Protein Alignment LpR2 and LRP8

DIOPT Version :10

• Sequence 1: NP_001097928.1
• Gene: LpR2 / 43105
• FlyBaseID: FBgn0051092
• Length: 1064
• Species: Drosophila melanogaster
• Sequence 2: NP_004622.2
• Gene: LRP8 / 7804
• HGNCID: 6700
• Length: 963
• Species: Homo sapiens
• Alignment Length: 982
• Identity: 351/982 - (35%)
• Similarity: 498/982 - (50%)
• Gaps: 177/982 - (18%)

  Fly   130 QLKHLAPAAANSISPGTGSGMGIGMGHFGSSINSVLNGNPLKFLNVSGKIGTPLDISLGLSNYCD 194
            ||:|||.|||:.:..|.|                     |.|                    .|:
Human    25 QLQHLAAAAADPLLGGQG---------------------PAK--------------------DCE 48

  Fly   195 EKQFQCSTGECIPIRFVCDGSSDCPDHSDERLEECKFTESTCSQEQFRCGNGKCIPRRWVCDREN 259
            :.||||....|||..:.||...||.|||||  ::|  .:.||:...|.|.||.||..||.||.|.
Human    49 KDQFQCRNERCIPSVWRCDEDDDCLDHSDE--DDC--PKKTCADSDFTCDNGHCIHERWKCDGEE 109

  Fly   260 DCADGSDESTSQCRSHTCSPEEFACKSGEGECIPLSWMCDQNKDCRDGSDEAQCNRTCRSDEFTC 324
            :|.||||||.:.|....|..|:.:|.....:|:|.||.||..|||..|:|||.|...|...||.|
Human   110 ECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQC 174

  Fly   325 GNGRCIQNRFKCDDDDDCGDGSDEKNCGEKAKCGSNFFAC---KSGPCIPNQWVCDGDSDCRNGE 386
            ||..|:...|.||.||||||||||:.|.:.| ||...|.|   ..|.|||.:||||...||.:..
Human   175 GNRSCLAAVFVCDGDDDCGDGSDERGCADPA-CGPREFRCGGDGGGACIPERWVCDRQFDCEDRS 238

  Fly   387 DEMQN---------------CTVSLLNFCQAGEFQCSDRITCLHKSWVCDGEADCPDGEDESQSN 436
            ||...               |..:....|::||        |:|..|.|||:.||.|..||  ::
Human   239 DEAAELCGRPGPGATSAPAACATASQFACRSGE--------CVHLGWRCDGDRDCKDKSDE--AD 293

  Fly   437 CLKVSCRPDQFQCNDQSCIAGHLTCNGKRDCADGSDEIMCDISATPRTCNATTEFDCGGGLCIPN 501
            |...:||.|:|||.|                                            |.|:..
Human   294 CPLGTCRGDEFQCGD--------------------------------------------GTCVLA 314

  Fly   502 AKVCNRRKDCPNGEDEPAGKCGINECSSKNGGCMHQCVNLEVGYRCECHDGYKLGADQHTCVDID 566
            .|.||:.:|||:|.||.....|:|||...||||.|.|.:|::|:.|.|..|::| .||.||.|||
Human   315 IKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGDID 378

  Fly   567 ECETPGICSQVCVNEIGAFKCECEAGY-MRLL-KNHTRCKASEGHA-SLLLARRHDIRKIALDRP 628
            ||:.|..|||:|||..|.|||||..|| |.|| ||   |||:.|.: ||:...||::|:|.|.:.
Human   379 ECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKN---CKAAAGKSPSLIFTNRHEVRRIDLVKR 440

  Fly   629 EMTSIVNSTKAATALDFVFRTGMIFWSDVATQSIYKAPIDEGND---RTVVLTKSSVTSDGLAVD 690
            ..:.::...|...|||....|..|:|.|::.:.||.|.:|:.:|   :.|::.:...:.:|||||
Human   441 NYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVD 505

  Fly   691 WIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGASPRIERAGM 755
            |::.|:|:||:...||.:...:|...:.|...:|..||:||:||:.|:|||||||...:||::|:
Human   506 WVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGL 570

