DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LpR2 and SORL1

DIOPT Version :9

Sequence 1:	NP_001097928.1	Gene:	LpR2 / 43105	FlyBaseID:	FBgn0051092	Length:	1064	Species:	Drosophila melanogaster
Sequence 2:	NP_003096.2	Gene:	SORL1 / 6653	HGNCID:	11185	Length:	2214	Species:	Homo sapiens

Alignment Length:	1023	Identity:	284/1023 - (27%)
Similarity:	384/1023 - (37%)	Gaps:	318/1023 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 NYCDEKQFQCSTGECIPIRFVCDGSSDCPDHSDERLEECKFTESTCSQE-QFRC-GNGKCIPRRW 253
            |.|...|::||.|.||...:.||..:||.|.||||  .|..|  .|..: |||| .:|.|||..:
Human  1076 NTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDER--NCPTT--ICDLDTQFRCQESGTCIPLSY 1136

  Fly   254 VCDRENDCADGSDESTSQCRSHTCSPEEFACKSGEGECIPLSWMCDQNKDCRDGSDEAQCN---R 315
            .||.|:||.|.|||  |.|..|.|..:|:.|.|  |.||..||:||.:.||||.||||.|.   .
Human  1137 KCDLEDDCGDNSDE--SHCEMHQCRSDEYNCSS--GMCIRSSWVCDGDNDCRDWSDEANCTAIYH 1197

  Fly   316 TCRSDEFTCGNGRCIQNRFKCDDDDDCGDGSDEK--NCGEKAKCGSNFFACKSGPCIPNQWVCDG 378
            ||.:..|.|.||.||..|:.||.|.||.|||||.  || || ||  |.|.|.:|.|||:...|||
Human  1198 TCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNC-EK-KC--NGFRCPNGTCIPSSKHCDG 1258

  Fly   379 DSDCRNGEDEMQNCTVSLLNFCQAGEFQCSDRITCLHKSWVCDGEADCPDGEDE-------SQSN 436
            ..||.:|.|| |:|.....:|.   :|.|.:|..||..|.||||...|.||.||       ||..
Human  1259 LRDCSDGSDE-QHCEPLCTHFM---DFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDP 1319

  Fly   437 CLKVSCRPDQFQCNDQSCIAGHLTCNGKRDCADGSDEIMCDISATPRTCNATTEFDCGGGLCIPN 501
            .....|....|||.:..||:....|:|..||.|.|||..|:.......|:...:|.|..|.||||
Human  1320 EFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPN 1384

  Fly   502 AKVCNRRKDCPNGEDEPAGKCGIN------------------ECSSKNGGCMHQCVNLEVGYRCE 548
            ...|:|..||.:..||.  .||.:                  .|||  |.|:......: ||| :
Human  1385 RWKCDRENDCGDWSDEK--DCGDSHILPFSTPGPSTCLPNYYRCSS--GTCVMDTWVCD-GYR-D 1443

  Fly   549 CHDGYKLGADQHTC---VDIDECETP---GICSQVCVNEIGAFKCECEAGYMRLLKNHTRCKASE 607
            |.|    |:|:..|   .::....||   |.|.:        |:.||... ...:.|..||   :
Human  1444 CAD----GSDEEACPLLANVTAASTPTQLGRCDR--------FEFECHQP-KTCIPNWKRC---D 1492

  Fly   608 GHASLLLARRHDIRKIALDRPEMTSIVNSTKAATALDFVFRTG--MIFWS-------DVATQSIY 663
            ||        .|.:.   .|.|.....:||....:.:|....|  .|..|       |.:.:|..
Human  1493 GH--------QDCQD---GRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDE 1546

  Fly   664 KAPIDEGNDRTVVLTKSSV-----TSD---GLAVDW-----------IYNHVYF----------T 699
            ||..||       ||...|     |:|   .:.:.|           :|| ||:          .
Human  1547 KACSDE-------LTVYKVQNLQWTADFSGDVTLTWMRPKKMPSASCVYN-VYYRVVGESIWKTL 1603

  Fly   700 DTHKCTIELTNFEGSMGKVLVKDSL-----------------------------DIPRSIALD-- 733
            :||      :|...::.|||..|:.                             |.||::.|.
Human  1604 ETH------SNKTNTVLKVLKPDTTYQVKVQVQCLSKAHNTNDFVTLRTPEGLPDAPRNLQLSLP 1662

  Fly   734 -PIEGWM--YWSDWGASPRIERAG---------------MDGTHRTAIITYDVKWPNGITLDLVQ 780
             ..||.:  :|     :|.|...|               |..:.|.|....::|       :|:.
Human  1663 REAEGVIVGHW-----APPIHTHGLIREYIVEYSRSGSKMWASQRAASNFTEIK-------NLLV 1715

  Fly   781 KRLY--------------WVDGK-LNTISSSNYDGSQRHQVLYSGEYLRHPFSITTFED-----Y 825
            ..||              |.|.| :.||..........|...|...||  .|::|...|     |
Human  1716 NTLYTVRVAAVTSRGIGNWSDSKSITTIKGKVIPPPDIHIDSYGENYL--SFTLTMESDIKVNGY 1778

