DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LpR2 and Lrp1b

DIOPT Version :9

Sequence 1:	NP_001097928.1	Gene:	LpR2 / 43105	FlyBaseID:	FBgn0051092	Length:	1064	Species:	Drosophila melanogaster
Sequence 2:	XP_006498522.1	Gene:	Lrp1b / 94217	MGIID:	2151136	Length:	4668	Species:	Mus musculus

Alignment Length:	752	Identity:	292/752 - (38%)
Similarity:	401/752 - (53%)	Gaps:	49/752 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 CDEKQFQCSTGECIPIRFVCDGSSDCPDHSDERLEECKFTESTCSQEQFRCGNGKCIPRRWVCDR 257
            |...:|:|....||..|:.|||..||.|.|||....| |..| |..:||:|.|.:|||:||:||.
Mouse   876 CKPGEFRCKNKHCIQARWKCDGDDDCLDGSDEDSVTC-FNHS-CPDDQFKCQNNRCIPKRWLCDG 938

  Fly   258 ENDCADGSDESTSQCRSHTCSPEEFACKSGEGECIPLSWMCDQNKDCRDGSDE-AQCN-RTCRS- 319
            .|||....|||...|.:.||..::|:|  |.|.|||.:|:||:..||.|.:|| |.|. .||..
Mouse   939 ANDCGSNEDESNQTCTARTCQADQFSC--GNGRCIPTAWLCDREDDCGDQTDEVASCEFPTCEPL 1001

  Fly   320 DEFTCGNGRCIQNRFKCDDDDDCGDGSDEKNCGEKAKCGSNFFACKSGPCIPNQWVCDGDSDCRN 384
            .:|.|.:||||.|::.||.||||||.|||..|..  .|..:.|.|.||.|||..|.||||:||.:
Mouse  1002 TQFICKSGRCISNKWHCDTDDDCGDRSDEVGCVH--SCLDDQFRCSSGRCIPGHWACDGDNDCGD 1064

  Fly   385 GEDEMQ-NCTVSLLNF---CQAGEFQCSDRITCLHKSWVCDGEADCPDGEDESQSN-CLKVSCRP 444
            ..||.. |||......   |...||||.....|:...|.||||.||.||.||...| .:::....
Mouse  1065 FSDETHINCTKEEARSPAGCIGNEFQCRPDGNCIPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHK 1129

  Fly   445 DQFQCNDQS-CIAGHLTCNGKRDCADGSDEIMCD--ISATPRTCNATTEFDCGG--GLCIPNAKV 504
            .:|.|.... ||.....|:|..||.|.|||..||  :...|:       :.|..  .:|:...|:
Mouse  1130 TKFSCRSTGRCINNAWVCDGDVDCEDQSDEEDCDSFLCGPPK-------YPCANDTSVCLQPEKL 1187

  Fly   505 CNRRKDCPNGEDEPAGKCGINECSSKNGGCMHQC-VNLEVGYRCECHDGYKLGADQHTCVDIDEC 568
            ||.|||||:|.|| ...|  :|||..||||.:.| |....|..|.|.:|::|..|..||..:|.|
Mouse  1188 CNGRKDCPDGSDE-GDLC--DECSLNNGGCSNHCSVVPGRGIVCSCPEGHQLKKDNRTCEIVDYC 1249

  Fly   569 ETPGICSQVCVNEIGAFKCECEAGYMRLLKNHTRCKASEGHASLLLARRHDIRKIALDRPEMTSI 633
            .:...|||||..:....||.|..|:.......:........|.::.:.||:||:|.|.:.:.:.:
Mouse  1250 ASHLRCSQVCEQQKHMVKCSCYEGWALGTDGESCTSVDSFEAFIIFSIRHEIRRIDLHKGDYSLL 1314

  Fly   634 VNSTKAATALDFVFRTGMIFWSDVATQSIYKAPIDEGNDRT---VVLTKSSVTSDGLAVDWIYNH 695
            |...:...||||.|...:::|:||....||:..:.|....:   ||:.....|.:||.||||..:
Mouse  1315 VPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGN 1379

  Fly   696 VYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGAS-PRIERAGMDGTH 759
            :|:.|::...||::..:||:...|:..:::.||:|||||..|.::|:||.|: ||||.|.|.|..
Mouse  1380 IYWIDSNLDQIEVSKLDGSLRATLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAG 1444

  Fly   760 RTAIITYDVK---WPNGITLDLVQKRLYWVDGKLNTISSSNYDGSQRHQVLYSGEYLRHPFSITT 821
            |..|.. |:|   ||||:|:|..::|:.|.|.:.:.|.|:.|||:...:::...|||.|||:::.
Mouse  1445 RKTIYK-DMKTGAWPNGLTVDHFERRIVWTDARSDAIYSAFYDGTNMIEIIRGHEYLSHPFAVSL 1508

  Fly   822 FEDYVYWTDWDKQAVFKANKFNGMDVEPVTATHMLEHPMVVHVYHPYRQPDGVNHCQSVNGH--C 884
            :...||||||....:.||||:.|.:|..:..|.  ..|..:.:|||.|||...|.|.:..|.  |
Mouse  1509 YGSEVYWTDWRTNTLAKANKWTGQNVSVIQKTS--AQPFDLQIYHPSRQPQAPNPCAANEGRGPC 1571

