DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LpR2 and Ndg

DIOPT Version :9

Sequence 1:	NP_001097928.1	Gene:	LpR2 / 43105	FlyBaseID:	FBgn0051092	Length:	1064	Species:	Drosophila melanogaster
Sequence 2:	NP_610575.1	Gene:	Ndg / 36089	FlyBaseID:	FBgn0026403	Length:	1350	Species:	Drosophila melanogaster

Alignment Length:	987	Identity:	228/987 - (23%)
Similarity:	339/987 - (34%)	Gaps:	314/987 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 ATPTASEIMHNLSGSAL--LERLKASTLGPTLDQLKHLAPAAANSISPGTGSGMGIGMGHFGSSI 161
            |.|:|::::..:|..||  :||.:|..:|
  Fly   507 ADPSATKVLQKISKVALDYVERDQALRIG------------------------------------ 535

  Fly   162 NSVLNGNPLKFLNVSGKIG-TPLDISLGLSNYCDEKQFQC-STGECIPIR--FVCDGSSDCPDHS 222
                         ...|:| ||      .||.|::....| ....|:|..  :.||.........
  Fly   536 -------------AMSKVGVTP------ESNACNDGTADCVENSVCVPYEDTYRCDCYHGFAAQL 581

  Fly   223 DER-------LEECKFTESTCSQEQ--------FRC-------GNG-KCIPRRWVCDRENDCAD- 263
            |||       ::||......|.:..        |.|       ||| :|:        .|..||
  Fly   582 DERGVEVCLDIDECATGSHVCDENAVCDNTEGGFNCYCTEGFEGNGYRCL--------SNSTADN 638

  Fly   264 --------GSDESTSQCRSHTCS-------------------------PEEFACKSGEGECIPLS 295
                    |..|.||:...:...                         ||| .......||
  Fly   639 IEYPPAVEGQAEPTSEPSPNPSPYPDQGQDQEREREDDQYPQPNPYPYPEE-QIPQHPDEC---- 698

  Fly   296 WMCDQNKDCRDGSDEAQCNRTCRSDEFTC----------GNGRCIQNRFKCDDDDDCGDGSDEKN 350
            :.|.::.||..|  ...|:.....|.:||          .||||.....:..|.|...|...|..
  Fly   699 YRCSKDADCYQG--RCTCHEGFDGDGYTCTNICGHGEVWENGRCEPLLLERHDVDPLCDALGECR 761

  Fly   351 C-------GEKAKCG--SNFFACKSGPCIPNQWVCDGDSDCR-------NGEDEMQNCTVSLLNF 399
            |       .:..:|.  ..|...::...||    ||.|.:|.       .|::....||
  Fly   762 CPYGYELSEDSQRCTYVQEFDGERNADLIP----CDVDENCHINATCNWYGQELRHICT------ 816

  Fly   400 CQAG----EFQC---SDRITCLHKSWVCDGEADCPDGEDESQSNCLKVSCRPDQFQCNDQSCIAG 457
            ||.|    .:.|   ||. :|..:..:||..|||...|...:|.|               .|.||
  Fly   817 CQPGFRGDGYNCDPISDD-SCAIRPDICDVHADCVYEEHLGKSEC---------------QCQAG 865

  Fly   458 H----------LTCNGKRDCADGS--DEIMCDISATPRTCNATTEFD----------CGGGLCIP 500
            :          ..|.....|.:.:  |:.:|       .|.|..|.|          ||...|..
  Fly   866 YTGNGFNCQLAAECQSAEHCGENAFCDDGVC-------RCQADFERDVSDRCVPAGRCGSVFCGS 923

  Fly   501 NAKVCN-------RRKDCPNGEDEPAGKCGINECSSK--------NGGCMHQCVNLE--VGYRCE 548
            || :|.       :..||.:|....|    :..|:||        |.|....|...|  ..|.|:
  Fly   924 NA-ICKWDSAEGVQYCDCLDGYQGDA----LTGCTSKPLSCHVLNNCGIHATCEPTEDPANYECQ 983

  Fly   549 CHDGYKLGADQHTCVDIDEC-ETPGIC--SQVCVNEIGAFKCECEAGYMRLLKNHTRCKASEGHA 610
            |..|:|  .|.:.|::...| ..|.:|  :..|.:......|.|..|:.             |:.
  Fly   984 CIAGFK--GDGYVCIEEQNCLNNPTLCDMNAQCRSTNSGLVCVCNQGFF-------------GNG 1033

