DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LpR2 and vldlr

DIOPT Version :9

Sequence 1:	NP_001097928.1	Gene:	LpR2 / 43105	FlyBaseID:	FBgn0051092	Length:	1064	Species:	Drosophila melanogaster
Sequence 2:	XP_005155618.1	Gene:	vldlr / 393897	ZFINID:	ZDB-GENE-040426-803	Length:	877	Species:	Danio rerio

Alignment Length:	888	Identity:	370/888 - (41%)
Similarity:	510/888 - (57%)	Gaps:	71/888 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 CDEKQFQCSTGECIPIRFVCDGSSDCPDHSDERLEECKFTESTCSQEQFRCGNGKCIPRRWVCDR 257
            |::.||||..|.|||..:.|||..||.|.|||  ..|  ...||::..|.|.:|:|||:||.||.
Zfish    29 CEQSQFQCGNGRCIPSVWQCDGDMDCSDGSDE--TSC--VRKTCAEVDFVCRSGQCIPKRWQCDG 89

  Fly   258 ENDCADGSDESTSQCRSHTCSPEEFACKSGEGECIPLSWMCDQNKDCRDGSDEAQC-NRTCRSDE 321
            |.||.||||||...|.:.||...||:|..|..:|||:.|.||..|||.:|.||..| |.||...|
Zfish    90 EPDCEDGSDESIEMCHTRTCRVNEFSCGVGSTQCIPVFWKCDGEKDCDNGEDEINCGNITCAPLE 154

  Fly   322 FTCGNGRCIQNRFKCDDDDDCGDGSDEKNCGEKAKCGSNFFACKSGPCIPNQWVCDGDSDCRNGE 386
            |||.:|||:..:|.|:.:|||||||||::|. .:.|..:...|.:..|||..|:||.|.||::..
Zfish   155 FTCSSGRCVSRKFVCNGEDDCGDGSDEQDCA-PSSCSPSEIPCGNNTCIPRSWLCDDDVDCQDQS 218

  Fly   387 DEM-----QNCTVSLLNFCQAGEFQCSDRITCLHKSWVCDGEADCPDGEDESQSNCLKVSCRPDQ 446
            ||.     .|.|....  |...|.||... .|:|:.|.|||:.||.||.||  .||...:|||||
Zfish   219 DESPERCGHNPTPPAK--CSPSEMQCGSG-ECIHRKWRCDGDPDCKDGSDE--KNCSARNCRPDQ 278

  Fly   447 FQCNDQSCIAGHLTCNGKRDCADGSDEIMCDISATPRTCNATTEFDCGGGLCIPNAKVCNRRKDC 511
            |:|:|.|||.|...|||.|||.||:||:.|   .....||::.:|.|..|.||..:||||:.:||
Zfish   279 FKCDDGSCIHGSRQCNGFRDCVDGTDEVNC---KNLTQCNSSDQFKCRSGECIEMSKVCNKVRDC 340

  Fly   512 PNGEDEPAGKCGINECSSKNGGCMHQCVNLEVGYRCECHDGYKLGADQHTCVDIDECETPGICSQ 576
            |:..|||..:|.:|||...||||.|.|.:|.:|:.|:|..|.:| .|:.||.|::||..||||||
Zfish   341 PDWSDEPIKECNMNECLINNGGCSHICRDLTIGFECDCTPGLQL-IDRKTCGDVNECLNPGICSQ 404

  Fly   577 VCVNEIGAFKCECEAGYMRLLKNHTRCKASEGHASLLLARRHDIRKIALDRPEMTSIVNSTKAAT 641
            :|:|..|.:||||..|| ::......|||......|:...|.||||:.|:|.|.|.||...:...
Zfish   405 ICINLKGGYKCECHNGY-QMDPTTGVCKAVGKEPCLIFTNRRDIRKLGLERREYTQIVEQLRNTV 468

  Fly   642 ALDFVFRTGMIFWSDVATQSIYKAPIDEGNDRTVVLTKSSVTSD-----GLAVDWIYNHVYFTDT 701
            |||..|...||||:|:..::|:...:|:.::     :...|..|     |:||||||.::|::|.
Zfish   469 ALDADFIQQMIFWADLGQKAIFSTVLDKQDE-----SHKKVIDDVQMPVGIAVDWIYKNIYWSDL 528

  Fly   702 HKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGASPRIERAGMDGTHRTAIITY 766
            ...:|.:.||.|:..|||....|..|.|||:||:.|::||||||...:||::||:|..|..::..
Zfish   529 GSKSITVANFNGTKKKVLFNSGLKEPASIAVDPLSGFLYWSDWGEPAKIEKSGMNGNDRQVLVET 593

