| Sequence 1: | NP_001097928.1 | Gene: | LpR2 / 43105 | FlyBaseID: | FBgn0051092 | Length: | 1064 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_000518.1 | Gene: | LDLR / 3949 | HGNCID: | 6547 | Length: | 860 | Species: | Homo sapiens |
| Alignment Length: | 849 | Identity: | 336/849 - (39%) |
|---|---|---|---|
| Similarity: | 468/849 - (55%) | Gaps: | 68/849 - (8%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 236 CSQEQFRCGNGKCIPRRWVCDRENDCADGSDESTSQCRSHTCSPEEFACKSGEGECIPLSWMCDQ 300
Fly 301 NKDCRDGSDEAQC-NRTCRSDEFTCGNGRCIQNRFKCDDDDDCGDGSDEKNCGEKAKCGSNFFAC 364
Fly 365 KSGPCIPNQWVCDGDSDCRNGEDEM-QNCTVSLLNF------CQAGEFQCSDRITCLHKSWVCDG 422
Fly 423 EADCPDGEDESQSNCLKVSCRPDQFQCNDQSCIAGHLTCNGKRDCADGSDEIMCDISATPRTCNA 487
Fly 488 TTEFDCGGGLCIPNAKVCNRRKDCPNGEDEPAGKCGINECSSKNGGCMHQCVNLEVGYRCECHDG 552
Fly 553 YKLGADQHTCVDIDECETPGICSQVCVNEIGAFKCECEAGYMRLLKNHTR-CKASEGHASLLLAR 616
Fly 617 RHDIRKIALDRPEMTSIVNSTKAATALDFVFRTGMIFWSDVATQSIYKAPIDEG---NDRTVVLT 678
Fly 679 KSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSD 743
Fly 744 WGASPRIERAGMDGTHRTAIITYDVKWPNGITLDLVQKRLYWVDGKLNTISSSNYDGSQRHQVLY 808
Fly 809 SGEYLRHPFSITTFEDYVYWTDWDKQAVFKANKFNGMDVEPVTATHMLEHPMVVHVYHPYRQPDG 873
Fly 874 VNHCQSV---NGHCSHLCLPAPRINERSPRISCACPTGLKLMPDGLMCVEDLGIPTVRPTAPMHR 935
Fly 936 TIEQSSNSTTKLPQDGYSETPVETKTGNNR--TDTSNQVHKSDAESENDYVEIALHVIASLAG-- 996
Fly 997 ----------TALVASVIYVVYRRC-----------TRAVNSMNFENPVYHKTTEDHFSLEKNGT 1040
Fly 1041 PHIY 1044 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| LpR2 | NP_001097928.1 | LDLa | 193..224 | CDD:197566 | |
| LDLa | 235..267 | CDD:197566 | 15/30 (50%) | ||
| LDLa | 277..313 | CDD:238060 | 15/35 (43%) | ||
| LDLa | 356..388 | CDD:197566 | 15/31 (48%) | ||
| LDLa | 400..432 | CDD:197566 | 15/31 (48%) | ||
| LDLa | 442..476 | CDD:238060 | 18/33 (55%) | ||
| LDLa | 484..517 | CDD:197566 | 12/32 (38%) | ||
| FXa_inhibition | 527..562 | CDD:291342 | 17/34 (50%) | ||
| EGF_CA | 564..594 | CDD:214542 | 18/29 (62%) | ||
| LY | 675..715 | CDD:214531 | 14/39 (36%) | ||
| LY | 717..760 | CDD:214531 | 17/42 (40%) | ||
| LY | 763..803 | CDD:214531 | 22/39 (56%) | ||
| FXa_inhibition | 877..918 | CDD:291342 | 21/43 (49%) | ||
| LDLR | NP_000518.1 | Ldl_recept_a | 25..58 | CDD:278486 | 15/30 (50%) |
| Ldl_recept_a | 66..104 | CDD:278486 | 16/37 (43%) | ||
| Ldl_recept_a | 107..143 | CDD:278486 | 20/35 (57%) | ||
| Ldl_recept_a | 147..179 | CDD:278486 | 15/31 (48%) | ||
| Ldl_recept_a | 195..231 | CDD:278486 | 17/38 (45%) | ||
| Ldl_recept_a | 235..270 | CDD:278486 | 18/34 (53%) | ||
| LDLa | 278..308 | CDD:294076 | 11/29 (38%) | ||
| FXa_inhibition | 318..>346 | CDD:291342 | 14/27 (52%) | ||
| EGF_CA | 354..388 | CDD:214542 | 19/35 (54%) | ||
| LDL-receptor class B 1 | 397..438 | 15/40 (38%) | |||
| LY | 419..457 | CDD:214531 | 10/37 (27%) | ||
| LDL-receptor class B 2 | 439..485 | 14/45 (31%) | |||
| Ldl_recept_b | 439..482 | CDD:278487 | 11/42 (26%) | ||
| LDL-receptor class B 3 | 486..528 | 12/41 (29%) | |||
| Ldl_recept_b | 487..525 | CDD:278487 | 10/37 (27%) | ||
| LDL-receptor class B 4 | 529..572 | 20/42 (48%) | |||
| Ldl_recept_b | 529..569 | CDD:278487 | 17/39 (44%) | ||
| LY | 553..595 | CDD:214531 | 22/41 (54%) | ||
| LDL-receptor class B 5 | 573..615 | 19/41 (46%) | |||
| LDL-receptor class B 6 | 616..658 | 15/43 (35%) | |||
| Ldl_recept_b | 616..655 | CDD:278487 | 14/40 (35%) | ||
| FXa_inhibition | 671..711 | CDD:291342 | 20/39 (51%) | ||
| Clustered O-linked oligosaccharides | 721..768 | 12/49 (24%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 734..755 | 7/20 (35%) | |||
| Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000269|PubMed:19520913 | 811..860 | 15/37 (41%) | |||
| NPXY motif. /evidence=ECO:0000269|PubMed:22509010 | 823..828 | 3/4 (75%) | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 1 | 1.000 | 55 | 1.000 | Domainoid score | I11132 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG1215 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 713 | 1.000 | Inparanoid score | I644 |
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 1 | 1.010 | - | - | QHG49125 | |
| OrthoDB | 1 | 1.010 | - | - | D179614at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0002088 | |
| OrthoInspector | 1 | 1.000 | - | - | mtm8553 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_103130 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR24270 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R7933 |
| SonicParanoid | 1 | 1.000 | - | - | X1052 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 13 | 12.910 | |||||