Protein Alignment MME and Nepl5

DIOPT Version :10

• Sequence 1: NP_000893.2
• Gene: MME / 4311
• HGNCID: 7154
• Length: 750
• Species: Homo sapiens
• Sequence 2: NP_609022.1
• Gene: Nepl5 / 33892
• FlyBaseID: FBgn0031808
• Length: 684
• Species: Drosophila melanogaster
• Alignment Length: 789
• Identity: 165/789 - (20%)
• Similarity: 305/789 - (38%)
• Gaps: 178/789 - (22%)

Human    35 VLLLTIIAVTMIALYATYDDGICKSSDCIKS-----AARLIQNMDATTEPCTDFFKYACGGW--- 91
            :|.|:::|..:.:|........|:.::..:|     |.:|...||....||.:|::||||.|
  Fly     1 MLKLSLVAWLIFSLAWRTTPTACRQTNAPQSVQEMLAEQLQSYMDTKARPCENFYQYACGNWQIQ 65

Human    92 ------LKRNVIPETSSRY----------GNFD-ILRDELEVVLKDVLQEPKTEDIVAVQKAKAL 139
                  |:.........||          |..| .:..:||::|:...:.....|...:::.:..
  Fly    66 QQEQHSLRDRDWTRDRQRYQGQMLPTDTLGLIDHSVNRKLELLLRRRNESSFESDSSILEQMRLY 130

Human   140 YRSCINESAIDSRGGEPLLKLLP--DIYGWPVATENWE-QKYGASWTAEKAIAQLNSKYGKKVLI 201
            ||||   ..:.....:..|:|||  :...||.....|. :::  .|.......:|:...|..:..
  Fly   131 YRSC---KRLKPYNLKKYLQLLPPSNSTQWPSVGRGWRPERF--DWITTLGRLRLHGLNGVLLRE 190

Human   202 NLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLPIDE 266
            .:....||  |.|:.|::::     |||...:..|   |.  |.::.::.:.:..|....|....
  Fly   191 EVLPRWDD--SRNYSIYVNK-----PSRQETQPMG---EG--AMIELLLDIGQTKRTANALARQV 243

Human   267 NQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIM 331
            :....:::::.|||.:        |...:..|.|....|.|::             ||:|..::
  Fly   244 DDFERKLHRLQELEDD--------EGPREMQLGYLDSYLPQLR-------------WLSFMRQV- 286

Human   332 STVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQN--LMSWRFIMDLVSSLSRTYKESRNAF 394
             .::..:.....:::....||..|..::...|...:.:  ::.|...:........:..|...|.
  Fly   287 -RIDSELDLRSTLIIENIPYLRALSDLMESESPDTVCSYIMLKWLAFLKQQGPADISRGECVAAL 350

Human   395 RKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLT 459
            |:|:    ...::|             .||:.:.:.    ||:..|..|..:::..|.|.|
  Fly   351 RRAM----PLASSW-------------LVGQQFSDP----ESESYVSSLFQRLKVRFGQIL---- 390

Human   460 WMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQ-NLKFSQS--- 520
               ||.:.|.....:.|.::            ||....|::.:.:.|..|::.| :::...|
  Fly   391 ---AENRMRLSPPLVHILQQ------------KLRAVRLQMGFFQTEEIEDVEQYHVRIDLSGHS 440

Human   521 ---KQLKKLREKVDKDEWISGAAVVNAFYSSG----------------------RNQIVFPAGIL 560
               .||..||::|:.:..:....|.|...|:|                      ||.::.|.|:|
  Fly   441 FYGNQLVLLRQRVEANHDLLYINVTNFANSTGSNLSYLSESWEASNSSPLYVRPRNLVLVPHGLL 505

Human   561 QPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSAS-NFKEQSQCMVY 624
            |.|.:....|....:..:|.|:.||:.||||..|.:::..|:::....:..|| .|::..||:..
  Fly   506 QLPIWHRNISALQQHAVMGFVLAHELAHGFDMLGMDYDAMGNIMGPVEEIGASRQFRQGLQCLQQ 570

Human   625 QYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNY-IKKNGEEKLLPGLDLNHKQLFFL 688
            |..            .|...:.|.:||...|..||..:... .|:...:.|||  ..:.:||||:
  Fly   571 QMA------------TGSKWIDEKLADFVALRLAYETFFGVRDKREPRDPLLP--QFSQRQLFFI 621

Human   689 NFAQVWCGTYRPEYAVNSIKTDV------------HSPGNFRIIGTLQNSAEFSEAFHCRKNSYM 741
            .|||.:||           :|.|            |:....|::.||.|..|||..|.|.|.:.|
  Fly   622 TFAQFFCG-----------RTPVLSPRSQSEAHLKHAADELRVMQTLANFEEFSREFGCDKKAKM 675

Human   742 NPEKKCRVW 750
            ...::||:|
  Fly   676 QASQRCRIW 684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MME	NP_000893.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:341056	152/736 (21%)
Nepl5	NP_609022.1	M13	48..682	CDD:341056	152/738 (21%)