Protein Alignment LpR2 and lrp1bb

DIOPT Version :10

• Sequence 1: NP_001097928.1
• Gene: LpR2 / 43105
• FlyBaseID: FBgn0051092
• Length: 1064
• Species: Drosophila melanogaster
• Sequence 2: XP_073769005.1
• Gene: lrp1bb / 559293
• ZFINID: ZDB-GENE-070912-401
• Length: 4666
• Species: Danio rerio
• Alignment Length: 753
• Identity: 285/753 - (37%)
• Similarity: 403/753 - (53%)
• Gaps: 53/753 - (7%)

  Fly   193 CDEKQFQCSTGECIPIRFVCDGSSDCPDHSDERLEECKFTESTCSQEQFRCGNGKCIPRRWVCDR 257
            |...:|||..|.||.:.::|||..||.|.|||....|  :..:|..:||:|.:.:|||:||:||.
Zfish   879 CRSDEFQCRNGRCIRVNWICDGDDDCLDGSDEEPHIC--SNHSCPIDQFKCPSNRCIPKRWLCDG 941

  Fly   258 ENDCADGSDESTSQCRSHTCSPEEFACKSGEGECIPLSWMCDQNKDCRDGSDEA-QCN-RTCRS- 319
            .:||.|..|||...|.:..|...:|.|  |.|.|:|.:|.|||:.||.|.|||: .|: .||.:
Zfish   942 ADDCGDNEDESNKTCSAQPCRAGQFTC--GNGRCVPEAWRCDQDDDCGDMSDESTSCSFPTCEAL 1004

  Fly   320 DEFTCGNGRCIQNRFKCDDDDDCGDGSDEKNCGEKAKCGSNFFACKSGPCIPNQWVCDGDSDCRN 384
            .:|:|.|||||..::.||.||||||.|||..|..  .|.:..:.|.||.|||:.|.||||:||.:
Zfish  1005 SQFSCANGRCISMKWHCDSDDDCGDNSDEAGCVH--FCANGQYKCTSGRCIPDHWACDGDNDCGD 1067

  Fly   385 GEDEMQNCT--------VSLLNFCQAGEFQCSDRITCLHKSWVCDGEADCPDGEDESQSNCLKVS 441
            ..||...|.        |.    |.|.||.|....||:.:.|.|||:.||.||.||:....:|..
Zfish  1068 FSDENVTCAGVAPALPPVE----CSAEEFHCRADGTCIPERWRCDGDKDCEDGSDETNCKGVKRM 1128

  Fly   442 CRPD-QFQCNDQ-SCIAGHLTCNGKRDCADGSDEIMCDISATPRTCNATTEFDCG--GGLCIPNA 502
            |.|. :|.|... .||:....|:|..||.|.|||..|..|    .|...|: .|.  ..:|:|..
Zfish  1129 CDPQAKFTCKTSGKCISKSWVCDGDDDCEDRSDEESCVSS----ICKPPTQ-PCANDSSICLPQN 1188

  Fly   503 KVCNRRKDCPNGEDEPAGKCGINECSSKNGGCMHQC-VNLEVGYRCECHDGYKLGADQHTCVDID 566
            |:|:.|.||.:..|| ...|  ..|...||||.||| |....|..|.|..|..||:|..||..:|
Zfish  1189 KICDGRMDCADRSDE-GPFC--ERCLQGNGGCSHQCSVIPSKGVVCSCPAGLHLGSDNRTCEAVD 1250

  Fly   567 ECETPGICSQVCVNEIGAFKCECEAGYMRLLKNHTRCKASEG-HASLLLARRHDIRKIALDRPEM 630
            .|.....|||:|.......||.|..|: ||..:...|.:::. .|.::.:.||:||:|.|.:.:.
Zfish  1251 YCSAHLKCSQICEQHKTTVKCSCYPGW-RLDADGESCHSTDPFEAFVIFSIRHEIRRIDLHKHDY 1314

  Fly   631 TSIVNSTKAATALDFVFRTGMIFWSDVATQSIYKAPIDEGNDRT---VVLTKSSVTSDGLAVDWI 692
            :.:|...:...||||.|...:::|:||....||:..:.|....|   ||:.....|.:|||||||
Zfish  1315 SLLVPGLRNTIALDFHFSHSLLYWTDVVEDKIYRGKLSETGGVTGVEVVIQHGLATPEGLAVDWI 1379

  Fly   693 YNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGAS-PRIERAGMD 756
            ..::|:.|::...||:....|.|...|:...::.||::|:||.:|.::|:||.|: ||||...|.
Zfish  1380 AGNLYWIDSNLDQIEVAKLNGEMRTTLIAGGMEHPRALAVDPGQGILFWTDWDATFPRIEATSMS 1444

  Fly   757 GTHRTAIITYDVK---WPNGITLDLVQKRLYWVDGKLNTISSSNYDGSQRHQVLYSGEYLRHPFS 818
            |:.| .::..|::   ||||:|||..::|:.|.|.:.:.|.|:.||||...::|...|||.|||:
Zfish  1445 GSGR-HVVYKDMEIGAWPNGLTLDHQERRIVWTDARSDAIYSALYDGSGVIEILRGHEYLSHPFA 1508

  Fly   819 ITTFEDYVYWTDWDKQAVFKANKFNGMDVEPVTATHMLEHPMVVHVYHPYRQPDGVNHCQSVNGH 883
            ::.|...||||||....:.:|||:.|.:|..:..|.  ..|..:.:|||.|||...|.|:..:|.
Zfish  1509 VSLFGGGVYWTDWRTNTLARANKWTGHNVTVIQKTS--AQPFDLEIYHPSRQPQASNPCEGNDGR 1571

  Fly   884 --CSHLCLPAPRINERSPRISCACPTGLKLMPDGLMCV 919
              ||||||     .:.:...||:||..:||..:...||
Zfish  1572 GPCSHLCL-----IDYNRTASCSCPHLMKLSLNNRSCV 1604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LpR2	NP_001097928.1	LDLa	193..224	CDD:197566	14/30 (47%)
		LDLa	235..267	CDD:197566	14/31 (45%)
		LDLa	277..313	CDD:238060	17/36 (47%)
		LDLa	356..388	CDD:197566	14/31 (45%)
		LDLa	400..432	CDD:197566	15/31 (48%)
		LDLa	442..476	CDD:238060	14/35 (40%)
		LDLa	484..517	CDD:197566	10/34 (29%)
		FXa_inhibition	527..562	CDD:464251	16/35 (46%)
		EGF_CA	564..594	CDD:214542	10/29 (34%)
		LY	675..715	CDD:214531	15/39 (38%)
		LY	717..760	CDD:214531	17/43 (40%)
		LY	763..803	CDD:214531	17/42 (40%)
		Ldl_recept_b	782..828	CDD:459654	18/45 (40%)
		Ldl_recept_b	824..866	CDD:459654	13/41 (32%)
		FXa_inhibition	877..918	CDD:464251	14/42 (33%)
lrp1bb	XP_073769005.1	None