Protein Alignment MME and Nepl8

DIOPT Version :10

• Sequence 1: NP_000893.2
• Gene: MME / 4311
• HGNCID: 7154
• Length: 750
• Species: Homo sapiens
• Sequence 2: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Alignment Length: 767
• Identity: 180/767 - (23%)
• Similarity: 299/767 - (38%)
• Gaps: 207/767 - (26%)

Human    40 IIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRY 104
            ||.:.::.|.|        :|...:....::.::|....||.:::.:|||.:..|: |.:|.
  Fly     3 IICLLLVPLVA--------ASSNTRLLNGILSHVDKEANPCENYYNHACGQYNMRH-IDDTF--- 55

Human   105 GNFDI--------------LRDELEV--VLKDVLQEPKTEDIVAVQ-KAKALYRSCINESA-IDS 151
              |||              |.||||:  .|.|.       ::.:|. |....|.||..... :||
  Fly    56 --FDIIQMLDHQVNQNLVKLMDELEMSSQLPDF-------NVSSVDGKVLRYYLSCRGAPRNMDS 111

Human   152 RG--------GEPLL--KLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYG-KKVLINLFV 205
            ..        ||.|.  :.:||...||  .||::      |.  ||:|.|: :|| ..|..||.|
  Fly   112 LSQYLKVISPGEGLTWPQFIPDGSSWP--QENFK------WL--KALAHLH-RYGLTNVFFNLEV 165

Human   206 GTDDKNSVNHVIHIDQPRLG----LPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLPIDE 266
            .::.:|:..:::.::.|..|    ||:               :::: ::||..:|    ::|..|
  Fly   166 VSNPRNASEYMVELNTPTFGEESQLPN---------------SFIE-ILSVLYII----KVPSSE 210

Human   267 -NQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEI 330
             ..||.:|..:..|.|.:.|    |.|     .|.|:....:   :|.:|..   .:|..|. ||
  Fly   211 IITLARKMRTLELLLKTMIN----PID-----TLNNRYISIR---DFQMETG---HNWQRFF-EI 259

Human   331 MSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFR 395
            :  :..|...|..|:|....|.|.||.::.|..||.:.:.:..||.:.|:.
  Fly   260 L--IGSSAAPELQVLVRNFRYFTALKELMDKQDARLVASYIMTRFAIFLLD-------------- 308

Human   396 KALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGE--SKHVVE--DLIAQIREVFIQTLD 456
            :.:.|..|     ..|.:.|..||..|...||.|..|...  |.:::|  |:..::|..|:..:|
  Fly   309 ETMGGRES-----TECVSQVRRNMNLAANMLYKERFFEDSTFSANILEIKDIFEKLRHQFLLQVD 368

Human   457 ----DLTWMDAETKKRAEEKALAIK-ERIGYP--DDIVSNDNKLNNEYLELNYK--EDEYFENII 512
                :||   |...|....||.||: ..:..|  ||:   .:.:...|.:|.:.  |.:|.:..:
  Fly   369 QNHLELT---ALQMKFFVRKAEAIEINVVNLPKTDDL---RHFIGQYYQDLQFPTGELDYHQEHL 427

Human   513 QNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVF--PAGILQP--PFFSAQQSNSL 573
            :.|:|...|.|                |..:..:|..:|.:.:  .|..|.|  |||..:..:..
  Fly   428 KVLQFRTQKML----------------AQSSKGHSEEQNILTYRSQAAPLPPPQPFFQLESEDVF 476

Human   574 NYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQS--ASNFKEQSQCMVYQYGNFSWDLAGG 636
            .|..:|.::.|.:...|...|.....||:      .||  :..|:|...|:.....|
  Fly   477 KYSLMGYIMAHHLISAFATEGITIGSDGN------DQSFRSHRFEEAVSCLSRNSEN-------- 527

Human   637 QHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPGLDLNH---KQLFFLNFAQVWCGTY 698
                    :.|::.|..||..||..|....|....      ||..|   :|:||||..|.:||
  Fly   528 --------IDESMGDIAGLELAYFTYAKMAKNRNR------LDFTHLPPEQIFFLNVGQFFCG-- 576

Human   699 RPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPE-KKCRV 749
                  ||.....:.....|:...::....|.:||.|.:|   .|: :|||:
  Fly   577 ------NSDMLVQYKEDQVRLQRAIEGFEPFDKAFGCYRN---KPKHEKCRL 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MME	NP_000893.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:341056	172/725 (24%)
Nepl8	NP_609795.2	GluZincin	32..618	CDD:472708	172/727 (24%)