DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LpR2 and CG6739

DIOPT Version :9

Sequence 1:	NP_001097928.1	Gene:	LpR2 / 43105	FlyBaseID:	FBgn0051092	Length:	1064	Species:	Drosophila melanogaster
Sequence 2:	NP_609130.1	Gene:	CG6739 / 34037	FlyBaseID:	FBgn0031926	Length:	787	Species:	Drosophila melanogaster

Alignment Length:	661	Identity:	133/661 - (20%)
Similarity:	198/661 - (29%)	Gaps:	242/661 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 YFQTTTQSELTTNESANSRSSSSSSGCREPSKTSGFFYSASTHYQSKVQQLI------------- 63
            |..|.|.:..::||..:..::||:.  |.|.:|:.......:...:::.::.
  Fly   162 YEATLTSTSSSSNEVWDEETTSSTE--RSPQETTRLEDMDDSDESTELPEIAFGDDGDPEAGGED 224

  Fly    64 -------------SFSFTSSFHLLFITCI------LSISKFCNAAAVNAAHVTAATPTASEIMHN 109
                         |..|||.....|...|      |.:.|       ...|...|||..:|....
  Fly   225 GDGDYDDTLLPADSIRFTSGHQNSFGVPIEQDKRMLQLLK-------ELLHKPQATPAGNEPTLT 282

  Fly   110 LSGSALLERLKASTLGPTLDQLKHLAPAAANSISPGTGSGM-----------------------G 151
            .....|...|.||  |...:.:....|:..||   |..|.|                       .
  Fly   283 RVSPTLPPPLSAS--GRPTEAMALTTPSTTNS---GCQSTMLPMCQGVLDYDLTFNREGAAPRDA 342

  Fly   152 IGMGHFGSSINSVLNGNPLKFLNVSGKIGTPLDISLGLSNYCDEKQFQC---STGECIPIRFVC- 212
            :.|..:.|.|.:..:....:|:                   |...:.:|   ..|:..|.|.:|
  Fly   343 VSMAAYDSLIRANCSVRAAEFI-------------------CGALEPECRPLHIGQLPPCRRICK 388

  Fly   213 ---DGSS-------------DC---PD-HSDERLEECKFTESTCSQEQFRCGNGKCIPRRWVCDR 257
               :..|             ||   || |...:.|:.......|...:|:|.:|.|||:.|.||:
  Fly   389 AILEACSIPIYNSDVLGELFDCNLYPDAHESHKCEDPTRRRDYCYGNEFQCHDGSCIPQNWQCDK 453

  Fly   258 ENDCADGSDESTSQCRSHTCSPEEFACKSGEGECIPLSWMCDQNKDCRDGSDEAQCNRTCRSDEF 322
            ..||..|.||. .||.  .|.|:||.|:|.| :|:...:.||||.||.|||||..|      ||:
  Fly   454 IKDCQGGEDED-EQCL--VCEPDEFRCRSNE-KCLVEKYRCDQNIDCMDGSDEQDC------DEY 508

  Fly   323 TCG----------------------------NGRCIQNRFKCDDDDDCG---------------- 343
            ..|                            |.: :........|:|.|
  Fly   509 GSGDLAPFDESELNAFPRVFTYASFLSPNETNDK-VYTYITATTDEDAGTETKFQIHQVAAPAPP 572

  Fly   344 -DGSDEKNCG---------------------------EKAKCGSNFF--------ACKSGPCIPN 372
             :.|.|:..|                           ::|...|..|        |.::...||:
  Fly   573 VNSSAEEGAGGPKGFVNFRDSKEIMMTSDSETKFKYSQRANRTSVKFSVSAPTTPAARTSSAIPS 637

  Fly   373 QWVCDGDSDCRNGEDEMQNCTVSLLNFCQAGEFQCSDRITCLHKSWVCDGEADCPDGEDESQSNC 437
            ..:      .:..|......|.|............:..||         .....|.....|:.|.
  Fly   638 SAL------VQQRERTTSTTTTSTTTSTTTSSITSTPSIT---------STTLIPINAATSEPNP 687

  Fly   438 LKV-----SCRPDQFQCNDQSCIAGHLTCNGKRDCADGSDEIMC-------------------DI 478
            .:|     .|.|.:.:|....||.....|:.:.||.|.:||:||                   ..
  Fly   688 YEVVTSLGGCPPQELRCVSGKCITVSQLCDKQIDCPDAADELMCVYRERPSRRRLTSTTAPPTTS 752

  Fly   479 SATPRTCNATT 489
            ||.|.|..|||
  Fly   753 SAPPETSTATT 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR2	NP_001097928.1	LDLa	193..224	CDD:197566	12/54 (22%)
		LDLa	235..267	CDD:197566	13/31 (42%)
		LDLa	277..313	CDD:238060	19/35 (54%)
		LDLa	356..388	CDD:197566	6/39 (15%)
		LDLa	400..432	CDD:197566	3/31 (10%)
		LDLa	442..476	CDD:238060	11/33 (33%)
		LDLa	484..517	CDD:197566	4/6 (67%)
		FXa_inhibition	527..562	CDD:291342
		EGF_CA	564..594	CDD:214542
		LY	675..715	CDD:214531
		LY	717..760	CDD:214531
		LY	763..803	CDD:214531
		FXa_inhibition	877..918	CDD:291342
CG6739	NP_609130.1	CRD_FZ	314..427	CDD:143549	19/131 (15%)
		LDLa	432..464	CDD:238060	14/31 (45%)
		LDLa	470..505	CDD:238060	19/35 (54%)
		LDLa	697..731	CDD:238060	11/33 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24270
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.000