Protein Alignment LpR2 and Lrp1b

DIOPT Version :10

• Sequence 1: NP_001097928.1
• Gene: LpR2 / 43105
• FlyBaseID: FBgn0051092
• Length: 1064
• Species: Drosophila melanogaster
• Sequence 2: XP_038962031.2
• Gene: Lrp1b / 311926
• RGDID: 1306160
• Length: 4668
• Species: Rattus norvegicus
• Alignment Length: 785
• Identity: 298/785 - (37%)
• Similarity: 411/785 - (52%)
• Gaps: 62/785 - (7%)

  Fly   162 NSVL--NGNPLKFLNVSGKIGTPLDISLGLSNYCDEKQFQCSTGECIPIRFVCDGSSDCPDHSDE 224
            |.:|  ||....|        .|.:|   :.:.|...:|:|....||..|:.|||..||.|.|||
  Rat   854 NQLLDENGTTCTF--------NPEEI---IFHICKPGEFRCKNKHCIQARWKCDGDDDCLDGSDE 907

  Fly   225 RLEECKFTESTCSQEQFRCGNGKCIPRRWVCDRENDCADGSDESTSQCRSHTCSPEEFACKSGEG 289
            ....| |..| |.::||:|.|.:|||:||:||..|||....|||...|.:.||..::|:|  |.|
  Rat   908 DSVTC-FNHS-CPEDQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTCTARTCQADQFSC--GNG 968

  Fly   290 ECIPLSWMCDQNKDCRDGSDE-AQCN-RTCRS-DEFTCGNGRCIQNRFKCDDDDDCGDGSDEKNC 351
            .|||.:|:||:..||.|.:|| ..|. .||.. .:|.|.:||||.|::.||.||||||.|||..|
  Rat   969 RCIPTAWVCDREDDCGDQTDEVTSCEFPTCEPLTQFLCKSGRCISNKWHCDTDDDCGDRSDEVGC 1033

  Fly   352 GEKAKCGSNFFACKSGPCIPNQWVCDGDSDCRNGEDEMQ-NCTVSLLNF---CQAGEFQCSDRIT 412
            ..  .|..:.|.|.||.|||..|.||||:||.:..||.. |||......   |...||||.....
  Rat  1034 VH--SCLDDQFRCASGRCIPGHWACDGDNDCGDFSDETHVNCTREEARSPVGCIGNEFQCHPDGN 1096

  Fly   413 CLHKSWVCDGEADCPDGEDESQSN-CLKVSCRPDQFQCNDQS-CIAGHLTCNGKRDCADGSDEIM 475
            |:...|.||||.||.||.||...| .:::.....:|.|.... ||.....|:|..||.|.|||..
  Rat  1097 CIPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCKSTGRCINNAWVCDGDVDCEDQSDEED 1161

  Fly   476 CD--ISATPRTCNATTEFDCGG--GLCIPNAKVCNRRKDCPNGEDEPAGKCGINECSSKNGGCMH 536
            ||  :...|:       :.|..  .:|:...|:||.|||||:|.|| ...|  :|||..||||.:
  Rat  1162 CDSFLCGPPK-------YPCANDTSVCLQPEKLCNGRKDCPDGSDE-GDLC--DECSLNNGGCSN 1216

  Fly   537 QC-VNLEVGYRCECHDGYKLGADQHTCVDIDECETPGICSQVCVNEIGAFKCECEAGYMRLLKNH 600
            .| |....|..|.|.:|::|..|..||..:|.|.:...|||||.......||.|..|:.......
  Rat  1217 HCSVVPGKGIVCSCPEGHQLKKDNRTCEIVDYCSSHLKCSQVCEQHKHMVKCSCYEGWALDTDGE 1281

  Fly   601 TRCKASEGHASLLLARRHDIRKIALDRPEMTSIVNSTKAATALDFVFRTGMIFWSDVATQSIYKA 665
            :........|.::.:.||:||:|.|.:.:.:.:|...:...||||.|...:::|:||....||:.
  Rat  1282 SCISVDSFEAFIIFSIRHEIRRIDLHKGDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRG 1346

  Fly   666 PIDEGNDRT---VVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIP 727
            .:.|....:   ||:.....|.:||.||||..::|:.|::...||::..:||:...|:..:::.|
  Rat  1347 KLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVSKLDGSLRATLIAGAMEHP 1411

  Fly   728 RSIALDPIEGWMYWSDWGAS-PRIERAGMDGTHRTAIITYDVK---WPNGITLDLVQKRLYWVDG 788
            |:|||||..|.::|:||.|: ||||.|.|.|..|..|.. |:|   ||||:|:|..::|:.|.|.
  Rat  1412 RAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYK-DMKTGAWPNGLTVDHFERRIVWTDA 1475

  Fly   789 KLNTISSSNYDGSQRHQVLYSGEYLRHPFSITTFEDYVYWTDWDKQAVFKANKFNGMDVEPVTAT 853
            :.:.|.|:.|||:...:::...|||.|||:::.:...||||||....:.||||:.|.:|..:..|
  Rat  1476 RSDAIYSAFYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLAKANKWTGQNVSVIQKT 1540

  Fly   854 HMLEHPMVVHVYHPYRQPDGVNHCQSVNGH--CSHLCLPAPRIN-ERSPRISCACPTGLKLMPDG 915
            .  ..|..:.:|||.|||...|.|.:..|.  ||||||    || .||  .:||||..:||..|.
  Rat  1541 S--AQPFDLQIYHPSRQPQAPNPCAANEGRGPCSHLCL----INHNRS--AACACPHLMKLSSDK 1597

  Fly   916 LMCVE 920
            ..|.|
  Rat  1598 KTCYE 1602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LpR2	NP_001097928.1	LDLa	193..224	CDD:197566	13/30 (43%)
		LDLa	235..267	CDD:197566	15/31 (48%)
		LDLa	277..313	CDD:238060	16/36 (44%)
		LDLa	356..388	CDD:197566	15/31 (48%)
		LDLa	400..432	CDD:197566	15/31 (48%)
		LDLa	442..476	CDD:238060	12/34 (35%)
		LDLa	484..517	CDD:197566	11/34 (32%)
		FXa_inhibition	527..562	CDD:464251	14/35 (40%)
		EGF_CA	564..594	CDD:214542	11/29 (38%)
		LY	675..715	CDD:214531	14/39 (36%)
		LY	717..760	CDD:214531	20/43 (47%)
		LY	763..803	CDD:214531	17/42 (40%)
		Ldl_recept_b	782..828	CDD:459654	15/45 (33%)
		Ldl_recept_b	824..866	CDD:459654	14/41 (34%)
		FXa_inhibition	877..918	CDD:464251	19/43 (44%)
Lrp1b	XP_038962031.2	None