DRSC/TRiP Functional Genomics Resources

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Protein Alignment LpR2 and lrp5

DIOPT Version :9

Sequence 1:NP_001097928.1 Gene:LpR2 / 43105 FlyBaseID:FBgn0051092 Length:1064 Species:Drosophila melanogaster
Sequence 2:XP_009296098.1 Gene:lrp5 / 568518 ZFINID:ZDB-GENE-050518-2 Length:1615 Species:Danio rerio


Alignment Length:467 Identity:159/467 - (34%)
Similarity:226/467 - (48%) Gaps:99/467 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   527 CSSKNGGCMHQCVNLEVG--YRCECHDGYKLGADQHTCVDIDECETPGICSQVCVNEIGAFKCEC 589
            ||.:||||.|.|:...:.  |.|.|..|.||..|..||       .|| ..||            
Zfish   304 CSERNGGCSHLCLLSPIPPFYSCACPTGVKLKEDGKTC-------RPG-AEQV------------ 348

  Fly   590 EAGYMRLLKNHTRCKASEGHASLLLARRHDIRKIALDRPEMTSI---VNSTKAATALDFVFRTGM 651
                                  ||||||.|:|:|:||.|:.|.|   ||..:.|.|:|:....|.
Zfish   349 ----------------------LLLARRTDLRRISLDLPDFTDIVLQVNDIRHAIAIDYDPVEGY 391

  Fly   652 IFWSDVATQSIYKAPIDEGNDRTVVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSMG 716
            ::|:|...::|.:|.|| |:|...::|......||:||||:..::|:|||....||:|...|:..
Zfish   392 VYWTDDELRAIRRARID-GSDAQTLITNEINHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR 455

  Fly   717 KVLVKDSLDIPRSIALDPIEGWMYWSDWGASPRIERAGMDGTHRTAIITYDVKWPNGITLDLVQK 781
            :||:.::||.||:|.||||.|:|||:|||..|:||||.:|||.|..::...:.||||:.:|.:..
Zfish   456 RVLISENLDEPRAIVLDPINGYMYWTDWGELPKIERANLDGTDRVVLLNTSLGWPNGLAIDYIAG 520

  Fly   782 RLYWVDGKLNTISSSNYDGSQRHQVLYSGEYLRHPFSITTFEDYVYWTDWDKQAVFKANKFNGM- 845
            :|||.|.|.:.|...|.||:.|..:|  .:.|.|.|..|...:|:|||||.::::.:.:..|.. 
Zfish   521 KLYWGDAKTDKIEVINVDGTNRMTIL--EDKLPHIFGFTLLGEYIYWTDWQRRSIERVHIANSTR 583

  Fly   846 --------DVEPVTATHMLEHPMVVHVYHPYRQPDGVNHCQSVNGHCSHLCLPAPRINERSPRIS 902
                    |:..:.||.::|             .:|.|.|...||.|||||...|:      .:|
Zfish   584 EVIVEQLPDLMGLKATKVME-------------AEGTNGCAENNGGCSHLCFHRPQ------GLS 629

  Fly   903 CACPTGLKLMPDGLMCV--EDLGIPTVRPTAPMHRTIEQSSNST-TKLPQDGYSE---------- 954
            ||||.||:|:.|...||  |...:.|.|...   |:|...:||. ..:|..|..|          
Zfish   630 CACPMGLELLSDLRTCVVPEAFLLFTNRADI---RSISLGTNSNDVPIPLTGVKEASALDFDVLE 691

  Fly   955 -----TPVETKT 961
                 |.|.|||
Zfish   692 NRIYWTDVSTKT 703

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LpR2NP_001097928.1 LDLa 193..224 CDD:197566
LDLa 235..267 CDD:197566
LDLa 277..313 CDD:238060
LDLa 356..388 CDD:197566
LDLa 400..432 CDD:197566
LDLa 442..476 CDD:238060
LDLa 484..517 CDD:197566
FXa_inhibition 527..562 CDD:291342 15/36 (42%)
EGF_CA 564..594 CDD:214542 4/29 (14%)
LY 675..715 CDD:214531 15/39 (38%)
LY 717..760 CDD:214531 26/42 (62%)
LY 763..803 CDD:214531 14/39 (36%)
FXa_inhibition 877..918 CDD:291342 18/40 (45%)
lrp5XP_009296098.1 LY 105..147 CDD:214531
Ldl_recept_b 168..208 CDD:278487
LY 192..234 CDD:214531
LY 235..269 CDD:214531
FXa_inhibition 304..341 CDD:291342 15/36 (42%)
Ldl_recept_b 390..429 CDD:278487 13/39 (33%)
LY 413..455 CDD:214531 15/41 (37%)
LY 456..499 CDD:214531 26/42 (62%)
LY 501..542 CDD:214531 14/40 (35%)
LY 544..583 CDD:214531 12/40 (30%)
FXa_inhibition 610..645 CDD:291342 18/40 (45%)
LY 674..714 CDD:214531 8/30 (27%)
LY 717..757 CDD:214531
LY 758..800 CDD:214531
LY 802..843 CDD:214531
LY 845..884 CDD:214531
FXa_inhibition 911..946 CDD:291342
LY 974..1013 CDD:214531
LY 1106..1148 CDD:214531
FXa_inhibition 1219..1255 CDD:291342
LDLa 1261..1297 CDD:238060
LDLa 1300..1334 CDD:238060
LDLa 1338..1372 CDD:238060
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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