  Fly   756 DGTHRTAIITYDVKWPNGITLDLVQKRLYWVDGKLNTISSSNYDGSQRHQVLYSGEYLRHPFSIT 820
            :|..|..:::.:::|||||||||:.:||||||.||:.:||.::.|..|..::.|.::|.|||.|.
Human   571 NGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIA 635

  Fly   821 TFEDYVYWTDWDKQAVFKANKFNGMDVEPVTATHMLEHPMVVHVYHPYRQPDGVNHCQ-SV--NG 882
            .|||.|:|||.:.:|:|.||:.||:::..:...  |.:|..:.::|..:||...:.|: ||  ||
Human   636 VFEDKVFWTDLENEAIFSANRLNGLEISILAEN--LNNPHDIVIFHELKQPRAPDACELSVQPNG 698

  Fly   883 HCSHLCLPAPRINERSPRISCACPTGLKLMPDGLMCVEDLGIPTVRPTAPMHRTIEQSSNSTTKL 947
            .|.:||||||:|:..||:.:||||..:.|.||...|..   .|....|..:..|:.::..:||:.
Human   699 GCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYR---APQSTSTTTLASTMTRTVPATTRA 760

  Fly   948 P---------QDGYSETP----------------------VETKTGNNRTDTSNQVHKSDAESEN 981
            |         |:..:|||                      :...|.|:....:|:    |::..:
Human   761 PGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANE----DSKMGS 821

  Fly   982 DYVEIALHVIASLAGTALVASVIYVVYRRCTRA-VNSMNFENPVYHKTT--EDHFSLEKNGTP-- 1041
            ......:.:|..:...||:....|:::|...|. ..||||:||||.|||  ||...|....|.
Human   822 TVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQI 886

  Fly  1042 -HIYAAA 1047
             |:|.||
Human   887 GHVYPAA 893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LpR2	NP_001097928.1	LDLa	193..224	CDD:197566	15/30 (50%)
		LDLa	235..267	CDD:197566	17/31 (55%)
		LDLa	277..313	CDD:238060	16/35 (46%)
		LDLa	356..388	CDD:197566	14/34 (41%)
		LDLa	400..432	CDD:197566	12/31 (39%)
		LDLa	442..476	CDD:238060	7/33 (21%)
		LDLa	484..517	CDD:197566	9/32 (28%)
		FXa_inhibition	527..562	CDD:464251	15/34 (44%)
		EGF_CA	564..594	CDD:214542	20/30 (67%)
		LY	675..715	CDD:214531	14/39 (36%)
		LY	717..760	CDD:214531	20/42 (48%)
		LY	763..803	CDD:214531	20/39 (51%)
		Ldl_recept_b	782..828	CDD:459654	22/45 (49%)
		Ldl_recept_b	824..866	CDD:459654	13/41 (32%)
		FXa_inhibition	877..918	CDD:464251	22/43 (51%)
LRP8	NP_004622.2	LDLa	47..81	CDD:238060	17/35 (49%)
		LDLa	85..117	CDD:197566	17/31 (55%)
		LDLa	127..163	CDD:238060	16/35 (46%)
		LDLa	206..240	CDD:197566	14/33 (42%)
		Ldl_recept_a	262..294	CDD:395011	14/41 (34%)
		Ldl_recept_a	298..333	CDD:395011	18/78 (23%)
		FXa_inhibition	340..374	CDD:464251	15/34 (44%)
		EGF_CA	376..406	CDD:214542	19/29 (66%)
		LY	445..480	CDD:214531	11/34 (32%)
		LDL-receptor class B 1	462..508		15/45 (33%)
		LY	489..531	CDD:214531	14/41 (34%)
		LDL-receptor class B 2	509..551		15/41 (37%)
		LDL-receptor class B 3	552..595		22/42 (52%)
		Ldl_recept_b	552..592	CDD:459654	19/39 (49%)
		LY	576..618	CDD:214531	20/41 (49%)
		LDL-receptor class B 4	596..639		19/42 (45%)
		Ldl_recept_b	639..679	CDD:459654	13/41 (32%)
		LDL-receptor class B 5	640..681		13/42 (31%)
		FXa_inhibition	697..734	CDD:464251	19/36 (53%)
		Clustered O-linked oligosaccharides	740..798		9/57 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	754..815		9/60 (15%)