DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LpR2 and Lrp8

DIOPT Version :9

Sequence 1:	NP_001097928.1	Gene:	LpR2 / 43105	FlyBaseID:	FBgn0051092	Length:	1064	Species:	Drosophila melanogaster
Sequence 2:	XP_006238632.1	Gene:	Lrp8 / 362558	RGDID:	1305729	Length:	1013	Species:	Rattus norvegicus

Alignment Length:	939	Identity:	354/939 - (37%)
Similarity:	502/939 - (53%)	Gaps:	101/939 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 PLDISLGLSNYCDEKQFQCSTGECIPIRFVCDGSSDCPDHSDERLEECKFTESTCSQEQFRCGNG 246
            ||....|....|:|.||:|....|||..:.||..:||.|:|||  ::|  .:.||:...|.|.||
  Rat    33 PLPGGQGPVKECEEDQFRCRNERCIPSVWRCDEDNDCSDNSDE--DDC--PKRTCTDSDFTCDNG 93

  Fly   247 KCIPRRWVCDRENDCADGSDESTSQCRSHTCSPEEFACKSGEGECIPLSWMCDQNKDCRDGSDEA 311
            .|||.||.||.|.:|.||||||.:.|.|..|..|:.:|.....:|:|.||.||..|||..|:|||
  Rat    94 HCIPERWKCDGEEECPDGSDESKATCSSEECPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA 158

  Fly   312 QCNRTCRSDEFTCGNGRCIQNRFKCDDDDDCGDGSDEKNCGEKAKCGSNFFAC-KSGPCIPNQWV 375
            .|...|...||.|.|..|:.:.|.||.||||||||||:.|.:.| |....|.| ..|.|||.:||
  Rat   159 GCPTLCAPHEFQCSNRSCLASVFVCDGDDDCGDGSDERGCSDPA-CPPREFRCGGGGTCIPERWV 222

  Fly   376 CDGDSDCRNGEDEMQN---------------CTVSLLNFCQAGEFQCSDRITCLHKSWVCDGEAD 425
            |||..||.:..||...               |..:....|::||        |:|..|.|||:.|
  Rat   223 CDGQFDCEDRSDEAAELCGRAGQGTTATPAACAPTTQFTCRSGE--------CIHLGWRCDGDRD 279

  Fly   426 CPDGEDESQSNCLKVSCRPDQFQCNDQSCIAGHLTCNGKRDCADGSDEIMCDISATPRTCNATTE 490
            |.|..||:..:. ...||.:.|||.|.:||.....||.:|||.|||||..|   ....||.....
  Rat   280 CKDKSDEADCSA-PGPCRENDFQCGDGTCILAIKRCNQERDCLDGSDEAGC---LQESTCEGPRR 340

  Fly   491 FDCGGGLCIPNAKVCNRRKDCPNGEDEPAGKC-------------GINECSSKNGGCMHQCVNLE 542
            |.|..|.|:...|||:.::||.:..|||...|             |:|||...||||.|.|.:|:
  Rat   341 FQCKSGECVDGGKVCDDQRDCRDWSDEPQKVCVAPIFQGNRRRPRGLNECLHNNGGCSHICTDLK 405

  Fly   543 VGYRCECHDGYKLGADQHTCVDIDECETPGICSQVCVNEIGAFKCECEAGYM--RLLKNHTRCKA 605
            :|:.|.|..|::| .||.||.|||||:.|..|||:|||..|.|||||..||.  .|.||   |||
  Rat   406 IGFECTCPAGFQL-LDQKTCGDIDECQDPDACSQICVNYKGYFKCECHPGYEMDTLTKN---CKA 466

  Fly   606 SEGHA-SLLLARRHDIRKIALDRPEMTSIVNSTKAATALDFVFRTGMIFWSDVATQSIYKAPIDE 669
            ..|.: ||:...||::|:|.|.:.:.:.::...|...|||....|..|:|.|::.:.||.|.:|:
  Rat   467 VAGRSPSLIFTNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVDTNRIYWCDLSYRKIYSAHMDK 531

  Fly   670 GN--DRTVVLTKSSVTS-DGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIA 731
            .:  |..|||....:.| :||||||::.|:|:||:...|:.:...:|.....|....|..||:||
  Rat   532 ASIPDEQVVLIGEQLHSPEGLAVDWVHKHIYWTDSGNKTVSVATTDGRRRCTLFNRDLSEPRAIA 596

