Protein Alignment MME and Nepl10

DIOPT Version :10

• Sequence 1: NP_000893.2
• Gene: MME / 4311
• HGNCID: 7154
• Length: 750
• Species: Homo sapiens
• Sequence 2: NP_610787.1
• Gene: Nepl10 / 36366
• FlyBaseID: FBgn0033742
• Length: 633
• Species: Drosophila melanogaster
• Alignment Length: 768
• Identity: 162/768 - (21%)
• Similarity: 292/768 - (38%)
• Gaps: 197/768 - (25%)

Human    31 LSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRN 95
            :..|:||.:.:....|.:.|..|..:..|:|       :..|::.||.|||:|:.:|||.:
  Fly     1 MGCLLLLCSCLVALFIPIQAIVDINVATSND-------IHNNLNRTTSPCTNFWNFACGRF---- 54

Human    96 VIPETSSRY-GNFDILRDELEVVLKDVLQEPKTE-DIVA---VQKAKALYRSCINESAIDSRGGE 155
               .::|:| .||:.:.|:....:.:.::....| |.:|   :::.:..|::|..    |:|
  Fly    55 ---SSASKYVDNFERVEDQFATAMVEFMESHLGENDTLAPRLIKQMRQYYKACKE----DTR--- 109

Human   156 PLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSK----YG-KKVLINLFVGTDDKNSVNH 215
                   .::|.|...|...|     |.       |:.|    || ..|.|:..|.....:|:..
  Fly   110 -------KLHGNPRPEELVNQ-----WI-------LHPKKFLVYGLNGVFIDERVDVAANDSMRW 155

Human   216 VIHIDQPRLGLPSRDY-----YECTGIYKEACTAYVDFMISVARLIRQEERLPIDENQLALEMNK 275
            ||.:..|.   |:..|     .:...:|:||.     :.:.|.:|:.:..:|   :::...|...
  Fly   156 VIQLRMPD---PADRYSDRRVLQLMRLYEEAW-----YSMGVVKLVEKMHQL---QDKYRAEYPV 209

Human   276 V-----MELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIMS-TV 334
            |     .||.:||                       .|.::|.:|:.|     :|.|.|:.. |.
  Fly   210 VYTWSFSELRQEI-----------------------PIPHSFFIELLG-----VNHTEELYHLTF 246

Human   335 NISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALY 399
            .:|     ||     |||.:                 .:|.:.|..|....||..:|.      |
  Fly   247 EVS-----DV-----EYLRE-----------------CFRCLRDFASEPKDTYIRARQ------Y 278

Human   400 GTTSETATWRR----CANYVNGNMENAVGRLYVEAAFAG--ESKHVVEDLIAQIREVFIQTLD-- 456
            ....|:....|    |.:::...:...:..:|....:..  |....|.::::.::..|.|.||
  Fly   279 VLVEESEPRERNPRSCIHHMRAYLPLGMNYIYDRFIYQNREEDTSKVLEILSTLKAAFGQYLDAN 343

Human   457 -------DLTWMDAETKKRAEEKALAIKERIG-YPDDIVSNDNKLNNEYLELNYKEDEYFENIIQ 513
                   .|.::      ||:.:.:.||  || .|::  .:....||.|...|:....:..|:::
  Fly   344 RLQLTPNQLAYV------RAKLEGIQIK--IGNLPEE--KSPEFYNNHYGSANFSATNFLANLLE 398

Human   514 NLKFS---QSKQLKKLREKVDKDEWISGAAVVNA----FYSSGRNQIVFPAGILQPPFFSAQQSN 571
            .....   |:..|.....:||...:.....|..|    ||.:.||.|..|...||.|.|..::..
  Fly   399 AFALRTRLQNAGLLARNSRVDLRHYYVNDNVRKARTSPFYENERNTITVPMEFLQWPLFDHREHT 463

Human   572 SLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQ-QSASNFKEQSQCMVYQYGNFSWDLAG 635
            ...:..:|.|:|||:.|.|:..|..|:..|:......: :.:..|::..:|...|
  Fly   464 IFQHSLLGAVLGHEMNHAFEQEGILFDAAGNESPVGLEIRESKPFRDAIKCAEEQ---------- 518

Human   636 GQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLP---GLDLNHKQLFFLNFAQVWCGT 697
                 ...:|.|.:||..||..||.|:......:.:.:..|   ..:....|||.|::||.:||:
  Fly   519 -----PFVSLKERLADLNGLQLAYDAFFGLAHDSRQFEYRPYAFEQEFTAPQLFHLSYAQFFCGS 578

Human   698 YRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750
            ..|..|        |...:.|:..::.|..:|:..|:|.    .:|...|.:|
  Fly   579 LPPVIA--------HDRDDERVNVSVGNLRQFAYDFNCE----TSPSSVCEMW 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MME	NP_000893.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:341056	149/716 (21%)
Nepl10	NP_610787.1	GluZincin	41..608	CDD:472708	147/704 (21%)