DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LpR2 and LRP3

DIOPT Version :9

Sequence 1:NP_001097928.1 Gene:LpR2 / 43105 FlyBaseID:FBgn0051092 Length:1064 Species:Drosophila melanogaster
Sequence 2:XP_005259002.1 Gene:LRP3 / 4037 HGNCID:6695 Length:785 Species:Homo sapiens


Alignment Length:439 Identity:116/439 - (26%)
Similarity:152/439 - (34%) Gaps:142/439 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   185 ISLGLSNYCDEKQFQCS-----TGECIPIR---FVCDGSSDCPD------------HSDE----- 224
            |::...|:..|:..|||     .|...|.|   |...||:..|.            |||.     
Human    84 ITISFRNFDVEESHQCSLDWLLLGPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQ 148

  Fly   225 ----RLE--ECKFTESTCSQEQFRCGNGKCIPRRWVCDRENDCADGSDESTSQCRSHTCSPEEFA 283
                ||.  ..|..:::|..::|||.||||:|..|.|:..::|.|||||  ..|.:....|....
Human   149 AQGFRLSYIRGKLGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDE--GNCSAPASEPPGSL 211

  Fly   284 CKSG--------EGECIPLSWMCDQNKDCRDGSDEAQC-NRTC------------RSDEFTCGNG 327
            |..|        ...|:|:...||..:||.||||||.| :..|            ..|.|....|
Human   212 CPGGTFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARG 276

  Fly   328 ----RC---------------IQNRFKCDDDDDCGDGSDEKNCGEK------------------- 354
                .|               ::.|...||.....:|..|:  |::                   
Human   277 PSDLHCTWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGER--GDRLLQTLSYRSNHRPVSLEAA 339

  Fly   355 ------------AKCGSNFFAC--KSGPCIPNQWVCDGDSDCRNGEDEMQNCTVSLLNFCQAGEF 405
                        ...|..|.|.  ..|.|:|.:..|...||...|....|.|            |
Human   340 QGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGC------------F 392

  Fly   406 QCSDRITCLHKSWVCDGEADCPDGEDESQSNCLKVSCRPDQFQCNDQS--CIAGHLTCNGKRDCA 468
            ....|         |||...|..|.||  ..|  .:|.|||:.|...|  |......||.::.|.
Human   393 SEPQR---------CDGWWHCASGRDE--QGC--PACPPDQYPCEGGSGLCYTPADRCNNQKSCP 444

  Fly   469 DGSDEIMCDISATPRTCNATTEFDCGGGLCIPNAKVCNRRKDCPNGEDE 517
            ||:||..| .|..|.|      |.||..|||.....|:.::||.:|.||
Human   445 DGADEKNC-FSCQPGT------FHCGTNLCIFETWRCDGQEDCQDGSDE 486

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LpR2NP_001097928.1 LDLa 193..224 CDD:197566 13/50 (26%)
LDLa 235..267 CDD:197566 15/31 (48%)
LDLa 277..313 CDD:238060 15/43 (35%)
LDLa 356..388 CDD:197566 10/33 (30%)
LDLa 400..432 CDD:197566 7/31 (23%)
LDLa 442..476 CDD:238060 14/35 (40%)
LDLa 484..517 CDD:197566 11/32 (34%)
FXa_inhibition 527..562 CDD:291342
EGF_CA 564..594 CDD:214542
LY 675..715 CDD:214531
LY 717..760 CDD:214531
LY 763..803 CDD:214531
FXa_inhibition 877..918 CDD:291342
LRP3XP_005259002.1 CUB 43..156 CDD:238001 18/71 (25%)
LDLa 166..200 CDD:238060 17/35 (49%)
LDLa 212..249 CDD:238060 14/36 (39%)
CUB 254..364 CDD:238001 14/111 (13%)
LDLa 416..452 CDD:238060 14/35 (40%)
LDLa 455..489 CDD:238060 14/38 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.