Protein Alignment MME and Nep2

DIOPT Version :10

• Sequence 1: NP_000893.2
• Gene: MME / 4311
• HGNCID: 7154
• Length: 750
• Species: Homo sapiens
• Sequence 2: NP_001246914.1
• Gene: Nep2 / 40588
• FlyBaseID: FBgn0027570
• Length: 774
• Species: Drosophila melanogaster
• Alignment Length: 717
• Identity: 255/717 - (35%)
• Similarity: 402/717 - (56%)
• Gaps: 40/717 - (5%)

Human    53 DDG-ICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEV 116
            |.| :|.:.:||.:|:.:::.|....|||.:|:::|||.:|:...||:.......|.::.|:|:.
  Fly    79 DSGDVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQE 143

Human   117 VLKDVL--QEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWP-VATENWEQKY 178
            .|||::  :.|:||. ...:....||::|:|::.|::.|.||:.::...:.||| :..::|..
  Fly   144 QLKDIITAERPETEP-KHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIKGDSWNA-- 205

Human   179 GASWTAEKAIAQLNSK-YGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEAC 242
            ..|||.::.:.:..:. :....:|:..:|.|.:||...:|.:||..|.| ||:|. ..|..:...
  Fly   206 DDSWTWQEQVKKFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLDQSSLAL-SREYL-VKGFNETLV 268

Human   243 TAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQ 307
            |||..:|:.:|.|......|...|..|:|      |.|..:||.:...|.|.:...|||..|.||
  Fly   269 TAYYKYMVDIAVLFGANRDLAKTELLLSL------EFEMALANISWPNEKRRNSSELYNLRTPAQ 327

Human   308 IQNNFSLEINGKPF-SWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLM 371
            :|..:       |: .|:::.|.::.. .:::..:|.:.:..|.:...|..:|.|...|.:.|.|
  Fly   328 LQAAY-------PYVQWVDYMNALLPE-GLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANYM 384

Human   372 SWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMEN-----------AVGR 425
            .||.....|..||..:::.:..:..||.|...:.|.|:.|.:....:|:.           :||.
  Fly   385 FWRIHGFSVGFLSEEFRKRQLQYATALSGRQEQEARWKECVDIATSSMDEVCEDDFDSLGISVGS 449

Human   426 LYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSND 490
            |||...|..:||....:::.:||.||...||::.||||:|||.|:.|..::...|||||:::.|:
  Fly   450 LYVGKHFHKDSKANALEMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNE 514

Human   491 NKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGA--AVVNAFYSSGRNQI 553
             ||...|.:|:...|:|||:.:....|.......|||..|:|.:|:..|  |:|||||||..|.|
  Fly   515 -KLAAYYAKLDIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYSSLENSI 578

Human   554 VFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQ 618
            .|||||||..||:||:...:|:|.||.||||||||||||.||.|:..|:|.|||...:...:..:
  Fly   579 QFPAGILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAK 643

Human   619 SQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPGLDLNHK 683
            ::|::.||||:: :.|.|.:||||||.|||||||||:.::|.||:.:.:|:|.|..|||||...:
  Fly   644 AKCIIEQYGNYT-ERATGLNLNGINTQGENIADNGGVKESYIAYRRWAEKHGPEAKLPGLDYTPE 707

Human   684 QLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCR 748
            |:|::...|.||..||.|.....|.|.||||..||::|:|.|..:|::.|||.:.|.|||.:||.
  Fly   708 QMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCE 772

Human   749 VW 750
            ||
  Fly   773 VW 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MME	NP_000893.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:341056	244/686 (36%)
Nep2	NP_001246914.1	M13	104..772	CDD:341056	245/688 (36%)