Protein Alignment MME and Nep3

DIOPT Version :10

• Sequence 1: NP_000893.2
• Gene: MME / 4311
• HGNCID: 7154
• Length: 750
• Species: Homo sapiens
• Sequence 2: NP_523417.2
• Gene: Nep3 / 33005
• FlyBaseID: FBgn0031081
• Length: 786
• Species: Drosophila melanogaster
• Alignment Length: 765
• Identity: 285/765 - (37%)
• Similarity: 424/765 - (55%)
• Gaps: 61/765 - (7%)

Human    20 KKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGI------------------------CKSS 60
            |.::|    :.::..|:.:||..: :|.|:.  |.|.                        |.:.
  Fly    49 KTEKW----LLITTFVMAITIFTL-LIVLFT--DGGSSDATKHVLHVQPHQKDCPSGNELPCLNK 106

Human    61 DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQEP 125
            .||.:::.:::::|.|.:||.||:.|:|..|:|.|.|||..|.:|.|..|....::::::||::|
  Fly   107 HCIFASSEILKSIDVTVDPCDDFYGYSCNQWIKNNPIPEGKSTWGTFGKLEQMNQLIIRNVLEKP 171

Human   126 -KTEDIVAVQKAKALYRSCIN-ESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEKAI 188
             |:....|.:|||..|.||:: :..::..|.:|:..||..|.||.|....:..   |:||....:
  Fly   172 AKSFKSDAERKAKVYYESCLDADEHMEKLGAKPMNDLLLQIGGWNVTKSGYNV---ANWTMGHTL 233

Human   189 AQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYY-ECTGIYKEACTAYVDFMISV 252
            ..|::||....|....:|.|||||..|||.|||..|.||:.||| ..|..:::....|:::|..|
  Fly   234 KILHNKYNFNCLFGWAIGEDDKNSSRHVIQIDQGGLTLPTADYYNNKTDNHRKVLNEYIEYMTKV 298

Human   253 ARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEIN 317
            ..|      |..:|:....:|..|:..||::||.|...|||.:...:|:.|.|.|:...
  Fly   299 CVL------LGANESDARAQMIGVINFEKKLANITIPLEDRRNEEAMYHPMQLRQLSKL------ 351

Human   318 GKPF-SWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARD-----LQNLMSWRFI 376
             .|| :|.:..:..|..|...:|::|.||||||::|..|..|:.|....:     |.|.:.|:.:
  Fly   352 -APFLNWTDHFDNAMQMVGRRVTDDEVVVVYAPDFLKNLSDIILKMEQTEEGKITLNNYLVWQAV 415

Human   377 MDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVE 441
            ..|.|.||:.::::....||||.|:......||.|.:..|..:..|||.::|..||.||||...|
  Fly   416 RTLTSCLSKPFRDAYKGVRKALMGSDGGEEIWRYCVSDTNNVVGFAVGAIFVRQAFHGESKPAAE 480

Human   442 DLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDE 506
            .:||:|||.|...|.:|||:|.:|:::|.|||..|.:.||:||.|: :..:|:.:|.|||...:.
  Fly   481 QMIAEIREAFKMNLQNLTWVDKQTREKAIEKANQISDMIGFPDYIL-DPVELDKKYAELNITPNA 544

Human   507 YFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSN 571
            ||||.||...::....||:|.:.|:|..|......|||:|:..:|||||||||||.|||......
  Fly   545 YFENNIQVAIYNLKSNLKRLDQPVNKTNWGMTPQTVNAYYTPTKNQIVFPAGILQTPFFDINNPK 609

Human   572 SLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGG 636
            |||:|.:|:|:|||:||.|||.||.::|.|::..||..:|...|.|:|:|:..||..:..:   |
  Fly   610 SLNFGAMGVVMGHELTHAFDDQGREYDKFGNINRWWDSKSIERFNEKSECIARQYSGYKMN---G 671

Human   637 QHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKL-LPGLDLNHKQLFFLNFAQVWCGTYRP 700
            :.|||..||||||||||||..||.|||........:.| ||||:|.|.||||::||||||.:...
  Fly   672 RTLNGKQTLGENIADNGGLKAAYHAYQRTKSDRDVDILKLPGLNLTHSQLFFVSFAQVWCSSTTD 736

Human   701 EYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750
            |..:..::.|.|||..||:||||.|..||:|.|.|:....|||.:||.||
  Fly   737 ETNLLQMEKDPHSPSQFRVIGTLSNMKEFAEVFQCKPGKRMNPTEKCEVW 786

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MME	NP_000893.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		285/765 (37%)
		Stop-transfer sequence. /evidence=ECO:0000255	16..23		1/2 (50%)
		M13	79..748	CDD:341056	268/678 (40%)
Nep3	NP_523417.2	M13	123..784	CDD:341056	268/680 (39%)