DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LpR2 and ldlra

DIOPT Version :9

Sequence 1:	NP_001097928.1	Gene:	LpR2 / 43105	FlyBaseID:	FBgn0051092	Length:	1064	Species:	Drosophila melanogaster
Sequence 2:	NP_001025454.1	Gene:	ldlra / 387529	ZFINID:	ZDB-GENE-031217-1	Length:	911	Species:	Danio rerio

Alignment Length:	932	Identity:	334/932 - (35%)
Similarity:	459/932 - (49%)	Gaps:	170/932 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 TCSQEQFRCGNGKCIPRRWVCDRENDCADGSDESTSQCRSHTCSPEEFACKSGEGECIPLSWMCD 299
            ||...|::|||||||..|||||..:||.||:||..:.|.:.||.|.:|:|.....:|||.||.||
Zfish    23 TCDSRQYQCGNGKCITARWVCDETDDCGDGTDELPAACLAKTCRPSQFSCGGRLNQCIPKSWKCD 87

  Fly   300 QNKDCRDGSDEAQCN-RTCRSDEFTCGNGRCIQNRFKCDDDDDCGDGSDEKNCGEKAKCGSNFFA 363
            ...||.:.:||..|: |.|...||.||:|:|:...|.|||:.||.|||||.:| ....|||:.|.
Zfish    88 GKADCENNADEEGCDPRQCHDGEFRCGSGQCVTAAFVCDDEIDCEDGSDEVSC-PPTTCGSSSFR 151

  Fly   364 CKSGPCIPNQWVCDGDSDCRNGEDEM-QNC----TVSLLNFCQAGEFQCSDRITCLHKSWVCDGE 423
            |.:..|:|..||||||:||.:..||: :.|    :....|.|.:.||.|... .|:|.||.|||.
Zfish   152 CNNAQCVPRLWVCDGDADCADNSDELPEKCGPGTSKPTKNPCTSMEFHCGSG-ECIHGSWKCDGG 215

  Fly   424 ADCPDGEDESQSNCLKVSCRPDQFQCNDQSCIAGHLTCNGKRDCADGSDEIMCDISATPRTCNAT 488
            |||.|..||  .||...:||||:|||.|.|||.|...||...||.|.|||:.| ::||  .|...
Zfish   216 ADCLDHSDE--QNCSLPTCRPDEFQCGDGSCIHGSRQCNHVYDCKDMSDELGC-VNAT--HCEPP 275

  Fly   489 TEFDCGGGLCIPNAKVCNRRKDCPNGEDEPAGKCGINECSSKNGGCMHQCVNLEVGYRCECHDGY 553
            ..|.|..|.||...||||:::||.:..|||..:|..|||...||||.|.|.:|::||.|.|..|:
Zfish   276 YRFKCRSGECISMEKVCNKQRDCRDWSDEPLRECDSNECLYNNGGCSHICNDLKIGYECLCPTGF 340

  Fly   554 KLGADQHTCVDIDECETPGICSQVCVNEIGAFKCECEAGYMRLLKNHTRCKASEGHASLLLARRH 618
            :| .|:..|.|||||..|..|||:|||::|::|||||.|| ::......|||....|.|....||
Zfish   341 RL-VDKRRCEDIDECANPDTCSQICVNQMGSYKCECEDGY-QMDPASKACKAIGTIAYLFFTNRH 403

  Fly   619 DIRKIALDRPEMTSIVNSTKAATALDFVFRTGMIFWSDVATQSIYKAPIDEGNDRTVVLTKSSVT 683
            ::||:.|||.|...::...|...|||....:..|:|||::.:.||..
Zfish   404 EVRKMTLDRSEYIRVIPRLKNVVALDMNIASRDIYWSDLSLKKIYSI------------------ 450

  Fly   684 SDGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGASP 748
                               :..|.:...:||..|.|.|::|..||:|.:|||:.:|:|:|||...
Zfish   451 -------------------RGAISVATADGSRRKTLFKENLAKPRAIVVDPIKNFMFWTDWGTPA 496

  Fly   749 RIERAGMDGTHRTAIITYDVKWPNGITLDLVQKRLYWVDGKLNTISSSNYDGSQRHQVLYSGEYL 813
            :||::|::|..|:.::..|:.|||||||||:.:||||||.||:|:||.:..|..|..::.....|
Zfish   497 KIEKSGLNGVDRSTLVADDIVWPNGITLDLLTERLYWVDSKLHTLSSISVQGDGRRTLIIDQGKL 561

