Protein Alignment MME and Nepl17

DIOPT Version :10

• Sequence 1: NP_000893.2
• Gene: MME / 4311
• HGNCID: 7154
• Length: 750
• Species: Homo sapiens
• Sequence 2: NP_651641.1
• Gene: Nepl17 / 43408
• FlyBaseID: FBgn0039609
• Length: 681
• Species: Drosophila melanogaster
• Alignment Length: 760
• Identity: 188/760 - (24%)
• Similarity: 322/760 - (42%)
• Gaps: 133/760 - (17%)

Human    36 LLLTIIAVTMIALYATYDDGICKSSDC--------IKSAARLIQNMDATTEPCTDFFKYACGGWL 92
            |:...:||..:|:    ..|:.|....        |..:|.:...||.:..||.||:.||||.:.
  Fly    10 LIFVTLAVGSLAI----QGGVFKELTTPLGQQIMRIAKSAEMCSFMDTSVSPCDDFYGYACGNYA 70

Human    93 KRNVI---PETSSR---YGNFDILRDELEVVLKDVLQEPK-TEDIVAVQKAKALYRSCINESAID 150
            ..|..   .:|:.|   :.|:  ||.     ::.||.||: :.|.....:.|..|.||::.:|:.
  Fly    71 TINAATSQKDTNIRQLMFANY--LRR-----VRQVLNEPRISTDRPMEVRVKYFYESCLDTAALR 128

Human   151 SRGGEPLLKLLPDIYGWP-VATENWEQKYGASWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVN 214
            ::....||.:|.:..|.| |..::|:.   ..:.|.:.:|||..:|||..|:.::|..|..||..
  Fly   129 TKQRSHLLSVLREFGGMPAVEGKSWDY---VGFDAIEMMAQLLRRYGKLTLLGVYVVPDHFNSQI 190

Human   215 HVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMEL 279
            ..:.:.| ||.|...|  |...::|:           .|..:|....|.:.|........:::||
  Fly   191 KRLQLGQ-RLDLAESD--EFASLWKK-----------YALKMRLRNLLGLSEELARKTAEEIIEL 241

Human   280 EKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPF--SWLNFTNEIMSTVNISITNEE 342
            |.|::.:........||.|:.:...|:.:.:.:...:|...|  |||.      |..|:.:...
  Fly   242 ELELSRSAFDHRMNRDPRLMRHLTMLSNMSDAYGPILNVTRFVTSWLG------SEYNLPVFES- 299

Human   343 DVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETAT 407
                 .|.||.::|.||.......:.|.|        :|||...::.:.|..::.:.
  Fly   300 -----VPSYLFQVKKILLSTPNHVVANYM--------LSSLLTDFEITANEEQQKVI-------- 343

Human   408 WRRCANYVNGNMENAVGRLYVEAA------FAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETK 466
               |...:.....:.|..:...:.      .|.|.:.:..:|.:..||:.  :..|:.|::.:|:
  Fly   344 ---CHERITELFPDVVDHMVYHSLEQQNPYIANEMRSLWVELKSSFREML--SSPDIEWLEKQTR 403

Human   467 KRAEEK------------ALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQ 519
            :...||            |:..:|:.|  |.:||:               .:|:.| ||.|...:
  Fly   404 EELLEKLNGMSFEIAGGQAVNFEEQFG--DLVVSS---------------ADYYGN-IQRLLEVK 450

Human   520 SKQLKK--LREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPF-----FSAQQSNSLNYGG 577
            ::.|:.  |||  ....:..........|.:..|.:|.|...:|..:     :.|    :|.||.
  Fly   451 ARILRTDLLRE--SSSVYYYHGVTATPIYETETNLVVLPVSYMQHRYLWDDIYPA----ALKYGT 509

Human   578 IGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGI 642
            :|..:.||:.|||||..|.::..|:|.|.|:.|:...|:....|:..|   ||..|.|...|..:
  Fly   510 LGFTMAHEMAHGFDDLNRLYDSRGNLNDNWSTQTKVGFELVKNCLADQ---FSGMLYGNLRLRRL 571

Human   643 NTLGENIADNGGLGQAYRAYQNYIK--KNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVN 705
            .:..|:||||.|:..|..||..::.  :..|.:.||.:..:.:|||||:.||..|....||...|
  Fly   572 KSQAESIADNVGIRIAQSAYWKWLDQVEMEETESLPHMTQSPEQLFFLSAAQFMCSDIYPERRAN 636

Human   706 SIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750
            .::.:.|.|...|:...:.||..|:|||.|..:|.|||..||.::
  Fly   637 FVRNNFHPPYEARVFAMMINSPAFAEAFQCSNSSKMNPPNKCLMY 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MME	NP_000893.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:341056	177/705 (25%)
Nepl17	NP_651641.1	M13	55..678	CDD:341056	176/706 (25%)