DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17198 and ZDHHC15

DIOPT Version :9

Sequence 1:	NP_001287532.1	Gene:	CG17198 / 43110	FlyBaseID:	FBgn0039366	Length:	299	Species:	Drosophila melanogaster
Sequence 2:	NP_659406.1	Gene:	ZDHHC15 / 158866	HGNCID:	20342	Length:	337	Species:	Homo sapiens

Alignment Length:	293	Identity:	69/293 - (23%)
Similarity:	116/293 - (39%)	Gaps:	61/293 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 IKSWTDIMGVSINVCIILFFYFFEAFYV---MPQFLGLFGQAVH--FLVTTWIVYNIL------- 84
            :.||..::.:.:.|....:.|.||...|   .|....::....|  |:..||..:..:
Human    19 VLSWVPVLVIVLVVLWSYYAYVFELCLVTVLSPAEKVIYLILYHAIFVFFTWTYWKSIFTLPQQP 83

  Fly    85 -ENLRLCVTTLNTVDSLP-PQMQQPM------------KGEEHLWHFCKICQRNVPPRSWHCNIC 135
             :...|..|.....::.. |::|:.|            :.......||..|....|.|..||::|
Human    84 NQKFHLSYTDKERYENEERPEVQKQMLVDMAKKLPVYTRTGSGAVRFCDRCHLIKPDRCHHCSVC 148

  Fly   136 DACILKRDHHCNFVGNCVGHNNQRYFIWFSFYAAIGS---AVALFDNFMLAHKHGVGFFDLVKAN 197
            ..|:||.||||.:|.||:|.:|.::|:.|..|:.:..   |..:|..|:   |:..|....|::.
Human   149 AMCVLKMDHHCPWVNNCIGFSNYKFFLQFLAYSVLYCLYIATTVFSYFI---KYWRGELPSVRSK 210

  Fly   198 ----YIIFNAYMNPGRKELVIFYRIVSVLGVNIFAV---LFPAALFCTQVVT--VIKNSVMHDYS 253
                :::|.|.|        .|..:|.:.|.:.:.|   ......|||.|.|  ..||.
Human   211 FHVLFLLFVACM--------FFVSLVILFGYHCWLVSRNKTTLEAFCTPVFTSGPEKNG------ 261

  Fly   254 DRTYDLGLGNNLTLILG-SRRLWTCLSPNIKSP 285
               ::||...|:..:.| .::.|  |.|...||
Human   262 ---FNLGFIKNIQQVFGDKKKFW--LIPIGSSP 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17198	NP_001287532.1	zf-DHHC	43..>176	CDD:303066	39/161 (24%)
CG17198	NP_001287532.1	zf-DHHC	111..252	CDD:279823	43/152 (28%)
ZDHHC15	NP_659406.1	zf-DHHC	<126..308	CDD:327686	52/186 (28%)
ZDHHC15	NP_659406.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..337
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810