Protein Alignment MME and Nepl20

DIOPT Version :10

• Sequence 1: NP_000893.2
• Gene: MME / 4311
• HGNCID: 7154
• Length: 750
• Species: Homo sapiens
• Sequence 2: NP_651645.1
• Gene: Nepl20 / 43412
• FlyBaseID: FBgn0039613
• Length: 700
• Species: Drosophila melanogaster
• Alignment Length: 765
• Identity: 201/765 - (26%)
• Similarity: 344/765 - (44%)
• Gaps: 130/765 - (16%)

Human    31 LSVLVLLLTIIAVTMIALYATYDDGICKSSDCIK------SAARLIQNMDATTEPCTDFFKYACG 89
            ||||||..           .|.:|.:.:.:..:|      .||.:...|:...:||.||:.::||
  Fly    15 LSVLVLAA-----------PTSEDVLNQDTPYMKELMRQAKAAEIESFMNQKVDPCKDFYAFSCG 68

Human    90 GWLKRN-VIPETSSRYGNFDILRDELEVVLKDVLQEP-----KTEDIVAVQKAKALYRSCINESA 148
            .:.:.| .:.......|.|:.|...|...:..:|..|     ..|||    :.|..|.||:....
  Fly    69 NYKRINSALNMRVLTTGVFETLTKGLNRKILKMLNTPHDSHDTPEDI----QVKHFYESCLQIKE 129

Human   149 IDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAE-----KAIAQLNSKYGKKVLINLFVGTD 208
            ::|...|.|.:|:.:....|:..       |:||..:     ...|::..:||...:|.:.|.||
  Fly   130 LNSTYSEKLKRLIAEFGTMPLLE-------GSSWQEDDFDWLNTTARMAHRYGIMSIIGVGVATD 187

Human   209 DKNSVNHVIHIDQPRLGLPSRDYY--ECTGIYKEACTAYVDFMISVARLIRQEERLPIDENQLAL 271
            ..|:..::|:|:|....|.:|..|  ..|.||::.....:..::        |:.|.: :::||.
  Fly   188 FANNQKNIIYINQQEFPLKTRSMYMDNETAIYRQNYQNNIQLIL--------EKYLGV-KDELAR 243

Human   272 EMNKVM-ELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVN 335
            :..|.| |.|.::|:.........:...|...:|:|:::..::..::.....:::...:|
  Fly   244 KAAKEMFEFEVDLAHGLVDNNKHLNLRDLIELLTVAELRERYAPTLDTDQLIFVSMGEKI----- 303

Human   336 ISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNA---FRKA 397
                 .:.|..|...|...|..::.:.....:.|.:..|.|.:.:...|...::...|   |.|
  Fly   304 -----SDKVYEYNRRYQQNLVEVIERTPKSTVANYLFLRLIWEFIQKPSGVAEKPTEACVDFTK- 362

Human   398 LYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTL---DDLT 459
                           .|...|::|.:.|.|...    :|...::.:..|::..|.:||   ..|.
  Fly   363 ---------------TYFAKNLDNMIYRRYKNE----KSSREIDSMWHQLKSTFKETLLSSPALD 408

Human   460 WMDAETKKRAEEK--ALAIKERIGYPDDIVSNDNKLN--NEYLELNYKEDEYFENIIQNLKFSQS 520
            |::..|:..|..|  |:.::         |:|..|.|  .|:.:||.:..:..||:.| ::..|:
  Fly   409 WIEPSTRSLAIAKLEAMTLE---------VNNYVKENFTEEFADLNLQNTDCVENLRQ-VQMLQA 463

Human   521 KQLKKL----REKVDKDEWISGAAVVNAFYSSG----RNQIVFPAGILQPPF-FSAQQSNSLNYG 576
            ||:::|    .:.::..|.:|        |:..    .|.|..|..:|||.: :|....|::.:|
  Fly   464 KQMRQLYHQPAKPLEAGELLS--------YTPSNILLENSIKVPVALLQPFYIWSDVYPNAVMFG 520

Human   577 GIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNG 641
            .:..:||||:.|||||:||.|::.|:..|||.::|:|||.::..|...|||.:.:|   |..|..
  Fly   521 TLAYLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYD---GIQLKE 582

Human   642 INTLGENIADNGGLGQAYRAYQNYIKK-----NGEEKL----LPGLDLNHKQLFFLNFAQVWCGT 697
            .....||||||||:..||.||:.:.:.     ||.:.:    ||.|....|||||::|||.||..
  Fly   583 STAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWCND 647

Human   698 YRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKC 747
            ..|:.....:.||.|.||.||:||||.|..|||:.|:|...|.|||.:||
  Fly   648 VHPKVKALQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPIEKC 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MME	NP_000893.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:341056	189/711 (27%)
Nepl20	NP_651645.1	M13	56..697	CDD:341056	187/711 (26%)