Protein Alignment LpR2 and si:dkey-88l16.3

DIOPT Version :10

• Sequence 1: NP_001097928.1
• Gene: LpR2 / 43105
• FlyBaseID: FBgn0051092
• Length: 1064
• Species: Drosophila melanogaster
• Sequence 2: XP_073770595.1
• Gene: si:dkey-88l16.3 / 796880
• ZFINID: ZDB-GENE-030131-6015
• Length: 3896
• Species: Danio rerio
• Alignment Length: 927
• Identity: 289/927 - (31%)
• Similarity: 405/927 - (43%)
• Gaps: 205/927 - (22%)

  Fly   160 SINSVLNGNPLKFLNVSGKIGTPLDISLGLSNYCDEKQFQCSTGECIPIRFVCDGSSDCPDHSDE 224
            ||....|.:|||.|.....           |.:|.|      |.:|:|...:|||..|||..:||
Zfish  2575 SIPDASNADPLKTLGCRSP-----------SMFCKE------TSKCMPESQLCDGKVDCPSGADE 2622

  Fly   225 RLEECKFTESTCSQ-EQFRC-GNGKCIPRRWVCDRENDCADGSDE-----STSQCRSHT------ 276
                 :|...:||. :.|.| ...||:.:..|||..:.|||||||     ...||...|
Zfish  2623 -----QFCIYSCSDPDHFLCKDKRKCVHKAVVCDGYSHCADGSDEYQCPTCALQCDQKTVCLTKQ 2682

  Fly   277 --------------------------------CSPEEFACKSGEGECIPLSWMCDQNKDCRDGSD 309
                                            |......|..|: ||:.|..:||..|||:||||
Zfish  2683 QRCDGKPDCRDGSDEKDCYTGGVIASTSLPLRCPLGSKPCMDGK-ECVLLDHLCDGEKDCKDGSD 2746

  Fly   310 EAQCNRTCRSDEFTCGNGR-CIQNRFKCDDDDDCGDGSDEKNCGE-----KAKCGSNFFACKSGP 368
            |..|.|.|:..:|.|.:|| ||..:|.||....|.|.|||.||.:     :.:|.:      ...
Zfish  2747 ERTCERKCKKGQFQCSHGRKCIDMKFVCDGTPQCQDRSDEANCMKLSDECRHQCDN------KTR 2805

  Fly   369 CIPNQWVCDGDSDCRNGEDEMQNCTVSLLNFCQAGEFQCSD------------------------ 409
            |:|..::|||:.||.:|.|| .||.|..   |....||||:
Zfish  2806 CVPETFLCDGEKDCVDGTDE-ANCVVEP---CSGDRFQCSNGQCVALSLRCDGYADCRDHTDEKG 2866

  Fly   410 ---------------RITCLHKSWVCDGEADCPDGEDESQSNCLKVSCRPDQFQCNDQS-CIAGH 458
                           ...||.|.|:|||:.||.||.||.......:.|...|:.|..:: |||..
Zfish  2867 CPQPPHCPLDHRCPHTHECLLKEWLCDGDKDCSDGSDERNCKATPLKCGEFQWSCASRTQCIAKT 2931

  Fly   459 LTCNGKRDCADGSDEIMCDISATPRTCNATTEFDCGGGLCIPNAKVCNRRKDCPNGEDEPAGKCG 523
            ..|:|.:||.|.|||..|..:..|     |..|.||.|.|:....|||:..||.:|.||..| |.
Zfish  2932 WRCDGMKDCQDESDESGCGQTKCP-----THLFQCGSGECMDPDLVCNKASDCADGSDEGVG-CL 2990

  Fly   524 INECSSKNG-GCMHQCVNLEVGYRCECHDGYKLGADQHTCVDIDECE--TPGICSQVCVNEIGAF 585
            .|.|||... .|.|.|:|...|.||.|..|:||.:|..:|||||||:  .|..||..|.|.:|::
Zfish  2991 KNNCSSPGSPSCQHYCINTPHGARCGCKTGFKLHSDGLSCVDIDECKEIQPAACSHKCFNRLGSY 3055

