DRSC/TRiP Functional Genomics Resources

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Protein Alignment LpR2 and lrp1ab

DIOPT Version :9

Sequence 1:NP_001097928.1 Gene:LpR2 / 43105 FlyBaseID:FBgn0051092 Length:1064 Species:Drosophila melanogaster
Sequence 2:XP_021325646.1 Gene:lrp1ab / 565797 ZFINID:ZDB-GENE-030131-7126 Length:4562 Species:Danio rerio


Alignment Length:827 Identity:315/827 - (38%)
Similarity:433/827 - (52%) Gaps:111/827 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   180 GTPLDISLGLSN--YC----DEKQFQCS------------TGECIPIRFVCDGSSDCPDHSDERL 226
            |..:|.||...:  :|    ||||..|:            .|.||.....||.:.||.|.|||. 
Zfish  2536 GDCIDYSLTCDSLAHCKDKSDEKQAYCANRMCKKGYRRCINGRCIKHSSWCDSTDDCGDGSDEL- 2599

  Fly   227 EECKFTESTCSQEQFRCGNGKCIPR---------------------------------------- 251
             .|..|  .||..:|:|.:|.||..                                        
Zfish  2600 -PCNMT--LCSAAEFQCKDGSCITNSSRCNQVVDCEDASDEMNCSPTDCSSYYLLGVKGMTFERC 2661

  Fly   252 ---------RWVCDRENDCADGSDE-STSQCRSHTCSPEEFACKSGEGECIPLSWMCDQNKDCRD 306
                     .|.||..|||.|.||| :..:.|...||...|||.|  |.|||:||.||:..||.|
Zfish  2662 EFTTLCFAPSWRCDGSNDCGDFSDERNCPEKRQQKCSENNFACPS--GRCIPMSWTCDKENDCED 2724

  Fly   307 GSDEAQCNR---TCRSDEFTCGNGRCIQNRFKCDDDDDCGDGSDE-KNCGEKAK-CGSNFFACK- 365
            |:|||.|.:   .|.|::|.|||.|||...:.||..||||||:|| ..|  ||| ||.:.|.|. 
Zfish  2725 GADEAHCEKFFQFCASNQFECGNHRCIFKTWVCDGTDDCGDGTDEDSRC--KAKTCGPDSFQCPG 2787

  Fly   366 SGPCIPNQWVCDGDSDCRNGEDEMQNCTVSLLNFCQAGEFQCSDRITCLHKSWVCDGEADCPDGE 430
            |..||..:||||||.||.:|.||...........|...||||.:. .|:.|:::||.:.||.||.
Zfish  2788 SHVCILQRWVCDGDKDCPDGGDEGLKAGCVFNKTCDDTEFQCQNS-QCIPKNFMCDHDIDCRDGS 2851

  Fly   431 DESQSNCLKVSCRPDQFQCNDQSCI-AGHLTCNGKRDCADGSDE----IMCDISATPRTCNATTE 490
            ||| ..|...:|.|:.|.|.:..|: ..:..|:|:.||.|.|||    :.|  :.|...|| .|.
Zfish  2852 DES-PECEYPTCGPNDFHCANGQCLKQKNWACDGEFDCRDQSDEAPKNLQC--TDTESRCN-DTA 2912

  Fly   491 FDCGGGLCIPNAKVCNRRKDCPNGEDEPAGKCGINEC-SSKNGGCMHQCVNLEVGYRCECHDGYK 554
            |.|..|.|:....:|:...||.:|.||  ..|.:||| :||..||...|.:|::|::|.|:.|::
Zfish  2913 FLCSSGKCVNETLLCDNNNDCGDGSDE--NNCFVNECLNSKLSGCSQLCEDLKIGFKCRCNAGFR 2975

  Fly   555 LGADQHTCVDIDECETPGICSQVCVNEIGAFKCECEAGYMRLLKNHTRCKA-SEGHASLLLARRH 618
            |..|..||||:|||.|...|||.|:|..|:|.|.|..|::....:||.||: :|....|:.|.|:
Zfish  2976 LKQDGKTCVDLDECSTVYPCSQRCINTHGSFHCLCVDGFVPRPDDHTSCKSTAEEEPFLIFANRY 3040

  Fly   619 DIRKIALDRPEMTSIVNSTKAATALDFVFRTGMIFWSDVATQS--IYKAPIDEGNDRTVVLTKSS 681
            .:||:.||....|.|......|.|||:.:...||:|:||.||.  |.:..|:..|  ..||.::|
Zfish  3041 YLRKLNLDGSNYTLIKQGLNNAVALDYHYAEQMIYWTDVTTQGSMIRRMHINGSN--VQVLHRTS 3103

  Fly   682 VTS-DGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWG 745
            ::: |||||||:..::|:.|..:.|||::...|:...|||...|..||::|:|...|::||||||
Zfish  3104 LSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRSVLVNSGLREPRAVAVDVRNGYLYWSDWG 3168

  Fly   746 ASPRIERAGMDGTHRTAIITYDVKWPNGITLDLVQKRLYWVDGKLNTISSSNYDGSQRHQVLYSG 810
            ..|.|.|.|||||.|..||...:.||||:|||.:..|:||.|.:.:.|:.::.|||.||.||  .
Zfish  3169 DVPHIGRIGMDGTDRQIIIQDKITWPNGLTLDFINDRIYWADAREDYIAFASLDGSNRHTVL--N 3231

