Protein Alignment MME and Nepl21

DIOPT Version :10

• Sequence 1: NP_000893.2
• Gene: MME / 4311
• HGNCID: 7154
• Length: 750
• Species: Homo sapiens
• Sequence 2: NP_651646.2
• Gene: Nepl21 / 43413
• FlyBaseID: FBgn0027578
• Length: 707
• Species: Drosophila melanogaster
• Alignment Length: 742
• Identity: 196/742 - (26%)
• Similarity: 335/742 - (45%)
• Gaps: 101/742 - (13%)

Human    45 MIALYATYDDGICKSSDCIKSAARLIQN------MDATTEPCTDFFKYACGGWLKRN-VIPETSS 102
            |:|...|.::.:.:.:..:|...|..:.      ||...:||.||:.::||.:.:.| .:.....
  Fly    25 MVAAAPTSEEDLKQDTPYMKELLRQAKTAEIESFMDQKADPCNDFYAFSCGNYKRINSALSMQVV 89

Human   103 RYGNFDILRDELEVVLKDVLQEP-----KTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLP 162
            ..|.|:.|...|...:..:|..|     ..|||    |.|..|.||:....::|...|.|.:|:.
  Fly    90 TTGVFETLTKGLNRKILKMLNTPHDSHDTPEDI----KVKHFYESCLQIKELNSTYSEKLKRLIA 150

Human   163 DIYGWPVATENWEQKYGASWTAE-----KAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQP 222
            :....|:..       |:||..:     ...|::..:||...:..:.|..|..::..:.|::.|.
  Fly   151 EFGTMPLLE-------GSSWQEDDFDWLNTTARMAYRYGITPIFGIEVNKDLASNTRNRIYLGQQ 208

Human   223 RLGLPSRDYY--ECTGIYKEACTAYVDFMISVARLIRQEERLPIDENQLALEMNK-VMELEKEIA 284
            ...|.:|..|  :.|.:|::      .:..::.|::::...:.:|   ||.:..| :::.|.::|
  Fly   209 DFPLEARSMYVDDATAVYRQ------KYRNNIQRILQRYLGVKMD---LAKKTAKELIDFEVDLA 264

Human   285 NATAKPEDRNDPMLLYNKMTLAQIQNNFS--LEINGKPFSWLNFTNEIMSTVNISITNEEDVVVY 347
            .......:..|...|...:|:.:||..:|  |:|:...|            |::.....:.:..|
  Fly   265 QGLVDESEGLDVGELTQLLTVDEIQRRYSPTLDIDRLLF------------VSMGERISDQIYEY 317

Human   348 APEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCA 412
            ...|...|..::.:...|.:.|.:.:|.|.:.|    .|..:|.....||....|.:
  Fly   318 NNRYQQNLVEVIKRTPKRTVANYIFFRLIWEFV----ETPSDSPEKQMKACVDLTKK-------- 370

Human   413 NYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDD---LTWMDAETKKRAEEKAL 474
             |...|::|...|.|...    :|...::::..|::..|.:||..   |.|::..|:..|..|..
  Fly   371 -YFAKNLDNMFYRRYNNE----KSSREIDNMWRQLKSTFNETLRSSPALNWIERPTRNLAMAKLQ 430

Human   475 AIKERI-GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISG 538
            |:...: .|.||      ....|:.|||.:.|:|.||:    :::.....|::||.:.|......
  Fly   431 AMTLEVNNYADD------NFTEEFAELNLQSDDYVENV----RYTSLLGAKQMREMLHKPAKPFE 485

Human   539 AAVVNAFYSSG---RNQIVFPAGILQPPF-FSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNK 599
            |....::..:.   .|.|..|..:|||.: :|....|::.:|.:..:||||:.|||||:||.|::
  Fly   486 AGSQLSYTPANILIENTIKVPVALLQPFYIWSDVYPNAIMFGTLASLIGHELIHGFDDSGRKFDE 550

Human   600 DGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQN 664
            .|:..|||.::|:|||.::..|...|||.:.:|   |..|.......||||||||:..||.||:.
  Fly   551 KGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYD---GIQLKESTAQSENIADNGGMRLAYTAYRK 612

Human   665 YIKK-----NGEEKL----LPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII 720
            :.:.     ||.:.:    ||.|....|||||::|||.||....|......:.||.|.||.||:|
  Fly   613 WYENQLTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWCNDAHPSVKALQVSTDQHMPGRFRVI 677

Human   721 GTLQNSAEFSEAFHCRKNSYMNPEKKC 747
            |:|.|..|||:.|:|...|.|||.:||
  Fly   678 GSLSNFEEFSKEFNCPAGSAMNPSEKC 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MME	NP_000893.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:341056	189/702 (27%)
Nepl21	NP_651646.2	M13	63..704	CDD:341056	187/702 (27%)