Protein Alignment MME and Nep6

DIOPT Version :10

• Sequence 1: NP_000893.2
• Gene: MME / 4311
• HGNCID: 7154
• Length: 750
• Species: Homo sapiens
• Sequence 2: NP_572831.2
• Gene: Nep6 / 32234
• FlyBaseID: FBgn0030425
• Length: 655
• Species: Drosophila melanogaster
• Alignment Length: 773
• Identity: 172/773 - (22%)
• Similarity: 299/773 - (38%)
• Gaps: 175/773 - (22%)

Human    31 LSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRN 95
            ||.:..|:.|:.|.::.|.|..|   |:.        :|..:.||..:||.:|.:||||.|..
  Fly     5 LSSITRLVVILGVMLLKLAAAQD---CQQ--------QLDNDTDAEVKPCENFHQYACGNWYS-- 56

Human    96 VIPETSSRYGNFDILRDE----LEVVLKDVLQEPKTED--------IVAVQKAKALYRSCI---- 144
               .||.|......:|.:    |::.|...|:|..:.|        ..:..:...|||.|:
  Fly    57 ---NTSQRILGAHDMRSKWVANLKLQLIRYLEESSSTDSFSANTSVTTSTAQLGTLYRCCLLSGQ 118

Human   145 ----NESAIDSRGGE-PLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKKVLINLF 204
                ...|:...|.. |||                ....|.|:....|.|.|.: ||.:.|..|.
  Fly   119 SIRTYTDALSRSGANFPLL----------------ANHTGGSFDWVLANAALRT-YGAQGLWRLL 166

Human   205 VGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLPIDENQL 269
            |..:.:::...:.::..|:..|..||......:|:.    |:..::.         .|.:...:.
  Fly   167 VKDNWQSADQRIFYMLPPKFDLLGRDDELNEFLYQR----YLKILLL---------ELGLRVRRA 218

Human   270 ALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNF-SLEINGKPFSWLNFTNEIMST 333
            ||...|::..||.:....  |.|....::|....:|..:::.. .||:.       .:...|:.
  Fly   219 ALLAEKLVAFEKSLQKLL--PNDAEQTLVLRKPQSLKDLESQLPRLELK-------RYFETILE- 273

Human   334 VNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKAL 398
             .|...::..::|...:||..|:.:|.:::: |...|.:| .::.|.:     |.|.|      |
  Fly   274 -GIDWDSKTLLLVADLDYLQGLQRLLAEHTS-DPMVLSTW-LLLQLPA-----YFELR------L 324

Human   399 YGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDA 463
            :...........|...:...|...:|||.::.......:.|.:..|.||..:|           .
  Fly   325 HDDDKLGNQRNHCLEQLRKLMPGQLGRLQMQLVLGESYQDVYDTAIQQIAVLF-----------R 378

Human   464 ETKKRAEEKALAIKERIGYPDDIVSND---NKLNNEYLELNYKED-------------EYFENII 512
            :.|::.|   |.:.|...:.:|:|:.:   :||....|.....:|             ....|::
  Fly   379 DLKQQFE---LVLNETEVFNEDLVTRNLARDKLRAMRLLTPRLQDPINGGPGTPQLGGNCDANLL 440

Human   513 QNLKFSQSKQLKKLREKVDKDEWISGAAV---------VNAFYSSGRNQIVFPAGILQPPFFSAQ 568
            | |..||:|  .:.|:       :.|..|         |||:|....|:|..|.|::..|....|
  Fly   441 Q-LSLSQAK--LEYRQ-------VFGEPVTSVPADPLSVNAYYRLKLNRIELPLGLMATPLIQQQ 495

Human   569 QSNSLN-----YGGIGMVIGHEITHGFDDNGRNFNKDGDLVD-WWTQQSASNFKEQSQCMVYQYG 627
            .|...:     ..|:|.::.||:.|.||.:|.|::..|.|.: .|:.::...|..::.|.:
  Fly   496 CSKEADTRAKLSAGLGYILAHEMVHAFDLDGLNYDATGQLANGQWSARAIIRFGLRAGCYL---- 556

Human   628 NFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQ 692
                   |.::.|...|:.|||||..||..|...|::   ::|...|         :.||:.|||
  Fly   557 -------GVRYSNATLTVNENIADTEGLRLALDTYRH---RSGATNL---------RTFFVAFAQ 602

Human   693 VWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750
            .||||......::.     |:....|:...:.|..||.:.|.|:..|.|||..||.:|
  Fly   603 NWCGTVASTSGLSQ-----HAGHAERVNNVVGNMPEFGDTFECKATSQMNPVNKCHIW 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MME	NP_000893.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:341056	158/721 (22%)
Nep6	NP_572831.2	M13	40..653	CDD:341056	158/723 (22%)