DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LpR2 and sorl1

DIOPT Version :9

Sequence 1:	NP_001097928.1	Gene:	LpR2 / 43105	FlyBaseID:	FBgn0051092	Length:	1064	Species:	Drosophila melanogaster
Sequence 2:	XP_005157607.1	Gene:	sorl1 / 497306	ZFINID:	ZDB-GENE-050208-22	Length:	2213	Species:	Danio rerio

Alignment Length:	794	Identity:	228/794 - (28%)
Similarity:	303/794 - (38%)	Gaps:	217/794 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 CDEKQFQCSTGECIPIRFVCDGSSDCPDHSDERLEECKFTESTCSQE-QFRC-GNGKCIPRRWVC 255
            |...|.:|:.|:||...:.||..:||.|.|||  :||..|  :|... |||| .:|.|||..:.|
Zfish  1079 CLPNQHRCANGKCISSIWKCDSDNDCGDMSDE--QECPTT--SCDPSVQFRCVASGSCIPLAFKC 1139

  Fly   256 DRENDCADGSDESTSQCRSHTCSPEEFACKSGEGECIPLSWMCDQNKDCRDGSDEAQC---NRTC 317
            |.|:||.|.|||  ..|.||.|.|.||.|  ..|.||..:|.||.:.||||.||||.|   :.||
Zfish  1140 DHEDDCGDNSDE--EHCESHKCGPGEFTC--ARGACIRDAWRCDGDNDCRDWSDEANCTVGHHTC 1200

  Fly   318 RSDEFTCGNGRCIQNRFKCDDDDDCGDGSDE--KNCGEKAKCGSNFFACKSGPCIPNQWVCDGDS 380
            .|..|.|..|.||..|:.||.||||.|||||  ..|| :.||  |.|.|.:|.|:|....|:|..
Zfish  1201 ESSSFQCHTGHCIPQRWVCDGDDDCQDGSDEDPTQCG-RQKC--NGFLCSNGTCLPASAHCNGVE 1262

  Fly   381 DCRNGEDEMQNCTVSLLNFCQAGEFQCSDRITCLHKSWVCDGEADCPDGEDE------------- 432
            ||..|.|| |||.....::.   ||.|.:|..||.:|.||||...|.||.||
Zfish  1263 DCPGGADE-QNCGPLCAHYM---EFVCRNRAQCLFQSLVCDGTRHCADGSDEDPIYAGCSTSVEF 1323

  Fly   433 ---------------------------------SQSNCLKVSCRPD-----QFQCNDQSCIAGHL 459
                                             .::||...:..|.     :|:|.:..|:....
Zfish  1324 EKTCDGYNFQCTNGMCVTLEWKCDGMDDCGDYSDEANCASPTEEPGCTSYFRFECKNGRCVPAWW 1388

  Fly   460 TCNGKRDCADGSDEIMCD-------ISATPRTCNATTEFDCGGGLCIPNAKVCNRRKDCPNGEDE 517
            .|:|:.||.|.|||..|.       .:..|.|| |...|.||.|.||.:..||:...|||:..||
Zfish  1389 KCDGENDCGDWSDESQCSGGEALHTPAPGPATC-APNRFRCGSGACIVDTWVCDGYADCPDSSDE 1452

  Fly   518 PAGKCGINECSSKNGGCMHQCVNLEVGYRCECHDGYKLGADQHTCV-------DIDECETPGICS 575
             ||      |.:..|. :.....|....||.        .||..||       |...|:....|.
Zfish  1453 -AG------CPTVKGS-VTSVTTLPPSGRCT--------KDQFLCVKPPACISDWKRCDGHSHCL 1501

  Fly   576 QVCVNEIGAFKCECEAGYMRLLKNHTRCKASEGHASLLLARRHD--------------------- 619
            .      |:.:..|......|..|.|||  ::|.|.||.:.|.|
Zfish  1502 D------GSDEANCPTHGPLLCANGTRC--ADGEACLLNSERCDGFIDCSDRSDEHNCTDEQQVY 1558