  Fly   586 KCECEAGYMRLLKNHTRCKASEGHASLLLARRHDIRKIALDRPEMTSIVNST----KAATALDFV 646
            .|:|...::.....|: ||.:: ..|||::.:.::..:.|   ...||...|    |...:||:.
Zfish  3056 ICQCHPEFLLEPDGHS-CKTAD-EPSLLVSEQDELLNMGL---RSFSIQTLTAPGRKPIFSLDYD 3115

  Fly   647 FRTGMIFWSDVATQSI-YKAPIDEGNDRTVVLTKSSVTSDGLAVDWIYNHVYFTD---THKCTIE 707
            .|...::|:.:..:|| |....::.|..|:|   ..|.||.:|:||:..::|:.|   .....:.
Zfish  3116 LRERRVYWASLEDESIKYAFHGEKDNTGTIV---KGVKSDCIAIDWMGRNLYWVDGVAGQILAVR 3177

  Fly   708 LTN--FEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGASPRIERAGMDGTHRTAIITYDVKW 770
            |||  .......|::.:.|..|.|:.|.|.:|.|.||..|...:|.|:.|||:.|.|:|...:.|
Zfish  3178 LTNSVVHPQNYVVVLDEDLKQPNSLVLLPQKGIMLWSQVGGQAQIGRSSMDGSDRRAVIRRGLNW 3242

  Fly   771 PNGITLDLVQKRLYWVDGKLNTISSSNYDGSQRHQVLYSGEYLRHPFSITTFEDYVYWTDWDKQA 835
            |..:|:|::..||||.|.||..|.|:..||.....:..|  ::..|.|:..|.|.:||:|..:::
Zfish  3243 PVSVTVDILTDRLYWTDKKLGCIGSATLDGENIRFLQLS--HMPSPLSMAVFNDMIYWSDTQRRS 3305

  Fly   836 VFKANKFNGMD-----VEPVTATHMLEHPMVVHVYHPYRQPDGVNHCQSVNGHCSHLCLPAPRIN 895
            |..|||..|.:     ..|       ..|..:.|.||.:||:..|.|||:  ||||:||.||.:
Zfish  3306 VQGANKLTGKNRKVFLKRP-------GQPFALKVVHPLQQPNVPNPCQSL--HCSHVCLLAPGL- 3360

  Fly   896 ERSPRISCACPTGLKLMPDGLMC---VED-------LGIPTVRPTA-------------PMHRTI 937
                :..|.|||...|..|||.|   ::|       |.:.|:....             |.||:
Zfish  3361 ----KAVCRCPTRAPLAADGLTCGSTLDDSSSYLMLLSLTTITQIFTKSMQSEVGLKQWPNHRS- 3420

  Fly   938 EQSSNSTTKLPQDGYSE 954
                     ||..|.||
Zfish  3421 ---------LPLLGVSE 3428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LpR2	NP_001097928.1	LDLa	193..224	CDD:197566	11/30 (37%)
		LDLa	235..267	CDD:197566	14/33 (42%)
		LDLa	277..313	CDD:238060	16/35 (46%)
		LDLa	356..388	CDD:197566	9/31 (29%)
		LDLa	400..432	CDD:197566	16/70 (23%)
		LDLa	442..476	CDD:238060	14/34 (41%)
		LDLa	484..517	CDD:197566	12/32 (38%)
		FXa_inhibition	527..562	CDD:464251	15/35 (43%)
		EGF_CA	564..594	CDD:214542	13/31 (42%)
		LY	675..715	CDD:214531	12/44 (27%)
		LY	717..760	CDD:214531	16/42 (38%)
		LY	763..803	CDD:214531	16/39 (41%)
		Ldl_recept_b	782..828	CDD:459654	16/45 (36%)
		Ldl_recept_b	824..866	CDD:459654	12/46 (26%)
		FXa_inhibition	877..918	CDD:464251	19/40 (48%)
si:dkey-88l16.3	XP_073770595.1	None