DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LpR2 and YNR065C

DIOPT Version :9

Sequence 1:	NP_001097928.1	Gene:	LpR2 / 43105	FlyBaseID:	FBgn0051092	Length:	1064	Species:	Drosophila melanogaster
Sequence 2:	NP_014463.1	Gene:	YNR065C / 855802	SGDID:	S000005348	Length:	1116	Species:	Saccharomyces cerevisiae

Alignment Length:	1137	Identity:	223/1137 - (19%)
Similarity:	355/1137 - (31%)	Gaps:	389/1137 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 AANSISP---------GTGSGMGIGMGHFG---SSINSVLNGNPLKFLNVSGKIGTPLDISLGL- 189
            |.:|:.|         |:||.. |..|.|.   |..||:.:...::::         :|.|...
Yeast    84 AISSVHPYKLINPTPDGSGSKF-IFKGTFATTDSETNSITSLKGVEYI---------IDFSAAFD 138

  Fly   190 SNYCDEKQFQ--------CSTG------------ECIPIRFVCDGSSDCPDHSDERLEECKFTES 234
            |..|:|:.|:        |..|            :|:..:...|.|.|     :.....|..::.
Yeast   139 SRTCEEEDFEDWDLADGKCVNGAKYKYRRRKQDAQCLVKKAFKDLSLD-----ETPCNSCGESDY 198

  Fly   235 TCSQEQFRCGNGKCIPRRWVCDRENDCADGSDEST----------SQCRS-HTCSPEEFACKSGE 288
            .||.|..|..||.|||...:....|.|....|:|.          .:|:: ....|.:..|..
Yeast   199 ECSFEFVRDANGLCIPDYNLIAFSNICDKSKDKSVLVEPLQLIKGDECKTPMKIEPVDIPCDE-- 261

  Fly   289 GECIPLSWMCDQNKDCRDG---------------SDEAQCNRTCRSDEFTCGNGRCIQNRFKCDD 338
               ||.....|:.....:.               :||:........|.:...:|.....||
Yeast   262 ---IPEEGSSDREIVTTENKFDFEIKFYQYFDTVADESLVMLNSIGDAYISHDGGQTIKRF---- 319

  Fly   339 DDDCGD-----------GSDEKNCGEKAKC------GSNFFACKSGPCIPNQWVCDGDSD-CRNG 385
             |..|:           .|.....|.|...      |.:|...|    :|.........| ....
Yeast   320 -DTNGEKIVEVVFNPYFNSSAYLFGSKGNIFSTHDRGHSFMIAK----LPEARQLGMPLDFSAKA 379

  Fly   386 EDEM-----QNCTVSLLNFCQAGEFQCSDRITCLHKSWVCDGEADC---------PDGED----- 431
            :|..     :||...|...|.|..:...|......:  :.|....|         |..|:
Yeast   380 QDTFIYYGGKNCESILSPECHAVAYLTKDGGETFTE--MLDNAIHCEFAGTLFEYPSNEEMVMCQ 442

  Fly   432 ----ESQSNCLKVSCRPDQFQCNDQ---SCIAGHLTCNGKRDCADGSDEIMCDISATPRTCNATT 489
                .|::..|..|.  |.||.:::   ..|.|:|:..|            ..|.|.|...|...
Yeast   443 VKKKSSETRSLVSSI--DFFQGDNKIIFENIIGYLSTGG------------YIIVAVPHEDNELR 493

  Fly   490 EFDCGGGLCIPNAKVCNRRKDCPNGEDEPAGKCGINECSSKNGGCMHQCVNLEVGYRCECHDGYK 554
            .:....|.....||.       |.|:|....:......|.|....:|...|||.|     ||...
Yeast   494 AYVTIDGTEFAEAKF-------PYGQDVSKQEAFTILGSEKGSIFLHLATNLESG-----HDFGN 546

  Fly   555 L---------------GADQHTCVDIDECETPGICSQVCVN------EIG------------AFK 586
            |               ..:::|...:|..:..|:...:..|      ::|            .|.
Yeast   547 LLKSNSNGTSFVTLEHAVNRNTFGYVDFEKVQGLEGIIITNIVSNREKVGENKEDEQLKTKITFN 611

