/183 (22%)
Zdhhc2	NP_848482.1	DHHC	126..247	CDD:366691	37/152 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	296..366		4/25 (16%)
		Mediates localization to plasma membrane and recycling endosomes. /evidence=ECO:0000269\|PubMed:21471008	298..366		4/23 (17%)
		Non-canonical dileucine endocytic signal. /evidence=ECO:0000269\|PubMed:28768144	334..335
		NPxY-like endocytic signal. /evidence=ECO:0000269\|PubMed:28768144	357..360
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810