Protein Alignment MME and Nepl13

DIOPT Version :10

• Sequence 1: NP_000893.2
• Gene: MME / 4311
• HGNCID: 7154
• Length: 750
• Species: Homo sapiens
• Sequence 2: NP_651096.1
• Gene: Nepl13 / 42699
• FlyBaseID: FBgn0039022
• Length: 741
• Species: Drosophila melanogaster
• Alignment Length: 763
• Identity: 181/763 - (23%)
• Similarity: 304/763 - (39%)
• Gaps: 152/763 - (19%)

Human    64 KSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDEL-------EVVLKDV 121
            |.|..:.:.|:.:.:||||||:||||.|          .||....:..|||       |..:.:.
  Fly    55 KIATDVQKYMNLSADPCTDFFEYACGQW----------GRYHKRQLRPDELSTAQQLMETKISEQ 109

Human   122 LQEPKTE--------------DIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGW-PVAT 171
            ||:..|:              .:..|:|.:|.|.||:...|..|.....|:|:|.|..|. .|..
  Fly   110 LQQLLTQPLPPQHHPNGYSGASMTNVRKVRAFYESCVAVEANASERRRFLMKILKDNGGLRNVPN 174

Human   172 ENWEQKYGASWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTG 236
            .||:  :...|.  :.:.:|...||..:|:.|.:..:.:....:.|:..:|:|          |.
  Fly   175 SNWQ--HNRQWV--QTLGELRRNYGLDILLGLEIDLNLQTMKGNTIYFGEPKL----------TI 225

Human   237 IYKEACTAY----VDFMISVARLIRQE--ERL----PIDENQLALEMNKVMELEKEIANATA--- 288
            |..|.|.|.    ......|..|::|:  |.|    .:|..:.|.....::..|.|:.....
  Fly   226 IPAEHCNALATRGAQVRDEVYELVQQQVTENLRDWFGMDTGEAARFAGDIIRFEFELCKQMGEQD 290

Human   289 --KPEDRNDPML---LYNK---------------MTLAQIQNNFSLEINGKPFSWLNFTNEIMST 333
              |||:...|.:   :|..               |||.::.:...   |...|..|
  Fly   291 IQKPEEEFPPAIQAQIYGARSRTGQERLRRQKGGMTLTELTSEMG---NHLDFKML--------- 343

Human   334 VNISITNEEDVVVY--APEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRK 396
            |.:.:.::....||  :|||   :|.::....|.:...:..:...:.| :.|::..:|:
  Fly   344 VEVILESQYPSQVYLRSPEY---VKHVVRTVKANNRITVGGYILYVAL-NELNQPPEEA------ 398

Human   397 ALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKH----VVEDLIAQIREVFIQTLDD 457
                 .|:.|  |:|...........:|.::........:||    |..|:|..:.|.|     .
  Fly   399 -----PSQRA--RQCVQVTQRLFPQVLGEMFQRHVQRDNAKHDLDAVFNDVIKALEEQF-----H 451

Human   458 LTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELN----YKEDEYFENIIQNLKFS 518
            :.||| |..:||....|: :.|:..||          .:.|:|.    .|.::|:..:...||:.
  Fly   452 VEWMD-ENDRRAARTRLS-QYRVSLPD----------YQSLDLTDLQFQKSEDYWRRLEIALKYR 504

Human   519 QSKQLKKLREKVDKDEWISG--AAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMV 581
            ..:|.:.||.. |..:...|  |..|.|..|..:..::...|:||.|:::.....||.|..:|..
  Fly   505 SHQQFEALRGN-DFGQDADGLDAFEVRAALSPRQQMVLVGWGLLQAPYYNYYYPKSLKYALLGHR 568

Human   582 IGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLG 646
            :...:...|||.|  :|........|.:.:.|.::..|:|...||.::.::..|  .......|.
  Fly   569 LASALVQAFDDEG--WNNHPQATAQWNEVTMSGYRNASECQRAQYSSYLYNEPG--EFRNATRLR 629

Human   647 ENIADNGGLGQAYRAYQNYIKKNGEEKLLP--------GLDLNHKQLFFLNFAQVWCGTYRPEYA 703
            |.|||..||..|:.||..::::. :.||.|        .|:..:.||||:.|||..|.....:.|
  Fly   630 EIIADGSGLNLAFNAYLAWLEQQ-DHKLRPLLAKETLSELNFTNTQLFFIYFAQTRCWAKDNQDA 693

Human   704 V-NSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750
            : :|:....|:|..:.:.|.|.|||||...|.|...:.||...||.|:
  Fly   694 ILDSMPLMQHTPERWDVNGPLSNSAEFGREFGCALGTPMNSGDKCLVY 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MME	NP_000893.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:341056	176/744 (24%)
Nepl13	NP_651096.1	M13	68..738	CDD:341056	175/745 (23%)