  Fly   587 CECEAGYMRLLKNHTRCKASEGHASLLLARRHDIRKIALDR--------PEMTSIVNSTKAATAL 643
            ...:..:::..|     |.|||       ::.....::||:        .|...|.::..:.:||
Yeast   612 DGSDWNFLKPPK-----KDSEG-------KKFPCDSVSLDKCSLHLHGYTERKDIRDTYSSGSAL 664

  Fly   644 DFVFRTGMI--------------------FWSDVATQSIYKAPI-----DEGNDRTVVLTKSSVT 683
            ..:|..|.:                    .|::|.     |.|.     |.|.  .:||...:..
Yeast   665 GMMFGVGNVGDKLLPYEECSTFLTTDGGETWTEVK-----KGPHQWEYGDHGG--VLVLVPENAE 722

  Fly   684 SDGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGASP 748
            :|.::        |.||..| |.:...|.|.  ||||||.:.:||..||    .::.:.:
Yeast   723 TDSIS--------YSTDFGK-TWKDYKFCGD--KVLVKDIITVPRDSAL----RFLLFGE----- 767

  Fly   749 RIERAGMDGTHRTAIITYDVKWPNGITLDLVQKRLYWVDGKLNTISSSNYDGSQR-----HQVLY 808
             .:..| .|:.||..|.:...:......|:..|:.  .|.|.:.:      ||:.     ||.
Yeast   768 -AKNMG-SGSFRTYTIDFRNIFERQCEFDITGKKR--ADFKYSPL------GSRTGCLFGHQT-- 820

  Fly   809 SGEYLRH----------PFSITT------------FE-DYVYW--TDWDKQAVFKANKFNGMDVE 848
              |:||.          |.|..:            || ||.::  :|...:.|...:..||.|:
Yeast   821 --EFLRKTDEKCFIGNIPLSEFSRNVKNCSCTRQDFECDYNFYKASDGTCKLVKGLSSANGADI- 882

  Fly   849 PVTATHMLEHPMVVHVYHP--YRQ-PDGVNHCQ---SVNGHCS-HLCLPAPRINERSPRISCACP 906
                  ..:.|.::..|..  ||: |  ::.|:   .::.|.: |.| |.   .|::.|...:..
Yeast   883 ------CKKEPDLIEYYDSSGYRKIP--LSTCKGGLKLDAHLAPHPC-PG---KEKAFREKYSIN 935

  Fly   907 TG---------LKLMPDGLMCVEDLGIPTVRPTAPMHRTIEQSSNSTTKLPQDGYSETPVETKTG 962
            ||         |.::......|.|.||   |......|..|      .:|..||..|
Yeast   936 TGAYALVFVTILLVIFFAAWFVYDRGI---RRNGGFSRFEE------IRLGDDGLIE-------- 983

  Fly   963 NNRTDTSNQVHKSDAESENDYVEIALHVIASL----------AGTALVASVIYVVYRRCTRAVNS 1017
            |||||          ...|..|.:.|.:  ||          ||.|..:|.:...:.
Yeast   984 NNRTD----------RVVNIIVRLGLCI--SLITKSAFQRTKAGVARFSSKLRARFG-------- 1028

  Fly  1018 MNFENPVYHKTTEDHFSLEKNGTPHIYAAAND 1049
             |.:.|.|....:..||.|.:|   ::..|||
Yeast  1029 -NRKGPTYSSLLQGQFSDESDG---LHEDAND 1056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR2	NP_001097928.1	LDLa	193..224	CDD:197566	9/50 (18%)
		LDLa	235..267	CDD:197566	11/31 (35%)
		LDLa	277..313	CDD:238060	7/50 (14%)
		LDLa	356..388	CDD:197566	5/38 (13%)
		LDLa	400..432	CDD:197566	7/49 (14%)
		LDLa	442..476	CDD:238060	7/36 (19%)
		LDLa	484..517	CDD:197566	6/32 (19%)
		FXa_inhibition	527..562	CDD:291342	10/49 (20%)
		EGF_CA	564..594	CDD:214542	5/47 (11%)
		LY	675..715	CDD:214531	10/39 (26%)
		LY	717..760	CDD:214531	12/42 (29%)
		LY	763..803	CDD:214531	7/39 (18%)
		FXa_inhibition	877..918	CDD:291342	10/53 (19%)
YNR065C	NP_014463.1	VPS10	<1..260	CDD:214740	40/190 (21%)
YNR065C	NP_014463.1	VPS10	295..922	CDD:214740	137/726 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5986
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950