  Fly   732 LDPIEGWMYWSDWGASPRIERAGMDGTHRTAIITYDVKWPNGITLDLVQKRLYWVDGKLNTISSS 796
            :||:.|:|||||||...:||:||::|..|..:::.:::|||||||||:.:||||||.||:.:||.
  Rat   597 VDPLRGFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSI 661

  Fly   797 NYDGSQRHQVLYSGEYLRHPFSITTFEDYVYWTDWDKQAVFKANKFNGMDVEPVTATHMLEHPMV 861
            :::|..|..:::|.::|.|||.:..|||.|:|||.:.:|:|.||:.||:::..:...  |.:|..
  Rat   662 DFNGGNRKMLIFSTDFLSHPFGVAVFEDKVFWTDLENEAIFSANRLNGLEISILAEN--LNNPHD 724

  Fly   862 VHVYHPYRQPDGVNHCQ---SVNGHCSHLCLPAPRINERSPRISCACPTGLKLMPDGLMCVEDLG 923
            :.::|..:||...:.|:   ..||.|.:||||||:|:..||:.:||||..:.|.||...|..  .
  Rat   725 IVIFHELKQPKAADACELSAQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYR--A 787

  Fly   924 IPTVRPT---APMHRTIEQSS-------------NSTTKLPQD------------GYSETPVETK 960
            .|:...|   :.|.||:..::             |.:|::|..            .:|.:|   .
  Rat   788 PPSTSTTTLASAMTRTVPATTGAPGTTIHDSTYQNHSTEMPSQTAAVPHSVNIPKAHSTSP---S 849

  Fly   961 TGNNRTDTSNQVHKSDAESENDYVEIA-LHVIASLAGTALVASVIYVVYRRCTRA-VNSMNFENP 1023
            |.:..|...:|.:.::.......|..| :.:|..:...||:....|:::|...|. ..||||:||
  Rat   850 TLSPATSNHSQHYGNEGSQMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNP 914

  Fly  1024 VYHKTT----EDHFSLEKNG-TPHIYAAA 1047
            ||.|||    ||...:.:.. ..|:|.||
  Rat   915 VYRKTTEEEEEDELHIGRTAQIGHVYPAA 943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR2	NP_001097928.1	LDLa	193..224	CDD:197566	14/30 (47%)
		LDLa	235..267	CDD:197566	18/31 (58%)
		LDLa	277..313	CDD:238060	16/35 (46%)
		LDLa	356..388	CDD:197566	14/32 (44%)
		LDLa	400..432	CDD:197566	12/31 (39%)
		LDLa	442..476	CDD:238060	18/33 (55%)
		LDLa	484..517	CDD:197566	11/32 (34%)
		FXa_inhibition	527..562	CDD:291342	15/34 (44%)
		EGF_CA	564..594	CDD:214542	19/29 (66%)
		LY	675..715	CDD:214531	16/40 (40%)
		LY	717..760	CDD:214531	21/42 (50%)
		LY	763..803	CDD:214531	20/39 (51%)
		FXa_inhibition	877..918	CDD:291342	20/43 (47%)
Lrp8	XP_006238632.1	LDLa	44..78	CDD:238060	16/35 (46%)
		LDLa	82..114	CDD:197566	18/31 (58%)
		LDLa	124..160	CDD:238060	16/35 (46%)
		LDLa	203..235	CDD:197566	14/31 (45%)
		LDLa	256..289	CDD:238060	14/40 (35%)
		LDLa	295..329	CDD:238060	18/33 (55%)
		LDLa	333..369	CDD:294076	13/35 (37%)
		FXa_inhibition	390..424	CDD:291342	15/34 (44%)
		EGF_CA	426..456	CDD:214542	19/29 (66%)
		LY	495..530	CDD:214531	11/34 (32%)
		LY	540..581	CDD:214531	15/40 (38%)
		Ldl_recept_b	602..642	CDD:278487	20/39 (51%)
		LY	626..668	CDD:214531	20/41 (49%)
		Ldl_recept_b	689..728	CDD:278487	13/40 (33%)
		FXa_inhibition	747..784	CDD:291342	19/36 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I10838
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	710	1.000	Inparanoid score	I619
OMA	1	1.010	-	-		QHG49125
OrthoDB	1	1.010	-	-		D179614at33208
OrthoFinder	1	1.000	-	-		FOG0002088
OrthoInspector	1	1.000	-	-		mtm9029
orthoMCL	1	0.900	-	-		OOG6_103130
Panther	1	1.100	-	-	O	PTHR24270
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1052
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880