Protein Alignment MME and Nepl14

DIOPT Version :10

• Sequence 1: NP_000893.2
• Gene: MME / 4311
• HGNCID: 7154
• Length: 750
• Species: Homo sapiens
• Sequence 2: NP_651097.1
• Gene: Nepl14 / 42700
• FlyBaseID: FBgn0039023
• Length: 696
• Species: Drosophila melanogaster
• Alignment Length: 794
• Identity: 171/794 - (21%)
• Similarity: 324/794 - (40%)
• Gaps: 170/794 - (21%)

Human    24 WTPLEISLSVLVLLLTIIAVTMIALYATYD-----DGICKSSDCIK--SAARLIQNMDATTEPCT 81
            ||      :|.:.||.:..:...||.:..|     ..|.:|...::  .|..:..:::.:.:||.
  Fly     6 WT------TVFLWLLWLPHLQQNALVSGEDLPPPFQRIYQSEQTVRRSKAQDMGSHVNKSIDPCV 64

Human    82 DFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQEP-KTEDIVAVQKAKALYRSCIN 145
            ||:.||||.| |..:.|:..        |:.:.:..|..:::|. :.||.|.|::||.|::||::
  Fly    65 DFYAYACGNW-KSTLTPQQQ--------LQQQTDRELLLLVEEAVRREDSVIVRQAKELFKSCVS 120

Human   146 ESAIDSRGGEPLL-KLLPDIYGWPVATENWEQKYGASWTAE-------KAIAQLNSKYGKKVLIN 202
            ..|..|:..:..| :.:....|:|...       |:.|...       ..:..|..:||..:||.
  Fly   121 AQAHQSQQQQHFLSEFINQNGGFPAVP-------GSQWAVHHHDYNWLSVLGGLRLRYGMDILIG 178

Human   203 LFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACT---------AYVDFMISVARLIRQ 258
            |.||.:..|...:.:::.:|...:|:           |.||         .|......||..::.
  Fly   179 LRVGYNYGNVNENSLYLSEPSTLIPT-----------ELCTRNRSDIRDSIYEPLEHRVASELKS 232

Human   259 EERLPIDEN-QLALEMNKVMELEKEIA----NATAKPEDRNDPMLL--YNKMTLAQIQNNFSLEI 316
            ...|..||: :||.:   ::..|.|:.    ..:.:..|..:.:.|  |.:.||.:..|:..|::
  Fly   233 WLALGHDESARLAAD---ILSFEHELCGGMKGGSFESWDAEEQLYLANYTRKTLREFSNSIELDL 294

Human   317 NGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVS 381
            :.  :...:|..:|...|.::          ||||..:||..::.::...:.|.:.:|.:..|..
  Fly   295 DS--YVRASFGQDIYKPVYMA----------APEYFRQLKRTVSAHNISLVANYIMYRAVSALNF 347

Human   382 SLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQ 446
            .|     :.|...||            |.|.......:..|:|.||.......:.:..:::|...
  Fly   348 PL-----DDRPQLRK------------RECLERTKELLPTALGELYARQFGTEDGRIDLDNLYDT 395

Human   447 IREVFIQTLDDLTWMDAETKKRAEEKALAIKERI-GYPDDIVSNDNKLNNEYLELNYKEDEYFEN 510
            ::....|:| ...|:...|::..:||...:|.:: .|...::          |:|..:...|::|
  Fly   396 LKTALRQSL-GAEWLVEGTQRVGQEKLRNLKLQMPTYERPVI----------LKLQLERGNYWQN 449

Human   511 IIQNLKFSQSKQLKKLREKVDKDEWISGAA-VVNAFYSSGR-----NQIVFPAGILQPPFFSAQQ 569
            :.|.|...||::..:|.|     |::.... .|.|:.:..|     .::.....:||||.:..:.
  Fly   450 LRQLLGVVQSQRNNRLFE-----EFLPAPTDPVEAYEARVRLRPVQRRLDMGLALLQPPAYDPRY 509

Human   570 SNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDW---------WTQQSASNFKEQSQCMVYQ 625
            .:::.|..:|:.:..::...|||           ..|         |..|:|..:..:|.|...|
  Fly   510 GHAIRYATLGVQLAQQLVMAFDD-----------PHWSVGLLERDNWDGQTAWQYHIRSNCFARQ 563

Human   626 YGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYI---KKNGE-----EKLLPGLDLNH 682
            ..|:.        ...::...:.|.|:..:..|:|||..::   :.|.:     ::.||.|:.::
  Fly   564 VDNYL--------RPNVSATTQLITDSAAINVAFRAYLTWLGFQEPNNDFTKLTKETLPDLNYSN 620

Human   683 KQLFFLNFAQVWC-----------GTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCR 736
            ..||||.:||..|           ||  ||..:.|.:.: |:.....:.|.|:||.||:..|.|.
  Fly   621 TALFFLAYAQEHCSLEEARPRDEQGT--PEGYLYSARQN-HTWTRLLVNGPLRNSVEFASEFRCP 682

Human   737 KNSYMNPEKKCRVW 750
            ..|.|||..||.::
  Fly   683 IGSPMNPASKCIIY 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MME	NP_000893.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:341056	159/728 (22%)
Nepl14	NP_651097.1	M13	60..693	CDD:341056	158/729 (22%)