  Fly   814 RHPFSITTFEDYVYWTDWDKQAVFKANKFNGMDVEPVTATHMLEHPMVVHVYHPYRQPDGVNHCQ 878
            .||.|:|.||:.|:|||....|:..||:..|.|:..| |.| |..|..:.::|..:||.|:|.|:
Zfish   562 AHPLSLTVFEEKVFWTDVSNNAILSANRVTGGDITKV-AEH-LSSPEDIVLFHNLKQPTGINWCR 624

  Fly   879 SVNGHCSHLCLPAPRINERSPRISCACPTGLKLMPDGLMCVEDL---------GIP-TVRPTAPM 933
            ..||.|..|||.||:||..||:.:||||..:.|..|...||..:         .|| |:||..|.
Zfish   625 INNGGCEFLCLAAPQINRFSPKYTCACPDNMMLARDMRKCVPAVVTAATPVRPEIPTTIRPQVPS 689

  Fly   934 HRTIEQS-----------------------------SNSTTKLP---------------QDGYSE 954
            ..|.:.:                             |.:|||||               .|..|.
Zfish   690 ETTPKPARPSTTNSQPLPTPAPKIPNRPTQAATLVPSQATTKLPFFTQTDVHFGDVKAVSDTSSS 754

  Fly   955 T-----------PVETKTGNN----------------------------RTDTSN---------- 970
            |           |....:|.|                            .|||.|
Zfish   755 TLWALYIVVPLVPFIIHSGMNHQLIQHVFRQRMPFQPQPISRKHPHTLIHTDTDNLAYPIHLYRL 819

  Fly   971 ------------QVHKSDAESENDYVEIALHVIASLAGTALVASVIYVVYRRC-TRAVNSMNFEN 1022
                        ..|:.:.::.:......|:...|.:...||.....:.:|:. .:..||::|:|
Zfish   820 TVGETGAPGGSPHEHRENIQTPHRNTSCGLNQRPSCSLLCLVVGGAALFWRKWRQKNTNSIHFDN 884

  Fly  1023 PVYHKTTEDHFSLEKNGTPHIY 1044
            |||.|||||...|.:|.:...|
Zfish   885 PVYQKTTEDQVHLCRNNSSDGY 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR2	NP_001097928.1	LDLa	193..224	CDD:197566
		LDLa	235..267	CDD:197566	19/31 (61%)
		LDLa	277..313	CDD:238060	15/35 (43%)
		LDLa	356..388	CDD:197566	15/31 (48%)
		LDLa	400..432	CDD:197566	15/31 (48%)
		LDLa	442..476	CDD:238060	20/33 (61%)
		LDLa	484..517	CDD:197566	12/32 (38%)
		FXa_inhibition	527..562	CDD:291342	15/34 (44%)
		EGF_CA	564..594	CDD:214542	19/29 (66%)
		LY	675..715	CDD:214531	2/39 (5%)
		LY	717..760	CDD:214531	19/42 (45%)
		LY	763..803	CDD:214531	22/39 (56%)
		FXa_inhibition	877..918	CDD:291342	19/40 (48%)
ldlra	NP_001025454.1	LDLa	23..55	CDD:197566	19/31 (61%)
		Ldl_recept_a	63..101	CDD:365841	16/37 (43%)
		LDLa	106..140	CDD:238060	18/33 (55%)
		LDLa	144..176	CDD:197566	15/31 (48%)
		Ldl_recept_a	192..227	CDD:365841	17/37 (46%)
		Ldl_recept_a	231..266	CDD:365841	20/34 (59%)
		LDLa	274..304	CDD:238060	11/29 (38%)
		FXa_inhibition	314..348	CDD:373209	15/34 (44%)
		EGF_CA	350..380	CDD:214542	20/30 (67%)
		Ldl_recept_b	437..481	CDD:278487	16/80 (20%)
		Ldl_recept_b	485..525	CDD:278487	17/39 (44%)
		LY	510..551	CDD:214531	22/40 (55%)
		Ldl_recept_b	572..611	CDD:278487	14/40 (35%)
		FXa_inhibition	623..664	CDD:373209	19/40 (48%)
		PHA03247	<666..808	CDD:223021	21/141 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10830
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49125
OrthoDB	1	1.010	-	-		D179614at33208
OrthoFinder	1	1.000	-	-		FOG0002088
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103130
Panther	1	1.100	-	-	LDO	PTHR24270
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7933
SonicParanoid	1	1.000	-	-		X1052
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.950