DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LpR2 and LRP5

DIOPT Version :9

Sequence 1:	NP_001097928.1	Gene:	LpR2 / 43105	FlyBaseID:	FBgn0051092	Length:	1064	Species:	Drosophila melanogaster
Sequence 2:	XP_011543331.1	Gene:	LRP5 / 4041	HGNCID:	6697	Length:	1662	Species:	Homo sapiens

Alignment Length:	464	Identity:	147/464 - (31%)
Similarity:	220/464 - (47%)	Gaps:	88/464 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   527 CSSKNGGCMHQCV--NLEVGYRCECHDGYKLGADQHTCVDIDECETPGICSQVCVNEIGAFKCEC 589
            |...||||.|.|:  ..|..|.|.|..|.:|..:..|                           |
Human   308 CEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRT---------------------------C 345

  Fly   590 EAGYMRLLKNHTRCKASEGHASLLLARRHDIRKIALDRPEMTSI---VNSTKAATALDFVFRTGM 651
            :||            |.|   .||||||.|:|:|:||.|:.|.|   |:..:.|.|:|:....|.
Human   346 KAG------------AEE---VLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGY 395

  Fly   652 IFWSDVATQSIYKAPIDEGNDRTVVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSMG 716
            ::|:|...::|.:|.:|....:|:|.|:.: ..||:||||:..::|:|||....||:|...|:..
Human   396 VYWTDDEVRAIRRAYLDGSGAQTLVNTEIN-DPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR 459

  Fly   717 KVLVKDSLDIPRSIALDPIEGWMYWSDWGASPRIERAGMDGTHRTAIITYDVKWPNGITLDLVQK 781
            |:||.:.||.||:|||.|:.|.|||:|||.:|:||.|.:||..|..::...:.||||:.|||.:.
Human   460 KILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEG 524

  Fly   782 RLYWVDGKLNTISSSNYDGSQRHQVLYSGEYLRHPFSITTFEDYVYWTDWDKQAVFKANKFNG-- 844
            :|||.|.|.:.|...|.||::|..:|  .:.|.|.|..|...|::|||||.::::.:.:|...
Human   525 KLYWGDAKTDKIEVINVDGTKRRTLL--EDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASR 587

  Fly   845 ----------MDVEPVTATHMLEHPMVVHVYHPYRQPDGVNHCQSVNGHCSHLCLPAPRINERSP 899
                      |.::.|....::                |.|.|...||.|||||...|....
Human   588 DVIIDQLPDLMGLKAVNVAKVV----------------GTNPCADRNGGCSHLCFFTPHATR--- 633

  Fly   900 RISCACPTGLKLMPDGLMCVEDLGIPTVRPTAPMHRTIEQSSNSTTKLPQDGYSE-TPVETKTGN 963
               |.||.||:|:.|...|:...........|.:||...:::|:...:|..|..| :.::....|
Human   634 ---CGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDFDVSN 695

  Fly   964 NR---TDTS 969
            |.   ||.|
Human   696 NHIYWTDVS 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR2	NP_001097928.1	LDLa	193..224	CDD:197566
		LDLa	235..267	CDD:197566
		LDLa	277..313	CDD:238060
		LDLa	356..388	CDD:197566
		LDLa	400..432	CDD:197566
		LDLa	442..476	CDD:238060
		LDLa	484..517	CDD:197566
		FXa_inhibition	527..562	CDD:291342	13/36 (36%)
		EGF_CA	564..594	CDD:214542	3/29 (10%)
		LY	675..715	CDD:214531	16/39 (41%)
		LY	717..760	CDD:214531	24/42 (57%)
		LY	763..803	CDD:214531	16/39 (41%)
		FXa_inhibition	877..918	CDD:291342	16/40 (40%)
LRP5	XP_011543331.1	NHL	<46..>178	CDD:302697
		NHL repeat	74..113	CDD:271320
		LY	111..151	CDD:214531
		NHL repeat	116..157	CDD:271320
		Ldl_recept_b	172..212	CDD:278487
		LY	196..238	CDD:214531
		FXa_inhibition	308..345	CDD:291342	14/63 (22%)
		LY	375..415	CDD:214531	10/39 (26%)
		LY	417..459	CDD:214531	17/42 (40%)
		LY	460..503	CDD:214531	24/42 (57%)
		LY	504..546	CDD:214531	16/41 (39%)
		LY	547..580	CDD:214531	11/34 (32%)
		FXa_inhibition	614..649	CDD:291342	16/40 (40%)
		NHL	694..887	CDD:302697	5/11 (45%)
		LY	719..761	CDD:214531
		NHL repeat	729..765	CDD:271320
		NHL repeat	772..811	CDD:271320
		NHL repeat	856..880	CDD:271320
		FXa_inhibition	915..950	CDD:291342
		LY	979..1018	CDD:214531
		LY	1069..1112	CDD:214531
		LY	1113..1155	CDD:214531
		FXa_inhibition	1226..1262	CDD:291342
		Ldl_recept_a	1267..1304	CDD:278486
		LDLa	1307..1341	CDD:238060
		LDLa	1345..1379	CDD:238060
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810