DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LpR2 and LRP2

DIOPT Version :9

Sequence 1:	NP_001097928.1	Gene:	LpR2 / 43105	FlyBaseID:	FBgn0051092	Length:	1064	Species:	Drosophila melanogaster
Sequence 2:	NP_004516.2	Gene:	LRP2 / 4036	HGNCID:	6694	Length:	4655	Species:	Homo sapiens

Alignment Length:		Identity:	/ - (0%)
Similarity:	/ - (0%)	Gaps:	/ - (0%)

- Green bases have known domain annotations that are detailed below.

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
LpR2	NP_001097928.1	LDLa	193..224	CDD:197566
		LDLa	235..267	CDD:197566
		LDLa	277..313	CDD:238060
		LDLa	356..388	CDD:197566
		LDLa	400..432	CDD:197566
		LDLa	442..476	CDD:238060
		LDLa	484..517	CDD:197566
		FXa_inhibition	527..562	CDD:291342
		EGF_CA	564..594	CDD:214542
		LY	675..715	CDD:214531
		LY	717..760	CDD:214531
		LY	763..803	CDD:214531
		FXa_inhibition	877..918	CDD:291342
LRP2	NP_004516.2	LDLa	28..62	CDD:238060
		LDLa	108..142	CDD:238060
		LDLa	149..179	CDD:238060
		LDLa	183..217	CDD:238060
		LDLa	222..256	CDD:238060
		LDLa	266..300	CDD:238060
		LY	415..457	CDD:214531
		LDL-receptor class B 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	436..478
		LY	461..501	CDD:214531
		LDL-receptor class B 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	479..521
		LY	503..548	CDD:214531
		LDL-receptor class B 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	522..568
		LY	551..591	CDD:214531
		LDL-receptor class B 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	569..613
		FXa_inhibition	663..704	CDD:291342
		LDL-receptor class B 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	753..795
		LY	776..818	CDD:214531
		LDL-receptor class B 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	796..837
		LDL-receptor class B 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	838..881
		Ldl_recept_b	838..878	CDD:278487
		LY	864..904	CDD:214531
		LDL-receptor class B 8. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	882..925
		FXa_inhibition	981..1013	CDD:291342
		LDLa	1026..1060	CDD:238060
		LDLa	1067..1101	CDD:238060
		LDLa	1109..1143	CDD:238060
		LDLa	1149..1183	CDD:238060
		LDLa	1187..1222	CDD:238060
		LDLa	1230..1264	CDD:238060
		LDLa	1271..1305	CDD:238060
		LDLa	1311..1344	CDD:197566
		FXa_inhibition	1353..1388	CDD:291342
		EGF_CA	1390..1429	CDD:214542
		LY	1461..1500	CDD:214531
		LDL-receptor class B 9. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1478..1520
		LY	1501..1543	CDD:214531
		LDL-receptor class B 10. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1521..1563
		LY	1545..1589	CDD:214531
		LDL-receptor class B 11. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1566..1609
		LY	1591..1632	CDD:214531
		LDL-receptor class B 12. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1610..1654
		LDL-receptor class B 13. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1655..1695
		LDL-receptor class B 14. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1790..1832
		LDL-receptor class B 15. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1833..1882
		LDL-receptor class B 16. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1883..1930
		Ldl_recept_b	1883..1927	CDD:278487
		LY	1911..1953	CDD:214531
		LDL-receptor class B 17. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1931..1972
		LDL-receptor class B 18. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1973..2013
		FXa_inhibition	2022..2058	CDD:291342
		NHL	2091..2300	CDD:302697
		YncE	2092..>2285	CDD:225926
		NHL repeat	2097..2142	CDD:271320
		LDL-receptor class B 19. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2107..2156
		NHL repeat	2147..2186	CDD:271320
		LDL-receptor class B 20. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2157..2201
		NHL repeat	2192..2231	CDD:271320
		LDL-receptor class B 21. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2202..2245
		NHL repeat	2235..2275	CDD:271320
		LDL-receptor class B 22. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2246..2289
		FXa_inhibition	2346..2382	CDD:291342
		LDL-receptor class B 23. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2431..2477
		LY	2459..2500	CDD:214531
		LDL-receptor class B 24. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2478..2518
LY	2500..2542	CDD:214531
LDL-receptor class B 25. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2519..2562
LY	2545..2585	CDD:214531
LDL-receptor class B 26. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2563..2604
LDL-receptor class B 27. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2605..2646
FXa_inhibition	2655..2692	CDD:291342
LDLa	2700..2732	CDD:238060
LDLa	2741..2775	CDD:238060
LDLa	2784..2817	CDD:238060
LDLa	2821..2854	CDD:197566
Ldl_recept_a	2863..2895	CDD:278486
LDLa	2905..2937	CDD:197566
LDLa	2948..2988	CDD:238060
LDLa	2993..3027	CDD:238060
LDLa	3031..3063	CDD:197566
LDLa	3075..3109	CDD:238060
cEGF	3132..3155	CDD:289433
vWFA	<3147..3190	CDD:294047
LY	3219..3260	CDD:214531
LDL-receptor class B 28. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3239..3281
LY	3262..3304	CDD:214531
Ldl_recept_b	3282..3329	CDD:278487
LDL-receptor class B 29. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3282..3324
LDL-receptor class B 30. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3333..3376
Ldl_recept_b	3333..3373	CDD:278487
LY	3358..3399	CDD:214531
LDL-receptor class B 31. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3377..3419
LY	<3408..3441	CDD:214531
LDL-receptor class B 32. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3420..3460
FXa_inhibition	3469..>3498	CDD:291342
LDLa	3512..3544	CDD:197566
LDLa	3553..3584	CDD:197566
LDLa	3594..3626	CDD:238060
LDLa	3634..3666	CDD:197566
LDLa	3682..3714	CDD:238060
LDLa	3719..3754	CDD:238060
LDLa	3759..3793	CDD:238060
LDLa	3798..3832	CDD:238060
LDLa	3885..3915	CDD:197566
LDLa	3928..3962	CDD:238060
EGF_CA	4007..4047	CDD:214542
LY	4141..4176	CDD:214531
LDL-receptor class B 33. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	4154..4196
LDL-receptor class B 34. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	4197..4240
Ldl_recept_b	4197..4237	CDD:278487
LY	4222..4264	CDD:214531
LDL-receptor class B 35. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	4242..4283
SH3-binding. /evidence=ECO:0000255	4453..4462
PxLPxI/L motif 1, mediates interaction with ANKRA2. /evidence=ECO:0000250\|UniProtKB:P98158	4456..4461
PxLPxI/L motif 2, mediates interaction with ANKRA2. /evidence=ECO:0000250\|UniProtKB:P98158	4459..4464
Endocytosis signal. /evidence=ECO:0000255	4521..4526
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4550..4574
Interaction with DAB2. /evidence=ECO:0000269\|PubMed:10769163	4589..4602
NPXY motif	4595..4598
SH2-binding. /evidence=ECO:0000255	4598..4601
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4601..4655
SH3-binding. /evidence=ECO:0000255	4611..4622
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910

Return to query results.
Submit another query.

DRSC/TRiP Functional Genomics Resources

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LpR2 and LRP2

DIOPT Version :9

Known Domains:

Indicated by green bases in alignment.

Information from Original Tools: