Protein Alignment MME and Nepl12

DIOPT Version :10

• Sequence 1: NP_000893.2
• Gene: MME / 4311
• HGNCID: 7154
• Length: 750
• Species: Homo sapiens
• Sequence 2: NP_649924.1
• Gene: Nepl12 / 41172
• FlyBaseID: FBgn0037727
• Length: 702
• Species: Drosophila melanogaster
• Alignment Length: 797
• Identity: 191/797 - (23%)
• Similarity: 327/797 - (41%)
• Gaps: 175/797 - (21%)

Human    29 ISLSVLVLLLTIIAVTMI-----ALYATYDDGICKSSDCIKSAAR---------LIQNMDATTEP 79
            :.|..|:||..|:|..:.     :|....::.....|...:|||.         :...|:.:.||
  Fly     6 LKLISLMLLWVIVAAVLTDCEARSLVDRSENSDSNGSSTNRSAAEYQLQEYAEFMKSYMNQSVEP 70

Human    80 CTDFFKYACGGWLKRNVIPE---TSSRYGNFDI---LRDELEVVL--KDVLQEPKTEDIVAVQKA 136
            |.:|::||||.:  |||.|:   ..||....|:   |.|..|.:|  .|:.:.......:||  |
  Fly    71 CENFYEYACGNY--RNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSELAV--A 131

Human   137 KALYRSCINESAIDSRGGEP-LLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKKVL 200
            :..|.:|:..:.......:| .|.|:..|.|:|...       |.:|.|
  Fly   132 QRFYNACLGANLHPFNAADPAYLSLIRSIGGFPAVD-------GDAWKA---------------- 173

Human   201 INLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLP-- 263
                   .:.|.:|...|:..          |...|:.:|.......|        ....:||
  Fly   174 -------SNFNWINMSAHLAN----------YGANGLIRETLQLRYPF--------EPYTKLPEL 213

Human   264 ------IDENQLALEMNKVMELEKE----IANATAKPEDR------------------------N 294
                  :.|..::....:...|.:|    ...|...||||                        .
  Fly   214 GFDHIIVHEENISRNTTRAFRLNEERMHGYLRAFGLPEDRIREAIAGVFAFWRDALEIPPQCEVF 278

Human   295 DPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPIL 359
            ||..:......::...|.|       :|.|:.||::                :...|..:|..:.
  Fly   279 DPYRIKRVFPQSEYYYNIS-------WSGLHSTNKL----------------FCDFYYVELDKVC 320

Human   360 TKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVG 424
            .:: .:.:.|.::.:.:......| :..:..||.....||                 .:|.....
  Fly   321 ARH-RKAVANYLAMKLLYRFDPKL-KAPRYQRNYCSVTLY-----------------QSMRFLFN 366

Human   425 RLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIG-YPDDIVS 488
            :||:...|:...:..:.:::.::|:...:.|:|..|:|||::.||..|...|:.||| :.||.:|
  Fly   367 KLYMANNFSEAKRLEMSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDALS 431

Human   489 NDNKLNNEYLELNYKEDEYFEN-------IIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFY 546
              :::..|...|...||.|.|.       ::|..:|| |:..::|.......:.::|..|...:|
  Fly   432 --DRIIREINSLKVIEDRYAETNINLQHLVVQINRFS-SRHFQELTNDTKPQKILTGLQVGAGYY 493

Human   547 SSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQS 611
            :.. |.|...||:::||.:......||.:|.:|.::|||:.||||.....|:.:|.:....::.|
  Fly   494 TPD-NSINVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEIS 557

Human   612 ASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAY----QNYIKKNGEE 672
            ....:::::|.:..||.:..... .:.:||..||.||||||.||.||..||    |..::..|:|
  Fly   558 QQALEDRAECYMDYYGKYQVPEI-SRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQE 621

Human   673 KL---LPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFH 734
            ::   :|||||..:|||||.|||::|..|..|:....: :|||:...||::|.|.||.:|..|::
  Fly   622 RISDAMPGLDLTPEQLFFLGFAQLFCSHYEEEHYWKGL-SDVHTFDQFRVLGVLSNSEDFFHAYN 685

Human   735 CRKNSYMNP-EKKCRVW 750
            |...|.|.| .|.||:|
  Fly   686 CSVGSGMRPGAKTCRLW 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MME	NP_000893.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:341056	175/729 (24%)
Nepl12	NP_649924.1	M13	68..700	CDD:341056	176/731 (24%)