Protein Alignment MME and Nep5

DIOPT Version :10

• Sequence 1: NP_000893.2
• Gene: MME / 4311
• HGNCID: 7154
• Length: 750
• Species: Homo sapiens
• Sequence 2: NP_733186.2
• Gene: Nep5 / 43255
• FlyBaseID: FBgn0039478
• Length: 882
• Species: Drosophila melanogaster
• Alignment Length: 815
• Identity: 249/815 - (30%)
• Similarity: 395/815 - (48%)
• Gaps: 132/815 - (16%)

Human    31 LSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRN 95
            |..||::| :||:.:|:|.......||:|.:|:::||.||..||..|:||.||:::.||.|...:
  Fly   105 LLALVIIL-LIAIIVISLGLKKSSSICRSKECLRTAASLIYAMDEQTDPCEDFYQFTCGRWANEH 168

Human    96 VIPE--TSS---RYGNFDILRDELEVVLKDVLQ-EPKTEDIVAVQKAKALYRSCINESAIDSRGG 154
            ..|:  ||:   |.....|:|...|.:..::.: ||:     ||.|||.:||:|::...:|.|..
  Fly   169 PRPDSVTSNDWFRERQAHIMRVVREFLRSNITKSEPE-----AVGKAKTMYRACMDTKLLDKRDL 228

Human   155 EPLLKLLPDIYGWPV--ATENWEQKYGASWTAEKAIAQLNSKYG---------KKVLINLFVGTD 208
            |||:..|.. :|.||  :..|.....|:.:..|.|    |.||.         :.:.::|.:|.|
  Fly   229 EPLINYLLR-FGLPVLPSALNLTLGSGSKYATEAA----NVKYNWLQSIVSIKQHLTMDLIIGFD 288

Human   209 -----DKNSVNHVIHIDQPRLGLPSRD----------YYECTGIYKE------------------ 240
                 ...::|.:      .||.|..|          :.....|:::
  Fly   289 VFPDPFNRTINRI------ALGTPETDSAFPFNNDDSHKMLRKIHRKTIFMQNSDDEDDSEDDRE 347

Human   241 ------------ACTAYV--------DFMISVARLIRQEE-RLPIDE--NQLALEMNKVMELEKE 282
                        ..|||:        .:::.|...:.||| .|.|.|  .|......||.|.::|
  Fly   348 SEEEEAAKQTSTGMTAYLHYVRKVIEKYLLYVDPNVNQEEATLGITELVKQGVRVARKVHEFKEE 412

Human   283 IANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFS-WLNF----------TNEIMSTVNI 336
            ..|.| ||.......::|  :||..:||.....|..|... |:.:          ...|..|.|:
  Fly   413 AENMT-KPSKNPADDIVY--ITLQDLQNQTDKNIAPKTLPIWVRYMELILKGTRHAGNIQMTQNL 474

Human   337 S-ITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYG 400
            : ||::.|:.     ||..:...|....|..:::.:....|.:||...|.:.:...:.:.:...|
  Fly   475 TIITSQADIT-----YLQNIVEYLDDTPASHIESYLFLSTIEELVLHTSSSMRLLHSEYMRVAIG 534

Human   401 TTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAET 465
            |...|.....|||.||..:..||..:..:|.|..|....||.:::.||..|.:.:...:||||.|
  Fly   535 TEGSTPRSLYCANGVNSLLGMAVSYVLADADFTKEKLPKVERMLSDIRRSFDRLVKSTSWMDAAT 599

Human   466 KKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKV 530
            |::..:|:..:|..||:| ..:.|.:.||..|.........:.||:   :.|...:.:.||.| :
  Fly   600 KRKTIQKSAEMKSFIGFP-PWLRNASVLNAYYEGAEVNASTHLENL---MDFVHWQMMDKLNE-M 659

Human   531 DKDE---WISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDD 592
            ||.|   |.:..:.||||::...|.|..|..|||.||:.. ...:||||.||.::|||:||||||
  Fly   660 DKPEPIGWATSPSNVNAFHTFQSNAITVPIAILQYPFYDL-GLEALNYGSIGTILGHELTHGFDD 723

Human   593 NGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAG-GQHLNGINTLGENIADNGGLG 656
            :||.|::.|::|:||:.::...:..:::|.|.||..:  .||. .::::|..|||||||||||:.
  Fly   724 SGRRFDRAGNMVEWWSNRTIDEYVNRTECFVEQYSRY--HLADIDEYIDGELTLGENIADNGGMR 786

Human   657 QAYRAYQNYIKKNGEEK-LLPGLD-LNHKQLFFLNFAQVWCGTYRP---EYAVNSIKTDVHSPGN 716
            :|:.||:.|:|:.|.|: .||||: .:|:||||::|..:||.||.|   .||:    ||.|.||.
  Fly   787 EAFYAYRLYVKEVGRERSKLPGLEHYSHEQLFFISFGNLWCETYTPAASRYAL----TDSHCPGQ 847

Human   717 FRIIGTLQNSAEFSEAFHCRKNSYMNPEK-KCRVW 750
            .|:.|.|.||.||:..|.|.:.:.|||:: |||:|
  Fly   848 MRLRGVLSNSEEFARTFKCARGTPMNPDQPKCRIW 882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MME	NP_000893.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:341056	227/763 (30%)
Nep5	NP_733186.2	M13	151..880	CDD:341056	227/764 (30%)