Protein Alignment MME and Nepl3

DIOPT Version :10

• Sequence 1: NP_000893.2
• Gene: MME / 4311
• HGNCID: 7154
• Length: 750
• Species: Homo sapiens
• Sequence 2: NP_608904.1
• Gene: Nepl3 / 326172
• FlyBaseID: FBgn0031678
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 720
• Identity: 136/720 - (18%)
• Similarity: 240/720 - (33%)
• Gaps: 224/720 - (31%)

Human    29 ISLSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLK 93
            :|||.|:|||.              ..:|.::..::...|::.:||...|||.:|:..:... ||
  Fly     8 LSLSWLLLLLC--------------STVCSANPNLEIMKRMLDDMDEKVEPCHNFYNSSQKN-LK 57

Human    94 RNVIPETSSRYGNFDILRDELEVVLKDVLQEPKTEDIVAVQKAKALYRSCINESAIDS------- 151
            .:.....|.:   |.:|.|.:|   .:|.::...|     :|.:.||:.|   |.::.
  Fly    58 WHAFATVSDQ---FQLLFDGIE---NEVFEKHSFE-----EKLQRLYKIC---STMERPSLLRYF 108

Human   152 ---RGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEK-----AIAQLNSKYG-KKVLINLFVGT 207
               :.||.|        .||..|..     |..|..||     |:|:|. :|| ..::..:.:..
  Fly   109 ELVKPGEDL--------NWPFLTPR-----GGKWPKEKFQWMEALARLR-RYGFNDIMFGMSIRQ 159

Human   208 DDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLPIDENQLALE 272
            |                  |:.|..:...::::...:...|:.|:     |...||   .:||.|
  Fly   160 D------------------PNSDSGQPIVVFEKKYDSLFRFIESL-----QNIGLP---PKLAKE 198

Human   273 MNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNIS 337
            :..:....:|:..:..|.|..........:::|.|      |||.|                 :|
  Fly   199 IAPLDNAIQEMYKSDMKFEHYARDAAPVKRISLGQ------LEIYG-----------------VS 240

Human   338 ITNEEDVVV---YAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALY 399
            :|...::|.   ::|:::..::.:   |..|.|||||:     .:.|.:...|..:|.:|    |
  Fly   241 LTKYLEIVFGRPFSPDFVVHVENL---YYLRGLQNLMT-----AVPSQVVANYLTARFSF----Y 293

Human   400 GTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAE 464
            ...:.......|...:..:||.|...|:.|.....:.....::...:|.:...|.|:
  Fly   294 IMFTFMKHGDSCVTTMRQSMEFASNLLFEERILGRKKLRSYQNQAGKIFDAIRQQLN-------- 350

Human   465 TKKRAEEKALAIKERIGYPDDIVSNDNKLN--------------------NEYLELNYKEDEYFE 509
              .|.|...|.:.     |.:|.....|||                    ..|.||.:.:||  |
  Fly   351 --IRLERNVLKLP-----PAEISLLQKKLNGLSLSIGNLPGKAGHRRFVTRYYKELEFADDE--E 406

Human   510 NIIQNLKFSQSK---QLKKLREKVDKDE--WISGAAVVNAF----YSSGRNQIVFPAGILQPPFF 565
            ....:||..:.:   :|..|.:...||.  .:....:.|.|    |....|.|......|....|
  Fly   407 LATAHLKVLEHRTRAELSLLDQPNFKDRRYMLHSYPISNFFFETAYEENGNTIYVAYDFLADASF 471

Human   566 SAQQSNSLNYGGIGMVIGHEITHGFD---------------DNGRNFNKDGDLVDWWTQ------ 609
            .....:......:|:..|.|:...||               |:.:......:.|..|||
  Fly   472 DPDSHDIFKVTPLGIRFGLEMLKSFDLFNCKHHKVNMLQLFDDNQITTAGDECVSAWTQDNLLSQ 536

Human   610 -----------------------QSASNFKEQS--QCMVYQYGNFSWD---------LAGGQHLN 640
                                   |...||...|  :...:::|..|:.         :.||..:|
  Fly   537 RDQYLVVLHLVHEAYFAEGSKFSQRQPNFTTMSLRELFFFRFGQSSFGQTLYFGSDFVEGGSPIN 601

Human   641 GINTL 645
            .:..|
  Fly   602 SLTRL 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MME	NP_000893.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:341056	124/670 (19%)
Nepl3	NP_608904.1	GluZincin	42..>434	CDD:472708	97/498 (19%)