  Fly   611 SLLLARRHD------------IRKIALD----RPEMTSIVNSTKAATALDFVFRTGMIFWSDVAT 659
            ||...|:|.            |.::.|:    ||     ::..:.|..||.....|.::|.|::|
  Fly  1034 SLCQERQHQDSDFLIVSQGVMIARVPLNGRNVRP-----ISVAQMAIGLDKDCVEGRVYWGDIST 1093

  Fly   660 QSIYKAPIDEGNDRTVVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEG-SMGKVLVKDS 723
            :.|.....| |.|....:|....:.:|:|:|.|...:|:.|:.|.|||:.:.:. |:..|::...
  Fly  1094 KKIVSTKYD-GTDLRPFITTDIESPEGIAIDVISRRLYWADSAKDTIEVASLDDPSLRAVIINKQ 1157

  Fly   724 LDIPRSIALDPIEGWMYWSDWG-ASPRIERAGMDGTHRTAII-TYDVKWPNGITLDLVQKRLYWV 786
            |..||.||:||....::||||. .||:||.:.:|||.|..:: ..||..||.:.:......:.:.
  Fly  1158 LVNPRGIAVDPYREKLFWSDWDRESPKIEMSNLDGTGRELLLGKDDVTLPNSLVVLENSGEVCYA 1222

  Fly   787 DG---KLNTISSSNYDGSQRHQVLYSGEYLRHPFSITTFEDYVYWTDWDKQAVFKANKFNGMDV- 847
            |.   |:..|...|      .|:......|.:||.||...|..|||||..:.|...:.......
  Fly  1223 DAGTKKVECIEPQN------RQIRTISNELSYPFGITFTHDQFYWTDWTTKKVEIVDSLGARQTP 1281

  Fly   848 --EPVTATHMLEHPMVVHVYHP-YRQPDGVNHCQSVNGHC--SHLCLPAPRINERSPR-ISCAC- 905
              .|...:|.:....||..:.| |:.|     ||..||.|  |.|||    :|.::|. .||.|
  Fly  1282 IQPPFFGSHKMYGMTVVEQHCPQYQSP-----CQISNGGCTDSRLCL----VNRQAPSGKSCKCT 1337

  Fly   906 --PTGLKLMPDG 915
              .||..::..|
  Fly  1338 SASTGCTVLAPG 1349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR2	NP_001097928.1	LDLa	193..224	CDD:197566	6/33 (18%)
		LDLa	235..267	CDD:197566	11/56 (20%)
		LDLa	277..313	CDD:238060	9/60 (15%)
		LDLa	356..388	CDD:197566	9/40 (23%)
		LDLa	400..432	CDD:197566	13/38 (34%)
		LDLa	442..476	CDD:238060	6/45 (13%)
		LDLa	484..517	CDD:197566	13/49 (27%)
		FXa_inhibition	527..562	CDD:291342	13/44 (30%)
		EGF_CA	564..594	CDD:214542	7/32 (22%)
		LY	675..715	CDD:214531	11/40 (28%)
		LY	717..760	CDD:214531	19/43 (44%)
		LY	763..803	CDD:214531	8/43 (19%)
		FXa_inhibition	877..918	CDD:291342	17/45 (38%)
Ndg	NP_610575.1	NIDO	108..262	CDD:214712
		EGF_3	285..320	CDD:372403
		G2F	322..549	CDD:214774	16/96 (17%)
		EGF_CA	591..627	CDD:311536	6/35 (17%)
		EGF_3	797..828	CDD:372403	7/36 (19%)
		EGF_3	836..873	CDD:372403	12/51 (24%)
		EGF_3	963..995	CDD:372403	10/33 (30%)
		EGF_3	1001..1036	CDD:372403	9/47 (19%)
		NHL	1059..>1275	CDD:302697	67/227 (30%)
		NHL repeat	1067..1103	CDD:271320	10/41 (24%)
		Ldl_recept_b	1084..1123	CDD:393440	11/39 (28%)
		LY	1107..1145	CDD:214531	11/37 (30%)
		NHL repeat	1117..1154	CDD:271320	12/36 (33%)
		LY	1152..1195	CDD:214531	19/42 (45%)
		NHL repeat	1161..1198	CDD:271320	18/36 (50%)
		NHL repeat	1204..1245	CDD:271320	8/46 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461699
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840