Protein Alignment MME and goe

DIOPT Version :10

• Sequence 1: NP_000893.2
• Gene: MME / 4311
• HGNCID: 7154
• Length: 750
• Species: Homo sapiens
• Sequence 2: NP_573160.1
• Gene: goe / 32660
• FlyBaseID: FBgn0027528
• Length: 879
• Species: Drosophila melanogaster
• Alignment Length: 752
• Identity: 163/752 - (21%)
• Similarity: 298/752 - (39%)
• Gaps: 133/752 - (17%)

Human    27 LEISLSVLVLLLTIIAVTMIALYATYD----DGICKSSDCIKSAARLIQNMDATTEPCTDFFKYA 87
            |.::.:.|..||.:|.:.::|.:....    ..:|...:|::|:.:|:...:.:..||.:.:::|
  Fly   129 LYVTTACLCALLLLIIILLLAFWPEVPFYLRAPLCLDKECVESSRQLLLWANTSKSPCHETYEWA 193

Human    88 CGGWLKRNVIPETSSRYGN---FDILRDELEVVLKDVLQE-----------PKTEDIVAVQKAKA 138
            ||.:         :|.|.|   |.|.|.|......:..||           |.:::........:
  Fly   194 CGNF---------ASDYANHEYFVIKRGEWNYETYNEYQELNELNRFIAMLPNSQEGSVESTVSS 249

Human   139 LYRSCINESAIDSRGGEPLLK-LLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKKVLIN 202
            |||||.....:|....:.||| .:..:|||....::...:   ||..::.:..|.:|:|......
  Fly   250 LYRSCRETDVLDKSQSDLLLKRAINAVYGWQAFRDSNRLQ---SWEYKRVLVVLQAKHGIFPYYR 311

Human   203 LFVGTDDKNSVNHVIHIDQPRLGLPSRDYY------ECTGIYKEACTAYVDFMISVARLIRQEER 261
            :.|.....|..::||.:|:..||||.:.:|      |....||   ....||.|::. ::.:|..
  Fly   312 VTVENGFSNPHDYVITLDEGELGLPDKYFYGNDADEEVVRGYK---LLLRDFAINMG-IVSREAD 372

Human   262 LPIDENQLALEMNKVMELEKEIAN--ATAKPEDRNDPMLLYNK-MTLAQIQNNFSLEINGKPFSW 323
            |..|:         :...|:.|.|  ..|| .|.|.|:   || |.||      .|:|.......
  Fly   373 LFADD---------IFHYERRIVNHIEDAK-ADANRPI---NKLMRLA------DLKIKAPSLPI 418

Human   324 LNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYK 388
            |.....|..  ...||.:.:|:|..||.:..|..:|:....:.:.|.:.|.....::..||:.|:
  Fly   419 LESLQAIFP--KTKITEDTEVLVRDPEVMHALSVLLSTSDKKPINNFIVWSLARKMLPHLSKEYR 481

Human   389 ESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLY----------VEAAFAGESK-----H 438
            .....|..||||.|:....|..|:..|...:..||..|.          :.:...|.:|     .
  Fly   482 TLAETFDHALYGRTASYPRWLICSKVVRDWLPFAVDALQQQPPRQQFETMTSKSRGLNKTQGNEE 546

Human   439 VVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYK 503
            :::.:...:|.....:|:...|::...::..::|...::.:.|.||:::.....|...|.||...
  Fly   547 LLKLMFFSLRNQLKDSLEQAKWLEPAARQFIQKKLNEMRLQFGIPDEVLQQPTYLAQYYNELILN 611

Human   504 EDEYFENIIQNLKFSQSKQLKKLREKVDKDEWIS-------GAAVVNAFYSSGRNQIVFPAGILQ 561
            ...:.|::.....|.:|:..|||......|..:|       ..|:.   ||:..|.::....::.
  Fly   612 NVFFVEHLEWIWTFRRSQMEKKLGPLAILDVIVSEMYTRDNPQAIA---YSNKLNMLLVSKVLIS 673

Human   562 PPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQY 626
            ..::..:...::|:..||.    :|.....||...|     |:.:.||  :::..:.:..:.|..
  Fly   674 SNYYDYRYPVAVNFARIGT----DILEALIDNFSTF-----LLQFNTQ--STDISDAAPEIRYAQ 727

Human   627 GNFSWDLAGGQH---LNGINTLGENIADN-----GGLGQAYRAYQNYI---------------KK 668
            .:.:. ||.||.   ::.:|.|..|...:     .....|.||..|::               :.
  Fly   728 PDVNC-LAAGQPPRLVHELNELSSNALKSFHVTLSAARTAARALSNFVNAIDAGSAIQGSGIDQA 791

Human   669 NGEEKL-------LPGL-DLNHKQLFFLNFAQVWCGT 697
            |..|.|       :||| ..|..:||.|::.|..|.|
  Fly   792 NTYEALGLTRRLRIPGLRSFNENELFTLSYMQQHCST 828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MME	NP_000893.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:341056	153/696 (22%)
goe	NP_573160.1	GluZincin	184..>692	CDD:472708	120/547 (22%)