DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LpR2 and LRP1

DIOPT Version :9

Sequence 1:	NP_001097928.1	Gene:	LpR2 / 43105	FlyBaseID:	FBgn0051092	Length:	1064	Species:	Drosophila melanogaster
Sequence 2:	XP_016874792.1	Gene:	LRP1 / 4035	HGNCID:	6692	Length:	4561	Species:	Homo sapiens

Alignment Length:	802	Identity:	302/802 - (37%)
Similarity:	421/802 - (52%)	Gaps:	98/802 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 NYCD----EKQF-QCSTGECIPIRFVCDGSSDCPDHSDERLEECKFTESTCSQEQFRCGNGKCIP 250
            :||:    :|.| |||.|.|:.....|:|:.||.|.||    |....::.|...:|||.:|.||.
Human  2576 SYCNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSD----EIPCNKTACGVGEFRCRDGTCIG 2636

  Fly   251 R-------------------------------------------------RWVCDRENDCADGSD 266
            .                                                 .||||..|||.|.||
Human  2637 NSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSD 2701

  Fly   267 ESTSQC---RSHTCSPEEFACKSGEGECIPLSWMCDQNKDCRDGSDEAQCNRTCRSDEFTCGNGR 328
            |  ..|   :...|....|||.|  |.|||:||.||:..||..|.||..||:.|...:|.|.|.|
Human  2702 E--RDCPGVKRPRCPLNYFACPS--GRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHR 2762

  Fly   329 CIQNRFKCDDDDDCGDGSDEKNCGEKAKCGSNFFACK-SGPCIPNQWVCDGDSDCRNGEDE---- 388
            ||..::.||..|||||||||....|...||.:.|:|. :..|:|.:|:||||.||.:|.||
Human  2763 CISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAA 2827

  Fly   389 --MQNCTVSLLNFCQAGEFQCSDRITCLHKSWVCDGEADCPDGEDESQSNCLKVSCRPDQFQCND 451
              :.|.|      |...||.|.:| .|:.|.:|||.:.||.||.||| ..|...:|.|.:|:|.:
Human  2828 GCLYNST------CDDREFMCQNR-QCIPKHFVCDHDRDCADGSDES-PECEYPTCGPSEFRCAN 2884

  Fly   452 QSCIAG-HLTCNGKRDCADGSDEIMCDISATPR--TCNATTEFDCGGGLCIPNAKVCNRRKDCPN 513
            ..|::. ...|:|:.||.|.|||...:...|.:  .|||:::|.|..|.|:..|.:||.:.||.:
Human  2885 GRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGD 2949

  Fly   514 GEDEPAGKCGINEC-SSKNGGCMHQCVNLEVGYRCECHDGYKLGADQHTCVDIDECETPGICSQV 577
            ..||..  |.|||| |.|..||...|.:|::|::|.|..|::|..|..||.|:|||.|...|||.
Human  2950 SSDERG--CHINECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQR 3012

  Fly   578 CVNEIGAFKCECEAGYMRLLKNHTRCKA-SEGHASLLLARRHDIRKIALDRPEMTSIVNSTKAAT 641
            |:|..|::||.|..||.....:...||| ::....|:.|.|:.:||:.||....|.:......|.
Human  3013 CINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAV 3077

  Fly   642 ALDFVFRTGMIFWSDVATQSIYKAPIDEGNDRTVVLTKSSVTS-DGLAVDWIYNHVYFTDTHKCT 705
            ||||.:|..||:|:||.||......:........||.::.::: |||||||:..::|:.|..:.|
Human  3078 ALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDT 3142

  Fly   706 IELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGASPRIERAGMDGTHRTAIITYDVKW 770
            ||::...|:...|||...|..||::.:|...|::||:|||....|.|.||||:.|:.|:...:.|
Human  3143 IEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITW 3207

  Fly   771 PNGITLDLVQKRLYWVDGKLNTISSSNYDGSQRHQVLYSGEYLRHPFSITTFEDYVYWTDWDKQA 835
            |||:|||.|.:|:||.|.:.:.|..::.|||.||.||  .:.:.|.|::|.||||||||||:.::
Human  3208 PNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVL--SQDIPHIFALTLFEDYVYWTDWETKS 3270

  Fly   836 VFKANKFNGMDVEPVTATHMLEHPMVVHVYHPYRQPDGVNH-CQSVNGHCSHLCLPAPRINERSP 899
            :.:|:|..|.:...:.:|  |..||.:||:|..||||..|| |:..||.||:|||.:|....:
Human  3271 INRAHKTTGTNKTLLIST--LHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHK-- 3331

  Fly   900 RISCACPTGLKLMPDGLMCVED 921
               |||||...|..||..||.:
Human  3332 ---CACPTNFYLGSDGRTCVSN 3350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR2	NP_001097928.1	LDLa	193..224	CDD:197566	14/35 (40%)
		LDLa	235..267	CDD:197566	16/80 (20%)
		LDLa	277..313	CDD:238060	18/35 (51%)
		LDLa	356..388	CDD:197566	14/32 (44%)
		LDLa	400..432	CDD:197566	14/31 (45%)
		LDLa	442..476	CDD:238060	13/34 (38%)
		LDLa	484..517	CDD:197566	12/32 (38%)
		FXa_inhibition	527..562	CDD:291342	13/35 (37%)
		EGF_CA	564..594	CDD:214542	15/29 (52%)
		LY	675..715	CDD:214531	15/40 (38%)
		LY	717..760	CDD:214531	19/42 (45%)
		LY	763..803	CDD:214531	17/39 (44%)
		FXa_inhibition	877..918	CDD:291342	17/40 (43%)
LRP1	XP_016874792.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810