  Fly   826 V---YWT-DWDKQAVFKANKFNGMDVEPVTATHMLEHPMVVHVYHPYRQPDGVNHCQSVNGHCSH 886
            |   :|. |..||.....| |.|         .:|.|.:                 .::..|.|:
Human  1779 VVNLFWAFDTHKQERRTLN-FRG---------SILSHKV-----------------GNLTAHTSY 1816

  Fly   887 LCLPAPRINERSPRISCACPTGLKLMPDGLMCVEDLGIPTVRPTAPMHRTIEQSSNSTTKLPQDG 951
                         .||....|.|   .|..:..|.:....|||.||             .|....
Human  1817 -------------EISAWAKTDL---GDSPLAFEHVMTRGVRPPAP-------------SLKAKA 1852

  Fly   952 YSETPVE-TKTG-------------------NNRTDTSNQVHKSDAESENDYVEIALHVIASLAG 996
            .::|.|| |.||                   |.::.|::..:|:...|:::.....:.|:....|
Human  1853 INQTAVECTWTGPRNVVYGIFYATSFLDLYRNPKSLTTSLHNKTVIVSKDEQYLFLVRVVVPYQG 1917

  Fly   997 TA---LVASVI----------YVVYRRCTRAVNSMNFENPVYHKTTED 1031
            .:   :|..:|          :||:...|..|  :.:|:| |....:|
Human  1918 PSSDYVVVKMIPDSRLPPRHLHVVHTGKTSVV--IKWESP-YDSPDQD 1962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR2	NP_001097928.1	LDLa	193..224	CDD:197566	13/30 (43%)
		LDLa	235..267	CDD:197566	16/33 (48%)
		LDLa	277..313	CDD:238060	19/35 (54%)
		LDLa	356..388	CDD:197566	15/31 (48%)
		LDLa	400..432	CDD:197566	13/31 (42%)
		LDLa	442..476	CDD:238060	14/33 (42%)
		LDLa	484..517	CDD:197566	12/32 (38%)
		FXa_inhibition	527..562	CDD:291342	12/34 (35%)
		EGF_CA	564..594	CDD:214542	7/32 (22%)
		LY	675..715	CDD:214531	13/68 (19%)
		LY	717..760	CDD:214531	15/91 (16%)
		LY	763..803	CDD:214531	9/54 (17%)
		FXa_inhibition	877..918	CDD:291342	7/40 (18%)
SORL1	NP_003096.2	Cell attachment site. /evidence=ECO:0000255	63..65
		VPS10	124..753	CDD:214740
		BNR 1	136..147
		BNR 2	232..243
		BNR 3	441..452
		BNR 4	521..532
		BNR 5	562..573
		LY	780..821	CDD:214531
		LDL-receptor class B 1	800..843
		LY	824..866	CDD:214531
		LDL-receptor class B 2	844..887
		LY	868..910	CDD:214531
		LDL-receptor class B 3	888..932
		Ldl_recept_b	890..929	CDD:278487
		LY	913..953	CDD:214531
		LDL-receptor class B 4	933..970
		LDL-receptor class B 5	971..1013
		LDLa	1078..1112	CDD:238060	16/35 (46%)
		LDLa	1120..1153	CDD:238060	18/34 (53%)
		Ldl_recept_a	1157..1192	CDD:278486	19/36 (53%)
		LDLa	1198..1230	CDD:197566	17/31 (55%)
		LDLa	1240..1271	CDD:238060	16/31 (52%)
		LDLa	1281..1308	CDD:197566	13/26 (50%)
		LDLa	1325..1359	CDD:238060	14/33 (42%)
		LDLa	1373..1403	CDD:238060	13/31 (42%)
		LDLa	1419..1453	CDD:238060	12/41 (29%)
		LDLa	1471..1506	CDD:238060	12/57 (21%)
		LDLa	1513..1546	CDD:197566	6/32 (19%)
		FN3	1557..>1628	CDD:238020	15/77 (19%)
		FN3	1651..1742	CDD:238020	20/102 (20%)
		FN3	1749..1829	CDD:214495	24/124 (19%)
		FN3	1934..2021	CDD:238020	8/32 (25%)
		FN3	2025..2112	CDD:238020
		Potential nuclear localization signal for the C-terminal fragment generated by PSEN1. /evidence=ECO:0000305\|PubMed:16531402	2161..2164
		Endocytosis signal. /evidence=ECO:0000255	2172..2177
		Required for efficient Golgi apparatus -endosome sorting. /evidence=ECO:0000269\|PubMed:17646382	2190..2214
		Required for interaction with GGA1 and GGA2. /evidence=ECO:0000269\|PubMed:11821067	2201..2214
		DXXLL motif involved in the interaction with GGA1. /evidence=ECO:0000269\|PubMed:20015111	2208..2212
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5986
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.760