Protein Alignment MME and Nep1

DIOPT Version :10

• Sequence 1: NP_000893.2
• Gene: MME / 4311
• HGNCID: 7154
• Length: 750
• Species: Homo sapiens
• Sequence 2: NP_511056.2
• Gene: Nep1 / 31547
• FlyBaseID: FBgn0029843
• Length: 849
• Species: Drosophila melanogaster
• Alignment Length: 702
• Identity: 290/702 - (41%)
• Similarity: 416/702 - (59%)
• Gaps: 27/702 - (3%)

Human    54 DGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVL 118
            |.||.:.:|:::||.|:..||..::||.|||:||||.|.|.:.|||..|....|::|.|:.:|:|
  Fly   170 DNICMTQECVRTAASLLSAMDLNSDPCEDFFQYACGTWNKMHPIPEDRSSISTFEVLSDQQQVIL 234

Human   119 KDVLQEPKTE-DIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASW 182
            :.||:||..| |..|..|||..::||::...|...|...|.::|..:.||||...||...  |..
  Fly   235 RAVLEEPIDERDNKATIKAKTFFKSCMDIPQIRKIGTGRLKQVLQSLGGWPVIERNWSPP--ADL 297

Human   183 TAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACT---- 243
            :.|:.:.||...|.:.|:|.|:||.|||||..:::.:||.:..|||||||     .||:..
  Fly   298 SVERLMGQLRLNYSEPVMIELYVGADDKNSSVNILQMDQLQYALPSRDYY-----LKESSANDRR 357

Human   244 AYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQI 308
            ||..:|..||.|      |..|....|.|:.||:..|.::.|.:....||:|..|:|.||.|.::
  Fly   358 AYHRYMTQVALL------LGADPATAAAELEKVVLFETQLVNVSLPEADRHDTSLVYRKMLLPEL 416

Human   309 QNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSW 373
            | ....|:     .|..:....:.. .|.:..:|.:|.|...|||::..||.....|.:.|.|.|
  Fly   417 Q-ELVPEV-----QWQEYLQAALGP-GIPLQEDEPLVTYGLHYLTEMGKILAHTDRRVVHNYMLW 474

Human   374 RFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKH 438
            |.:|.|:|.:...|:..|..|||.|.|..||...|.:|..:.|..:..|||.|::...|..|||.
  Fly   475 RLVMSLMSHMIDEYQRERVEFRKILMGIQSERTRWSQCVEWTNKKLGVAVGALFIRDNFNQESKE 539

Human   439 VVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYK 503
            |..::|..||..|.:.|.:..|||.||:..|:|||.::.|||||| ::::|..:|..||:.|...
  Fly   540 VALEMIHTIRAAFNELLAENDWMDDETRAVAKEKADSMNERIGYP-ELLTNATELEQEYVNLTIV 603

Human   504 EDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQ 568
            .|.:..|::..|::...|.|:.||:.|||::|.:..|||||||:..:|.||||||||||.|:|..
  Fly   604 PDNFINNVLSILQWESEKMLRLLRQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGILQPLFYSQH 668

Human   569 QSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDL 633
            ...||||||||:||||||||||||.||.|:|:|:::.||...:...|:|::||::.||..:..:.
  Fly   669 FPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYSRYKINE 733

Human   634 AGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTY 698
            . ...::|..|.||||||||||.||:|||:.:...:|.|:.||||::.|.||||||:||:|||:.
  Fly   734 V-DMFMDGRMTQGENIADNGGLKQAFRAYKKWETLHGREQQLPGLNMTHDQLFFLNYAQIWCGSM 797

Human   699 RPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750
            |||.|:..|::.|||||..|::|.|.||.:|:.|:.|...|.|||.:||.||
  Fly   798 RPEDALTKIRSAVHSPGFVRVLGPLSNSRDFASAYKCPLGSTMNPAEKCSVW 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MME	NP_000893.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:341056	278/673 (41%)
Nep1	NP_511056.2	M13	194..847	CDD:341056	278/674 (41%)