Protein Alignment MME and nep-2

DIOPT Version :10

• Sequence 1: NP_000893.2
• Gene: MME / 4311
• HGNCID: 7154
• Length: 750
• Species: Homo sapiens
• Sequence 2: NP_494343.2
• Gene: nep-2 / 188090
• WormBaseID: WBGene00020230
• Length: 736
• Species: Caenorhabditis elegans
• Alignment Length: 761
• Identity: 279/761 - (36%)
• Similarity: 420/761 - (55%)
• Gaps: 47/761 - (6%)

Human     9 DITDINTPKPKKKQRWTPL--EISLSVLVLLLTIIAVTMIALYATYDDG--ICKSSDCIKSAARL 69
            |..|..|..|  ..|||.:  .|:|.:|:|.|.::... |..|..|.|.  :|.|..|||:|:.:
 Worm     4 DEEDGTTKSP--GSRWTRIWAIIALILLILFLLVLGAA-IYFYINYKDSSDVCLSPGCIKTASVI 65

Human    70 IQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVL---QEPKTEDIV 131
            :.:|:::.:||.||:::|||.|:|.:.||:.:....||:.|..:||..||::|   .||...:..
 Worm    66 LSSMNSSVDPCDDFYEFACGQWIKGHPIPDDAPSVSNFENLGQDLEFALKELLDENDEPYDYETS 130

Human   132 AVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYG 196
            ||.|||..|..|:|||.|.........:::....|||  :...:.|..||  .|...|.:.:|:.
 Worm   131 AVGKAKYFYNLCLNESEILDNWRTTFDEVVKSFGGWP--SLGHQMKPDAS--IEMLYADMVAKFK 191

Human   197 KKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEER 261
            ...|....|..|||||..||:.||||:|.|.:||:|  .....|...||:..:..|..|
 Worm   192 ADSLFKATVQPDDKNSQRHVLLIDQPQLNLFARDFY--VAAENEERMAYLQLIRDVLIL------ 248

Human   262 LPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWLNF 326
            |..|..:..|:..::::.|..:||.|...|.|:|...||.|:||.:::.:.      ..|:|..|
 Worm   249 LDADRTRATLDAKEIIDFETALANITMADEHRHDIAELYTKITLGEMRRSL------PHFNWPLF 307

Human   327 TNEIMSTVN------ISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSW-RFIMDLVSSLS 384
            .|.:...::      |:..:..:||||..|:|.:|..::.:|..|.:.|.:.| .|...::..|.
 Worm   308 FNRMFKDLHEKNGKRITFDDNTEVVVYGYEFLRRLDVLIPQYDNRLIVNYLEWCWFFKTMLRDLP 372

Human   385 RTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIRE 449
            ..:..:...|.|.|.....:...|..|...:|..|..|...:||:..|..|:|..||::|:.|.|
 Worm   373 DPFALTIFKFYKTLNIMNVQKVRWHGCVTRINSLMPMATSAIYVKNHFDHEAKQQVEEMISLIME 437

Human   450 VFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQN 514
            .|:..|....|:..|||:.|::|...:|.:|||| |.:::...:||||.........|::.
 Worm   438 SFVDLLLSEDWLTKETKQTAKQKVNEMKRKIGYP-DYLNDPAAVNNEYKTFKVYPGHYYQT---- 497

Human   515 LKFS-----QSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLN 574
             |||     |...|:::.|.||::.|::|||:||||||...|:|:||||||||.|:|....:|:|
 Worm   498 -KFSFYEQYQRDVLERITEAVDRERWVAGAALVNAFYSPNTNEIIFPAGILQPVFYSKDFPSSMN 561

Human   575 YGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHL 639
            :||||:||||||||||||.||.::..|::..||...:.|.|:.::||:..||.::..|....| :
 Worm   562 FGGIGVVIGHEITHGFDDRGRLYDNLGNIRQWWDNATISKFEHKAQCIEKQYSSYVLDQINMQ-I 625

Human   640 NGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAV 704
            ||.:|.||||||||||.||||||:.|.|::.....|||::|.|.||||||:||:||||...:.|:
 Worm   626 NGKSTKGENIADNGGLKQAYRAYKKYEKRHSRPPRLPGVNLTHDQLFFLNYAQIWCGTMNDKEAI 690

Human   705 NSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750
            ..::|..||||..|:.|.|.||.:|::|::|...|.|||.:|||||
 Worm   691 RKLRTSEHSPGPIRVKGPLSNSYDFAKAYNCEPGSQMNPREKCRVW 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MME	NP_000893.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		4/10 (40%)
		Stop-transfer sequence. /evidence=ECO:0000255	16..23		1/6 (17%)
		M13	79..748	CDD:341056	252/683 (37%)
nep-2	NP_494343.2	M13	73..734	CDD:341056	252/685 (37%)