Protein Alignment MME and Nepl9

DIOPT Version :10

• Sequence 1: NP_000893.2
• Gene: MME / 4311
• HGNCID: 7154
• Length: 750
• Species: Homo sapiens
• Sequence 2: NP_609815.1
• Gene: Nepl9 / 35020
• FlyBaseID: FBgn0032613
• Length: 652
• Species: Drosophila melanogaster
• Alignment Length: 737
• Identity: 138/737 - (18%)
• Similarity: 251/737 - (34%)
• Gaps: 199/737 - (27%)

Human    68 RLIQNMDATTEPCTDFFKYACGG-----------------WLKRNVIPETSSRYGNFDILRDELE 115
            :|::..:.:.:||.||:.:|||.                 :.|::.:...::..|||:.:...|.
  Fly    52 QLVKIKNDSMDPCDDFYAHACGNFDQTKEENSDDFLPPYLYNKQDRMNFFTAEVGNFETIPGRLI 116

Human   116 VVLKDVLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQK--Y 178
            ..|....::.:..::....:..:.:...::|....:|..|.|       ..||.....||::  |
  Fly   117 SQLYTECRKREERNVFTPTRLTSHWERMLDEIPFLARHKEVL-------SSWPFLKHQWERRRLY 174

Human   179 G-ASWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEAC 242
            | .:|..  ..||| :.:|...|::::...|       .|:: .|...||              |
  Fly   175 GQLNWIV--LSAQL-AAHGLPTLLHIYFALD-------TIYV-SPMEELP--------------C 214

Human   243 TAYVDFMIS-----------VARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDP 296
            .:..||..|           |:|:|..|.|:...|  :..|:..|..|.:.....|::|   .:.
  Fly   215 PSIADFQSSLSDVLEGRHHQVSRIISHEMRVLCRE--MRGELPLVRSLSQNTRTNTSRP---GEE 274

Human   297 MLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNE-IMSTVNISITNEEDVVVYAPEYLTKLKPILT 360
            .||.::.|:...|..|:.         |||:.| ::......:    ||     |.:|:...:|.
  Fly   275 QLLLDENTMDYFQQYFAA---------LNFSEERLVGARKFPL----DV-----EKITQAWEVLR 321

Human   361 KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGR 425
            ....|.:.|.:.|:....|  .....|:.|.. |.:.|:....:....||              .
  Fly   322 HTETRIVYNYVMWQAREQL--RYPDCYRVSEE-FERLLHAEYWQWHVLRR--------------H 369

Human   426 LYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSND 490
            |..|.|.|....|...  ..::|...:...|   |.........|:|.|.:...:....:...|.
  Fly   370 LSREVALASYQLHTTR--FQKLRRSKLSRRD---WYGHLWPASVEKKELQVARILQNHAENYLNI 429

Human   491 NKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKK--LREKVDKDEWISGAAVVNAFYSSGRNQI 553
            .:||..|..|..:::.::.|::    ..:..||:.  :...||:::       ||
  Fly   430 TELNENYEGLKLEKNSFYANLL----ILRRAQLRHSFVSPYVDEED-------VN---------- 473

Human   554 VFPAGILQPPFF----------SAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWT 608
                   ||.:|          |..:.....|...|:.:..|.....|.:|..     ..:|...
  Fly   474 -------QPAYFLRHFLHFVLLSLHRPTYHYYATHGLELWRESRLLLDTDGHY-----TAMDCLE 526

Human   609 QQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKN---- 669
            :||..:: :.....:|:        ..|.|         .||:   :.|.||::|..:...
  Fly   527 RQSFQHY-DAKLAPIYR--------PLGSH---------EIAE---IFQFYRSFQYSLTDYHFWL 570

Human   670 -------GEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSA 727
                   .|..:|....||..::.|...||..|......:|....:..::.|
  Fly   571 QGERFAFAETFVLDYFGLNPHRVLFYAVAQQLCNRQTEIFAAQLNRGYMNLP------------- 622

Human   728 EFSEAFHCRKNSYMNPEKKCRV 749
            ||.|||.|.....|||..:|.:
  Fly   623 EFQEAFKCGAEKAMNPPSRCMI 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MME	NP_000893.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:341056	136/723 (19%)
Nepl9	NP_609815.1	GluZincin	62..642	CDD:472708	136/723 (19%)