| Sequence 1: | NP_001097928.1 | Gene: | LpR2 / 43105 | FlyBaseID: | FBgn0051092 | Length: | 1064 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_002327.2 | Gene: | LRP6 / 4040 | HGNCID: | 6698 | Length: | 1613 | Species: | Homo sapiens |
| Alignment Length: | 309 | Identity: | 132/309 - (42%) |
|---|---|---|---|
| Similarity: | 187/309 - (60%) | Gaps: | 10/309 - (3%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 612 LLLARRHDIRKI--ALDRPEMTSIVNSTKAATALDFVFRTGMIFWSDVATQSIYKAPIDEGNDRT 674
Fly 675 VVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWM 739
Fly 740 YWSDWGASPRIERAGMDGTHRTAIITYDVKWPNGITLDLVQKRLYWVDGKLNTISSSNYDGSQRH 804
Fly 805 QVLYSGEYLRHPFSITTFEDYVYWTDWDKQAVFKANKFNGMDVEPVTATHMLEHPMVVHVYHPYR 869
Fly 870 QPDGVNHCQSVNGHCSHLCLPAPRINERSPRISCACPTGLKLMPDGLMC 918 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| LpR2 | NP_001097928.1 | LDLa | 193..224 | CDD:197566 | |
| LDLa | 235..267 | CDD:197566 | |||
| LDLa | 277..313 | CDD:238060 | |||
| LDLa | 356..388 | CDD:197566 | |||
| LDLa | 400..432 | CDD:197566 | |||
| LDLa | 442..476 | CDD:238060 | |||
| LDLa | 484..517 | CDD:197566 | |||
| FXa_inhibition | 527..562 | CDD:291342 | |||
| EGF_CA | 564..594 | CDD:214542 | |||
| LY | 675..715 | CDD:214531 | 14/39 (36%) | ||
| LY | 717..760 | CDD:214531 | 28/42 (67%) | ||
| LY | 763..803 | CDD:214531 | 21/39 (54%) | ||
| FXa_inhibition | 877..918 | CDD:291342 | 20/40 (50%) | ||
| LRP6 | NP_002327.2 | Beta-propeller 1 | 20..275 | 107/255 (42%) | |
| NHL | 55..272 | CDD:302697 | 97/220 (44%) | ||
| NHL repeat | 55..93 | CDD:271320 | 13/37 (35%) | ||
| LY | 89..127 | CDD:214531 | 13/37 (35%) | ||
| NHL repeat | 97..132 | CDD:271320 | 15/34 (44%) | ||
| NHL repeat | 140..176 | CDD:271320 | 24/35 (69%) | ||
| Ldl_recept_b | 150..190 | CDD:278487 | 24/39 (62%) | ||
| LY | 175..216 | CDD:214531 | 21/40 (53%) | ||
| NHL repeat | 181..217 | CDD:271320 | 19/35 (54%) | ||
| NHL repeat | 226..253 | CDD:271320 | 13/26 (50%) | ||
| LDL-receptor class B 5 | 237..276 | 11/40 (28%) | |||
| FXa_inhibition | 286..323 | CDD:291342 | 20/40 (50%) | ||
| Beta-propeller 2 | 328..589 | ||||
| LY | 353..393 | CDD:214531 | |||
| LY | 397..437 | CDD:214531 | |||
| LY | 438..481 | CDD:214531 | |||
| LY | 483..524 | CDD:214531 | |||
| LY | 525..558 | CDD:214531 | |||
| FXa_inhibition | 592..627 | CDD:291342 | |||
| Beta-propeller 3 | 631..890 | ||||
| LY | 656..694 | CDD:214531 | |||
| LY | 697..739 | CDD:214531 | |||
| LY | 740..783 | CDD:214531 | |||
| LY | 783..825 | CDD:214531 | |||
| LY | 827..866 | CDD:214531 | |||
| FXa_inhibition | 893..929 | CDD:291342 | |||
| Beta-propeller 4 | 933..1202 | ||||
| LY | 958..998 | CDD:214531 | |||
| Ldl_recept_b | 1069..1110 | CDD:278487 | |||
| LY | 1094..1136 | CDD:214531 | |||
| FXa_inhibition | 1207..1243 | CDD:291342 | |||
| LDLa | 1249..1285 | CDD:238060 | |||
| LDLa | 1288..1322 | CDD:238060 | |||
| LDLa | 1326..1360 | CDD:238060 | |||
| PPPSP motif A | 1487..1493 | ||||
| PPPSP motif B | 1527..1534 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1556..1613 | ||||
| PPPSP motif C | 1568..1575 | ||||
| PPPSP motif D | 1588..1593 | ||||
| PPPSP motif E | 1603..1610 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG1215 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 2 | 1.810 | |||||