Protein Alignment MME and Nepl16

DIOPT Version :10

• Sequence 1: NP_000893.2
• Gene: MME / 4311
• HGNCID: 7154
• Length: 750
• Species: Homo sapiens
• Sequence 2: NP_001097912.1
• Gene: Nepl16 / 43014
• FlyBaseID: FBgn0039277
• Length: 752
• Species: Drosophila melanogaster
• Alignment Length: 868
• Identity: 169/868 - (19%)
• Similarity: 288/868 - (33%)
• Gaps: 293/868 - (33%)

Human     1 MGKSE-----SQMDITDINTPKPKKK-QRWT---------------PLEISLSVLVLLLTIIAVT 44
            ||||:     ...:|.:.||...|.. ..|.               .:.|:.:.|::...::|..
  Fly    58 MGKSDEIEMIDSANIENFNTRYNKNSIIGWICCAPCIWLRTSAAVHKMAITSATLLVTTLLVASP 122

Human    45 MIALYAT---------YDDG-----------ICKSSDCIKSAARLIQNMDATTEPCTDFFKYACG 89
            ::.|.:|         |.||           .|....|...|:.:...::...:|||:|.|::|
  Fly   123 ILFLISTAPSPLPRDCYMDGDRCSPAVSAPPECSDPICEAVASSIQARLNWNKDPCTEFKKFSC- 186

Human    90 GWLK------RNVIPETSSR----------------YGNFDILRDELEVVLKDVLQEPKTEDIVA 132
             |..      .|:|...:|:                .|:|.||.:
  Fly   187 -WRNTPNKNITNLIEMGNSQKSVDSQMLYLFQNKIMNGSFGILHN-------------------- 230

Human   133 VQKAKALYRSCINESA--------IDSRGG------------EPLLKLLPDIYGWPVATENWEQK 177
                  |:.||:.::.        .||.||            .||:..:.|:...|:..
  Fly   231 ------LFESCLQQTTNSTVMHRIFDSLGGYLPVGSVGPSSIAPLIAKIYDLGPSPLVD------ 283

Human   178 YGASWTAEKAIAQLNSKYGKKVLINLFVGTDDKNS--VNHVIHIDQPRLGLPSRDYYECTGIYKE 240
                       ...:..||::..|.|.:.....:|  :...|....|: ..|||.......:..:
  Fly   284 -----------LYHDLSYGRRPHILLIISGPSTSSTILERKIRWMSPK-APPSRIRQGVPKLLAD 336

Human   241 ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRN--DPMLLYNKM 303
            ....::.:.:|.|              |...|.:.:.|..|::.....:...|.  |..:|||..
  Fly   337 LIENFLPYFVSYA--------------QRVSEKDTIFEFIKDLNKLQVEHSRRGFWDSTVLYNVS 387

Human   304 TLAQIQN--NFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARD 366
            :|..:..  |::|.|   |.:|                 ...:||...:||..|:..||||..|.
  Fly   388 SLQDLYPVLNWTLLI---PQNW-----------------SGPIVVRNSDYLKALEYFLTKYPTRV 432

Human   367 LQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAA 431
            ..|.:   .::..:..|.|.|.......|..::.....:::                  ||:
  Fly   433 AHNSL---LLLSALQILPRDYPSPEVCTRSTMWALPELSSS------------------LYI--- 473

Human   432 FAGESKHVVEDL--IAQIREVFIQTLDDLTWMDAETKKRAEEK--------ALAIKERI--GYPD 484
                ::|..|||  ..:..|:..::|      .|..|:....|        ||.|:.:.  |:
  Fly   474 ----AQHSSEDLKDTTKRAEIIFKSL------KAHLKRAPSLKGAALVKLSALKIQSQTWEGF-- 526

Human   485 DIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVD-------KDEWISGAAVV 542
               ||...|......||...:.:|:||::..|       |...|..|       .|.| :...|.
  Fly   527 ---SNTTDLLKSLQPLNITSECWFQNILEIYK-------KNKLEPNDISLNGGSHDAW-AYPIVS 580

Human   543 NAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWW 607
            ..||.:..:.||.|..::..|:|:|.....|:|..:|:.|..||.       |:..|..|
  Fly   581 TIFYDTLSHSIVVPLSVILIPYFNAVLPPYLHYASVGVSIAKEIL-------RSITKSFD----- 633

Human   608 TQQSASNFKEQSQCMVYQ---YGNFS-WDL---AGGQHLNGINTLGENIADNGGLGQAYRAYQNY 665
                    ::..:|:.:.   :.|:| .|:   :||..:                     :|.:.
  Fly   634 --------EKAMRCVPHSVNIFSNYSRMDILIHSGGMQI---------------------SYHSM 669

Human   666 IKKNGEEK---LLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTL-QNS 726
            :...|..|   .||||:|...|:|||..||..|.      ..|.:..|.::|....|:|.| ...
  Fly   670 LSLTGPIKGMARLPGLNLTPTQIFFLVSAQELCA------ESNYLGIDTNAPEFDNILGWLVAQG 728

Human   727 AEFSEAFHCRKNSYMNPEKKCRV 749
            ...:|.|.|...|.:|.:|.|.|
  Fly   729 GSATEVFKCPSGSMINVQKTCNV 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MME	NP_000893.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		7/23 (30%)
		Stop-transfer sequence. /evidence=ECO:0000255	16..23		1/7 (14%)
		M13	79..748	CDD:341056	147/746 (20%)
Nepl16	NP_001097912.1	GluZincin	176..750	CDD:472708	147/747 (20%)