  Fly   885 SHLCLPAPRIN-ERSPRISCACPTGLKLMPDGLMCVE 920
            |||||    || .||  .:||||..:||..|...|.|
Mouse  1572 SHLCL----INHNRS--AACACPHLMKLSSDKKTCYE 1602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR2	NP_001097928.1	LDLa	193..224	CDD:197566	13/30 (43%)
		LDLa	235..267	CDD:197566	15/31 (48%)
		LDLa	277..313	CDD:238060	17/36 (47%)
		LDLa	356..388	CDD:197566	15/31 (48%)
		LDLa	400..432	CDD:197566	15/31 (48%)
		LDLa	442..476	CDD:238060	12/34 (35%)
		LDLa	484..517	CDD:197566	11/34 (32%)
		FXa_inhibition	527..562	CDD:291342	14/35 (40%)
		EGF_CA	564..594	CDD:214542	11/29 (38%)
		LY	675..715	CDD:214531	14/39 (36%)
		LY	717..760	CDD:214531	20/43 (47%)
		LY	763..803	CDD:214531	17/42 (40%)
		FXa_inhibition	877..918	CDD:291342	19/43 (44%)
Lrp1b	XP_006498522.1	LDLa	1167..1202	CDD:238060	14/42 (33%)
		FXa_inhibition	1207..1243	CDD:373209	14/35 (40%)
		LY	1311..1352	CDD:214531	12/40 (30%)
		LY	1358..1398	CDD:214531	13/39 (33%)
		LY	1402..1445	CDD:214531	20/42 (48%)
		LY	<1457..1489	CDD:214531	14/31 (45%)
		LY	1635..1670	CDD:214531
		LY	1672..1714	CDD:214531
		LY	1716..1755	CDD:214531
		LY	<1766..1797	CDD:214531
		FXa_inhibition	1869..1905	CDD:373209
		NHL	1944..2169	CDD:302697
		NHL repeat	1944..1983	CDD:271320
		LY	1978..2018	CDD:214531
		NHL repeat	1988..2025	CDD:271320
		NHL repeat	2029..2070	CDD:271320
		Ldl_recept_b	2039..2079	CDD:278487
		LY	2064..2106	CDD:214531
		NHL repeat	2073..2111	CDD:271320
		NHL repeat	2120..2159	CDD:271320
		FXa_inhibition	2178..2213	CDD:373209
		Ldl_recept_b	2361..2402	CDD:278487
		LY	2386..2428	CDD:214531
		LDLa	2545..2574	CDD:238060
		LDLa	2583..2617	CDD:238060
		LDLa	2622..2656	CDD:238060
		LDLa	2676..2705	CDD:238060
		LDLa	2713..2747	CDD:238060
		LDLa	2751..2784	CDD:238060
		LDLa	2791..2824	CDD:197566
		LDLa	2875..2908	CDD:197566
		LDLa	2922..2956	CDD:238060
		LDLa	63..95	CDD:238060
		LDLa	107..140	CDD:197566
		FXa_inhibition	194..224	CDD:373209
		LY	314..346	CDD:214531
		LY	350..392	CDD:214531
		LY	394..435	CDD:214531
		FXa_inhibition	514..547	CDD:373209
		LY	580..621	CDD:214531
		LY	622..661	CDD:214531
		LY	668..717	CDD:214531
		LY	718..760	CDD:214531
		FXa_inhibition	829..864	CDD:373209
		LDLa	917..950	CDD:238060	17/32 (53%)
		LDLa	957..989	CDD:197566	15/33 (45%)
		LDLa	1000..1033	CDD:238060	18/32 (56%)
		LDLa	1037..1070	CDD:238060	17/32 (53%)
		LDLa	1084..1119	CDD:238060	17/34 (50%)
		Ldl_recept_a	1131..1162	CDD:365841	12/30 (40%)
		cEGF	2979..3002	CDD:372248
		EGF_CA	2999..3033	CDD:214542
		LY	3066..3110	CDD:214531
		LY	3111..3149	CDD:214531
		LY	3154..3195	CDD:214531
		LY	3198..3237	CDD:214531
		FXa_inhibition	3308..3344	CDD:373209
		LDLa	3348..3379	CDD:197566
		LDLa	3388..3422	CDD:238060
		LDLa	3427..3462	CDD:238060
		LDLa	3467..3502	CDD:238060
		LDLa	3507..3541	CDD:238060
		LDLa	3546..3580	CDD:238060
		LDLa	3584..3618	CDD:238060
LDLa	3625..3659	CDD:238060
LDLa	3663..3698	CDD:238060
LDLa	3705..3737	CDD:238060
LDLa	3746..3782	CDD:238060
LDLa	3793..3827	CDD:238060
EGF_CA	3875..3909	CDD:214542
NHL	3972..4204	CDD:302697
NHL repeat	4002..4039	CDD:271320
NHL repeat	4060..4098	CDD:271320
Ldl_recept_b	4070..4110	CDD:393440
LY	4094..4133	CDD:214531
NHL repeat	4148..4186	CDD:271320
EGF_CA	4281..4315	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810