  Fly   811 EYLRHPFSITTFEDYVYWTDWDKQAVFKANKFNGMDVEPVTATHMLEHPMVVHVYHPYRQPDGVN 875
            ..:.|.|::|.||:::|||||:.:::.:|:|..|.:...:.:|  |..||.:|::||.|||:...
Zfish  3232 HDIPHIFAMTLFEEFIYWTDWETKSINRAHKTLGTNKTLLIST--LHRPMDIHIFHPSRQPEVSG 3294

  Fly   876 H-CQSVNGHCSHLCLPAPRINERSPRISCACPTGLKLMPDGLMCVED 921
            | ||..||.||:|||.:|     .....|||||...|..||..|:.:
Zfish  3295 HPCQEDNGGCSNLCLLSP-----GGGYKCACPTNFYLAADGKQCLSN 3336

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LpR2NP_001097928.1 LDLa 193..224 CDD:197566 15/46 (33%)
LDLa 235..267 CDD:197566 15/80 (19%)
LDLa 277..313 CDD:238060 21/35 (60%)
LDLa 356..388 CDD:197566 17/33 (52%)
LDLa 400..432 CDD:197566 13/31 (42%)
LDLa 442..476 CDD:238060 13/38 (34%)
LDLa 484..517 CDD:197566 11/32 (34%)
FXa_inhibition 527..562 CDD:291342 13/35 (37%)
EGF_CA 564..594 CDD:214542 15/29 (52%)
LY 675..715 CDD:214531 16/40 (40%)
LY 717..760 CDD:214531 23/42 (55%)
LY 763..803 CDD:214531 17/39 (44%)
FXa_inhibition 877..918 CDD:291342 18/40 (45%)
lrp1abXP_021325646.1 LDLa 36..69 CDD:197566
LDLa 81..114 CDD:197566
FXa_inhibition 170..198 CDD:317114
NHL <292..479 CDD:302697
NHL repeat 292..325 CDD:271320
LY 323..365 CDD:214531
NHL repeat 332..368 CDD:271320
LY 368..408 CDD:214531
NHL repeat 373..413 CDD:271320
NHL repeat 421..467 CDD:271320
FXa_inhibition 494..526 CDD:317114
LY 558..600 CDD:214531
LY 602..640 CDD:214531
LY 647..695 CDD:214531
LY <707..740 CDD:214531
FXa_inhibition 811..846 CDD:317114
LDLa 857..889 CDD:197566
LDLa 899..932 CDD:238060
LDLa 940..971 CDD:238060
LDLa 982..1015 CDD:238060
LDLa 1019..1052 CDD:238060
LDLa 1066..1101 CDD:238060
LDLa 1110..1144 CDD:238060
LDLa 1149..1185 CDD:238060
FXa_inhibition 1188..1224 CDD:317114
LY 1339..1381 CDD:214531
LY 1383..1426 CDD:214531
LY 1437..1470 CDD:214531
LY 1479..1515 CDD:214531
LY 1616..1652 CDD:214531
LY 1653..1696 CDD:214531
LY 1700..1739 CDD:214531
LY 1739..1780 CDD:214531
FXa_inhibition 1853..1889 CDD:317114
LY 1919..1959 CDD:214531
LY 1962..2002 CDD:214531
LY 2003..2046 CDD:214531
LY 2048..2090 CDD:214531
FXa_inhibition 2162..2197 CDD:317114
SGL 2236..2464 CDD:331563
Ldl_recept_b 2346..2387 CDD:278487
LY 2372..2413 CDD:214531
FXa_inhibition 2483..2518 CDD:317114
LDLa 2523..2559 CDD:294076 7/22 (32%)
LDLa 2567..2601 CDD:238060 11/35 (31%)
LDLa 2606..2640 CDD:238060 7/33 (21%)
LDLa <2667..2689 CDD:238060 10/21 (48%)
LDLa 2697..2731 CDD:238060 21/35 (60%)
LDLa 2738..2769 CDD:197566 17/30 (57%)
LDLa 2777..2810 CDD:197566 16/32 (50%)
LDLa 2821..2853 CDD:197566 13/32 (41%)
Ldl_recept_a 2861..2895 CDD:278486 12/33 (36%)
LDLa 2908..2942 CDD:238060 13/36 (36%)
cEGF 2965..2988 CDD:315355 10/22 (45%)
EGF_CA 2985..3019 CDD:214542 15/33 (45%)
LY 3052..3096 CDD:214531 16/45 (36%)
LY 3097..3139 CDD:214531 16/41 (39%)
LY 3141..3183 CDD:214531 23/41 (56%)
LY 3184..3226 CDD:214531 17/41 (41%)
LY 3227..3267 CDD:214531 16/41 (39%)
FXa_inhibition 3297..3333 CDD:317114 18/40 (45%)
LDLa 3337..3368 CDD:238060 315/827 (38%)
LDLa 3377..3411 CDD:238060
LDLa 3416..3451 CDD:238060
LDLa 3455..3488 CDD:197566
LDLa 3496..3529 CDD:197566
LDLa 3539..3573 CDD:238060
LDLa 3578..3612 CDD:238060
LDLa 3616..3650 CDD:238060
LDLa 3658..3690 CDD:238060
LDLa 3699..3735 CDD:238060
LDLa 3741..3776 CDD:238060
EGF_CA 3825..3855 CDD:214542
LY 3963..3999 CDD:214531
Ldl_recept_b 4020..4060 CDD:278487
LY 4044..4085 CDD:214531
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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