  Fly   767 DVKWPNGITLDLVQKRLYWVDGKLNTISSSNYDGSQRHQVLYSGEYLRHPFSITTFEDYVYWTDW 831
            |::|||||||||::.||||||.||:.:.|.:.:|..|.:||.|.:||.|||::|.|||.|:|||.
Zfish   594 DIQWPNGITLDLIKGRLYWVDSKLHMLCSVDLNGDNRRKVLQSPDYLAHPFALTVFEDRVFWTDG 658

  Fly   832 DKQAVFKANKFNGMDVEPVTATHMLEHPMVVHVYHPYRQPDGVNHC--QSVNGHCSHLCLPAPRI 894
            :.:|::.||||.|.||..:.:.  |..|..:.|||...|..|.|.|  :..||.||.:|||||:|
Zfish   659 ENEAIYGANKFTGSDVTLLASN--LNEPQDIIVYHELIQLSGTNWCNEKMENGGCSFMCLPAPQI 721

  Fly   895 NERSPRISCACPTGLKLMPDGLMC--------VEDLGIPTVRPTAPMHRTIEQSSNSTTKLPQDG 951
            |:.||:.:|.||.|..|..|||.|        .:|.|..|.||:.|       .::|.:|:..:
Zfish   722 NKHSPKYTCVCPEGQTLASDGLRCRAEATSAAPQDGGQVTTRPSHP-------KASSVSKVASE- 778

  Fly   952 YSETPVETKTGNNRTDTSNQVHKSDAESENDYVEIALHVIASLAGTALVASVIYVVYRRC-TRAV 1015
                ||.|: ||    .|..:|:.:..:.......|:..:..|   |:.|:..|:::|.. .:..
Zfish   779 ----PVHTE-GN----LSTSIHEVNTSARGSAAAWAILPVLLL---AMAAAGGYLMWRNWQIKNK 831

  Fly  1016 NSMNFENPVYHKTTEDHFSLE----KNGTPHIYAA---ANDEE 1051
            .||||:||||.||||:..:::    .....|.|.|   .|.|:
Zfish   832 KSMNFDNPVYLKTTEEDLNIDISRHSASVGHTYPAISMVNTED 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR2	NP_001097928.1	LDLa	193..224	CDD:197566	16/30 (53%)
		LDLa	235..267	CDD:197566	18/31 (58%)
		LDLa	277..313	CDD:238060	17/35 (49%)
		LDLa	356..388	CDD:197566	11/31 (35%)
		LDLa	400..432	CDD:197566	14/31 (45%)
		LDLa	442..476	CDD:238060	22/33 (67%)
		LDLa	484..517	CDD:197566	14/32 (44%)
		FXa_inhibition	527..562	CDD:291342	14/34 (41%)
		EGF_CA	564..594	CDD:214542	17/29 (59%)
		LY	675..715	CDD:214531	15/44 (34%)
		LY	717..760	CDD:214531	22/42 (52%)
		LY	763..803	CDD:214531	20/39 (51%)
		FXa_inhibition	877..918	CDD:291342	22/42 (52%)
vldlr	XP_005155618.1	LDLa	29..63	CDD:238060	18/35 (51%)
		LDLa	67..99	CDD:197566	18/31 (58%)
		Ldl_recept_a	107..145	CDD:278486	18/37 (49%)
		Ldl_recept_a	149..184	CDD:278486	20/34 (59%)
		Ldl_recept_a	234..269	CDD:278486	16/39 (41%)
		Ldl_recept_a	272..308	CDD:278486	22/35 (63%)
		LDLa	316..346	CDD:238060	12/29 (41%)
		FXa_inhibition	356..390	CDD:291342	14/34 (41%)
		EGF_CA	392..426	CDD:214542	18/34 (53%)
		NHL	479..>570	CDD:302697	34/95 (36%)
		LY	504..541	CDD:214531	14/36 (39%)
		NHL repeat	511..551	CDD:271320	16/39 (41%)
		Ldl_recept_b	564..604	CDD:278487	20/39 (51%)
		LY	588..630	CDD:214531	20/41 (49%)
		Ldl_recept_b	651..690	CDD:278487	15/40 (38%)
		FXa_inhibition	707..745	CDD:291342	21/37 (57%)
		Mucin	<723..817	CDD:250634	29/113 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10830
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H443
Inparanoid	1	1.050	720	1.000	Inparanoid score	I618
OMA	1	1.010	-	-		QHG49125
OrthoDB	1	1.010	-	-		D179614at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6597
orthoMCL	1	0.900	-	-		OOG6_103130
Panther	1	1.100	-	-	O	PTHR24270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7933
SonicParanoid	1	1.000	-	-		X1052
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870