Protein Alignment MME and Nep7

DIOPT Version :10

• Sequence 1: NP_000893.2
• Gene: MME / 4311
• HGNCID: 7154
• Length: 750
• Species: Homo sapiens
• Sequence 2: NP_651603.1
• Gene: Nep7 / 43356
• FlyBaseID: FBgn0039564
• Length: 717
• Species: Drosophila melanogaster
• Alignment Length: 813
• Identity: 199/813 - (24%)
• Similarity: 352/813 - (43%)
• Gaps: 194/813 - (23%)

Human    26 PLEISLSVLVLLLTII---------------AVTMIALYATYDDGICKSSDCIKSAARLIQN-MD 74
            ||...|:|.:|:..|:               |:|        |:    ::|.::|...:::: |:
  Fly    11 PLYTRLAVCILICVILNDCEARSIGDESHENAIT--------DE----TADYLRSHGAMMKSYMN 63

Human    75 ATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQEPKTEDIVA------- 132
            .:.:||.||:::|||.|  :||.....|.:...:||  ::...|.||.::..|...:|
  Fly    64 FSVDPCDDFYEFACGNW--KNVKTPRQSPHRRSNIL--DISYTLMDVTEQLLTRTKLAEALNVSA 124

Human   133 -VQKAKALYRSCINESAIDSRGGEP-LLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLN--- 192
             :..|:..|.||:..........:| .|.::..:.|:|....:       :|.| .:.:..|
  Fly   125 ELLVAQRFYNSCLAAELFPRPAADPAYLSVIRSLGGFPAVDRD-------AWNA-SSFSWFNMSA 181

Human   193 --SKYGKKVLINLFV---------------GTDDKNSVNHVIH-------------IDQPRLGLP 227
              |.||.:.||:..:               |.|      ||:|             :::.|:
  Fly   182 HLSNYGVRSLIHEEILPQHPFNPYFKLPELGFD------HVVHTAHVANTSSRAYQLNEHRM--- 237

Human   228 SRDYYECTGIYKEACTAYVDFMISV-ARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPE 291
             |.|.:...:.|:..:|.::.:.:. :..:..|::...|.::..| ::::.|:.:
  Fly   238 -RGYLKEYNLTKDEISAVIEGVFAFWSEALSIEDKFESDRDKCDL-LSEIEEVPR---------- 290

Human   292 DRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLK 356
                         ..|.::.:.:..||..|            .|.|...|     :...|..:|.
  Fly   291 -------------FGQWRSYYEIAWNGIDF------------YNGSSGGE-----FCDFYYVELD 325

Human   357 PILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMEN 421
            .:..|:: ..:.|.::.||:..:...|    ||.:....:.:           .|...|...:.|
  Fly   326 KVCAKHT-EAVANYLAMRFLYRMDDKL----KEPKQPEDQKV-----------NCLMIVQMTLPN 374

Human   422 AVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIG-YPDD 485
            ...|||:...|..|....:.|::.::|:...|.|:.:.|:||||:..|..|...|...|| |.::
  Fly   375 LFNRLYMAEHFTDEKHSEISDMVTEMRKAQRQILESVEWLDAETRAEALSKEAGITPVIGSYKNE 439

Human   486 IVSND--NKLNNEYLELNYKEDEYFENIIQNLKF--------------SQSKQLKKLREKVDKDE 534
            .:|:.  .::||    |...|..|.:::| ||:.              ...|..|.|...|...
  Fly   440 ELSDTLIREINN----LTIVEGSYAQSLI-NLRVLGTYLHRYAGLHADELPKDTKPLTLLVGMQ- 498

Human   535 WISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNK 599
                   |||||.:..|.:...||:|.||.:.....:||.:|.||.:||||:|||||..|.:|:.
  Fly   499 -------VNAFYYNLDNSVYVMAGVLHPPAYHRSWPDSLKFGTIGYLIGHELTHGFDTEGSSFDS 556

Human   600 DGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQN 664
            .|::.|||:::|.:.|:|::||.| .|.|........|.:.|..|..|||||.|||..|...|:|
  Fly   557 AGEVRDWWSRKSEAVFQERAQCYV-DYFNQYLIPEINQTIRGNETRDENIADAGGLRAALTGYRN 620

Human   665 YIKK------NGE-----EKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFR 718
            ::|:      :||     .:.:|||||:.:||||:.|||:||..|.||:....: |..|:...:|
  Fly   621 HMKQLQRSGADGETLAHKNEQMPGLDLSPEQLFFVGFAQLWCADYEPEHYWEEL-TGAHTVDKYR 684

Human   719 IIGTLQNSAEFSEAFHCRKNSYMNPE-KKCRVW 750
            ::|.:.|:.:|:|.:.|...|.|:|: :.||:|
  Fly   685 VLGAVSNNDDFAEVYKCPLGSPMHPKAESCRMW 717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MME	NP_000893.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:341056	184/740 (25%)
Nep7	NP_651603.1	M13	66..715	CDD:341056	184/742 (25%)