Protein Alignment MME and Nepl15

DIOPT Version :10

• Sequence 1: NP_000893.2
• Gene: MME / 4311
• HGNCID: 7154
• Length: 750
• Species: Homo sapiens
• Sequence 2: NP_651098.2
• Gene: Nepl15 / 42701
• FlyBaseID: FBgn0039024
• Length: 686
• Species: Drosophila melanogaster
• Alignment Length: 757
• Identity: 190/757 - (25%)
• Similarity: 320/757 - (42%)
• Gaps: 107/757 - (14%)

Human    26 PLEISL-SVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNM-DATTEPCTDFFKYAC 88
            ||.:.| ::|..:..|.|.....|.|.|...|.:    :..||.:...| |...:.|.:|:.|||
  Fly     5 PLGLLLGAILFSICAIDASVPHPLAANYSIDILR----LAKAAHIKAYMGDEKEQACNNFYNYAC 65

Human    89 GGWLKRNVIPETSSRYGNFDILRDELEV-----VLKDVLQEPKTEDIVAVQKAKALYRSCINESA 148
            ..|.:.:...::.:|....:.|: ||.:     :||...:..:..   |.::.|..|.||..::.
  Fly    66 ANWPRLHPARKSKTRTNYLEELQ-ELYIRKSADMLKSATRGAENS---ADRQLKYFYGSCRLQTN 126

Human   149 IDSRGGEPLLKLLPDIY-GWP-VATENWEQKYGASWTAEKAIAQLNSKYGKKVLINLFVGTDDKN 211
             |:|.....|:.:.|.. ||| :...:|.| |...|.  :.:|.|..|.|..:.|.|.|..|.|.
  Fly   127 -DTRSALNTLQNVTDFRGGWPEIRVASWYQ-YEYDWL--QVVANLKRKLGVDIFIGLEVILDYKE 187

Human   212 SVNHVIHIDQPRLGLPSRDY----YECT-GIYKEACTAYVDFMISVARLIRQEERLPIDENQLAL 271
            ...|.:.|..|:..:..|.|    :|.| .||:.:.                       ||:|.|
  Fly   188 EKMHRLKIGAPQFPMSRRHYLHPHFEGTREIYERSI-----------------------ENKLKL 229

Human   272 EMNKVME-LEKEIANATAKPEDRNDPMLLYN-KMTLAQ-IQNNFSLEINGKPFSWLNFTNEIMST 333
            ...:..| ..:|:|:...:.|.:....|.:| .:|||| .:...:.|:.....|:::.|..:...
  Fly   230 YFPEQSEHWRQEVASQVVQIEQQLAKGLPHNPALTLAQTTRQRTAAEMKTAYGSYVDVTRYLQLI 294

Human   334 VNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKAL 398
            .|.::  ..|:.....:|::.|..::.:.....|.|...|:.:..|  .::|.....|
  Fly   295 FNDNL--YMDLYETPEDYMSNLVDVIRETPKLQLANYTMWKALEAL--DIARVPASQR------- 348

Human   399 YGTTSETATW--RRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVF---IQTLDDL 458
                  ...|  :....:....:|:...|.|.......|.:....|    |:.||   :|..:.|
  Fly   349 ------ADIWCVQLAQQFFPHQLESLFHRNYNHMQMINELQSTWSD----IKRVFREDLQASERL 403

Human   459 TWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQL 523
            .|:..||:::|..|..|:|......|     ||||..:...|....|.::.|::..|::...:.|
  Fly   404 LWLTLETRQKAITKLEALKLHFRTHD-----DNKLIRQMHGLILNMDRFYPNLVSVLQWKTQRGL 463

Human   524 KKL-REKVDKDEWISGAAVVNAF--YSSGRNQIVFPAGILQPPFF-SAQQSNSLNYGGIGMVIGH 584
            .|| .|.|.:||       |:..  |...:|:|..|...||..|| .....|.|.|..:|:::..
  Fly   464 AKLMTEPVAEDE-------VHKLPHYEIQKNRIQVPITFLQARFFWDPAYPNGLKYATLGVLLAR 521

Human   585 EITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENI 649
            ::.||||..||.::..|...:||...|.|::..::||...||..|.  ...|:.:...:.|...:
  Fly   522 QMLHGFDGVGRRYDAYGYKNNWWDHTSESSYSRRTQCFQEQYAIFV--EYKGKPVQDKDLLRRIV 584

Human   650 ADNGGLGQAYRAYQNYIKKNGE------EKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIK 708
            ||||.|..||||||.::|...|      .:.||.||.:|.|:|:|.:||::|..| ||    :::
  Fly   585 ADNGALDIAYRAYQQWLKNAAETPVIYQRERLPLLDHDHNQIFYLGYAQLYCTDY-PE----TVE 644

Human   709 TDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750
            .....|...|:...|.||.:|:.|:.|.:...:|...||.::
  Fly   645 RFDELPEQLRVNTALSNSQQFANAYGCSREEKLNARFKCTLY 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MME	NP_000893.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:341056	175/698 (25%)
Nepl15	NP_651098.2	M13	56..684	CDD:341056	175/698 (25%)