  Fly   620 -------------IRKIALDRPEMTSIVNSTKAATALDFVFR-TGMIFWSDVATQSIYKAPIDEG 670
                         ..|:...||:     |...::.:....|| .|:..|:.:.|.|
Zfish  1559 KVQNLQWTANFSGAVKLTWTRPK-----NMPTSSCSFVIYFRPVGVQQWTSIDTNS--------- 1609

  Fly   671 NDRTVVLTKSSVTSDGLAVDWIYNHVYFTD----THKCTIELTNFEGSMGKVLVKDSL-DIPRSI 730
            |..:.|||.       |..|..||....|.    .|:....||        :...:.| |.|:|:
Zfish  1610 NKGSAVLTV-------LMPDTTYNVKVQTQCLSKQHRTNEYLT--------LRTPEGLPDPPQSL 1659

  Fly   731 AL--DPIEGWMYWSDWGASPRIERAGMDGTH---RTAIITYDVKWPNGITLDLVQKRLYWVDGKL 790
            .|  |..:.......|  ||      .|.||   |..|:.|..|       |..:    |.
Zfish  1660 QLSCDKADDGTVLCSW--SP------PDKTHGHIREYIVEYSEK-------DSAE----WF---- 1701

  Fly   791 NTISSSNYDGSQRHQVLYSGEYLRHPFSITTFEDYVYWTDWDKQAVFKANKFNGMDVEPVTATHM 855
             ::||::.:...::  |......|...:..|......||:.......||     :....||.|.:
Zfish  1702 -SLSSTSTNAEVKN--LQPSSLYRFRVAAVTSRGVGNWTEIKSIIPQKA-----LSPPKVTITSI 1758

  Fly   856 LEHPMVVHVYHPYR 869
            .|..|.:.:.:.|:
Zfish  1759 TEDSMSLSISNDYK 1772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR2	NP_001097928.1	LDLa	193..224	CDD:197566	12/30 (40%)
		LDLa	235..267	CDD:197566	16/33 (48%)
		LDLa	277..313	CDD:238060	19/35 (54%)
		LDLa	356..388	CDD:197566	13/31 (42%)
		LDLa	400..432	CDD:197566	14/31 (45%)
		LDLa	442..476	CDD:238060	12/38 (32%)
		LDLa	484..517	CDD:197566	14/32 (44%)
		FXa_inhibition	527..562	CDD:291342	7/34 (21%)
		EGF_CA	564..594	CDD:214542	5/29 (17%)
		LY	675..715	CDD:214531	11/43 (26%)
		LY	717..760	CDD:214531	12/48 (25%)
		LY	763..803	CDD:214531	7/39 (18%)
		FXa_inhibition	877..918	CDD:291342
sorl1	XP_005157607.1	VPS10	130..754	CDD:214740
		Sortilin_C	589..754	CDD:292523
		LY	781..822	CDD:214531
		LY	825..864	CDD:214531
		LY	868..912	CDD:214531
		LY	916..954	CDD:214531
		LDLa	1079..1113	CDD:238060	14/35 (40%)
		LDLa	1118..1154	CDD:238060	18/37 (49%)
		LDLa	1159..1193	CDD:238060	19/35 (54%)
		LDLa	1242..1273	CDD:238060	14/31 (45%)
		LDLa	1282..1310	CDD:197566	14/27 (52%)
		LDLa	1327..1361	CDD:238060	0/33 (0%)
		LDLa	1376..1405	CDD:238060	11/28 (39%)
		LDLa	1421..1455	CDD:238060	17/41 (41%)
		LDLa	1474..1509	CDD:238060	9/48 (19%)
		LDLa	1522..1551	CDD:238060	8/30 (27%)
		FN3	1559..>1630	CDD:238020	18/91 (20%)
		FN3	1653..1743	CDD:238020	24/115 (21%)
		FN3	1750..1827	CDD:238020	6/23 (26%)
		FN3	1931..2007	CDD:238020
		FN3	2022..2097	CDD:214495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810