Protein Alignment MME and Nepl7

DIOPT Version :10

• Sequence 1: NP_000893.2
• Gene: MME / 4311
• HGNCID: 7154
• Length: 750
• Species: Homo sapiens
• Sequence 2: NP_609577.2
• Gene: Nepl7 / 34671
• FlyBaseID: FBgn0032442
• Length: 669
• Species: Drosophila melanogaster
• Alignment Length: 758
• Identity: 201/758 - (26%)
• Similarity: 321/758 - (42%)
• Gaps: 130/758 - (17%)

Human    33 VLVLLLTIIAVTMIALYATYD-----DGICKSSDCIKSAAR-LIQNMDATTEPCTDFFKYACGGW 91
            |..|..|:|::|:|......|     .......:.::...| |:..|:.|.:||.:|::::||||
  Fly     2 VNALWATLISLTLIGRVLANDLFSLPPATNHREEMLEDYGRFLLSTMNRTIDPCENFYEFSCGGW 66

Human    92 LKRNVIPETSSRYGNFDILRDELEVVLKDVLQ---EPKTEDI------VAVQKAKALYRSCINES 147
            .|.:::||.:......:.::.:::..::..||   :.:.||:      .|..|||..|.||:...
  Fly    67 KKADLVPEQARNTSFLNAIQHKIDEQIQGFLQNATKRELEDLGVNGTTSAEIKAKQFYASCVEMK 131

Human   148 AIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKKVLINLFVGTDDKNS 212
            |..|.|.:..::...|......||.:|            ......|||....|:.|.|.....:.
  Fly   132 ANLSLGYQYFMEHDGDRLKERNATYDW------------MYINFMSKYDIYPLLALKVHYSTSSR 184

Human   213 VNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLPIDEN-----QLALE 272
            ...::      |.|||:   ...|..:|             :|........:|.:     |....
  Fly   185 KFDIL------LTLPSK---VLAGFSEE-------------QLKNMTREFGLDSSAEKVKQFVEN 227

Human   273 MNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNN-------FSLEINGKPFSWLNFTNEI 330
            .|.:.:.|:   |..:..:.||:...|..|..|.:.:::       |.|..||...|.....|:
  Fly   228 FNNLTQFER---NLVSLAKSRNETEQLNFKEFLVKHKHDRLNWTRFFELAFNGSQESHWPVLNQ- 288

Human   331 MSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMS-WRF------IMDLVSSLSRTYK 388
                   :.|..|:|.:..:  |.|:.:......|:|..... |:.      :.....|||.||
  Fly   289 -------LDNINDLVFFLEQ--TNLETLKGYIKMRELVKFYGLWKTQTKTGGVQSECRSLSETY- 343

Human   389 ESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQ 453
                 |..||       ..|                  ::...|..|.:..:..:...|::.|..
  Fly   344 -----FNYAL-------LPW------------------FIGKVFDKERRADILSVAKDIKDTFYD 378

Human   454 TLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFS 518
            .||..||:|.:|:.:|:.|..::...:||.||:      .:.|.::..|.:.....|..:||...
  Fly   379 LLDHHTWLDEDTRSQAKTKLASMDILVGYTDDL------QHREVIDGVYSDINMTGNWFENLCIL 437

Human   519 QSKQLKKLREKVDKD--EWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMV 581
            :..:.:.....|||.  ..:.....|||:|:...|......|:.|.||:.....:.|.|.|:|.:
  Fly   438 EGSRARIRLRSVDKALIPLLMPTRTVNAYYADFLNLAFITIGMAQWPFYHIDFPDVLKYAGVGNI 502

Human   582 IGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLG 646
            ||||:.||||.....:|.||...:||:..|..||||:.:|:..||..|   :..|...||..|.|
  Fly   503 IGHEMAHGFDSYCYQYNYDGKKTNWWSSASLRNFKERYRCLESQYNKF---ILMGVQTNGSLTSG 564

Human   647 ENIADNGGLGQAYRAYQNYIKKNGE----EKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSI 707
            :|||||.|...||.|::   :|.|:    ||.|.|::.|:|||||:.|||.||........:..:
  Fly   565 DNIADNVGTRMAYYAFK---RKTGDKAWLEKPLRGVNFNNKQLFFVKFAQTWCNGKDNGDKLRRL 626

Human   708 KTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750
            |||||:...||:.|||.|..||||||:|:..:.|||.|||.||
  Fly   627 KTDVHAYDEFRVQGTLSNMPEFSEAFNCKLGTEMNPLKKCVVW 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MME	NP_000893.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:341056	187/702 (27%)
Nepl7	NP_609577.2	M13	52..666	CDD:341056	186/703 (26%)