DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LpR2 and Ldlr

DIOPT Version :9

Sequence 1:	NP_001097928.1	Gene:	LpR2 / 43105	FlyBaseID:	FBgn0051092	Length:	1064	Species:	Drosophila melanogaster
Sequence 2:	NP_786938.2	Gene:	Ldlr / 300438	RGDID:	2998	Length:	879	Species:	Rattus norvegicus

Alignment Length:	860	Identity:	354/860 - (41%)
Similarity:	492/860 - (57%)	Gaps:	65/860 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 ESTCSQEQFRCGNGKCIPRRWVCDRENDCADGSDESTSQCRSHTCSPEEFACKSGEGECIPLSWM 297
            |.:|.:.:|:|.:||||..:||||...:|.||||||...|.|.||...||:|......|||.||.
  Rat    24 EDSCGKNEFQCRDGKCIVSKWVCDGSRECPDGSDESPETCMSVTCRSGEFSCGGRVSRCIPDSWR 88

  Fly   298 CDQNKDCRDGSDEAQCN-RTCRSDEFTCGNGRCIQNRFKCDDDDDCGDGSDEKNCGEKAKCGSNF 361
            ||...||.:||||..|: :||..|||.|.:|:||..:|.||.|.||.|||||.:|. ...||...
  Rat    89 CDGRTDCENGSDELDCSPKTCSLDEFRCQDGKCISRQFVCDQDWDCLDGSDEAHCA-ATTCGPAH 152

  Fly   362 FACKSGPCIPNQWVCDGDSDCRNGEDEM-QNC--------TVSLLNFCQAGEFQCSDRITCLHKS 417
            |.|.|..|||:.|.||||.||.:|.||. |||        .||  :.|.:.||.|... .|:|:|
  Rat   153 FRCNSSSCIPSLWACDGDRDCDDGSDEWPQNCGGRDTAAEVVS--SPCSSLEFHCGSS-ECIHRS 214

  Fly   418 WVCDGEADCPDGEDESQSNCLKVSCRPDQFQCNDQSCIAGHLTCNGKRDCADGSDEIMCDISATP 482
            |||||.|||.|..||  .||...:||||:|||.|.|||.|...|:.:.||.|.|||:.| |:.|
  Rat   215 WVCDGAADCKDKSDE--ENCAVTTCRPDEFQCADGSCIHGSRQCDREHDCKDMSDELGC-INVT- 275

  Fly   483 RTCNATTEFDCGGGLCIPNAKVCNRRKDCPNGEDEPAGKCGINECSSKNGGCMHQCVNLEVGYRC 547
             .|:...:|.|..|.||...||||..:||.:..|||..:|..|||...||||.|.|.:|::||.|
  Rat   276 -QCDGPNKFKCHSGECISLDKVCNSARDCRDWSDEPIKECKTNECLDNNGGCSHICKDLKIGYEC 339

  Fly   548 ECHDGYKLGADQHTCVDIDECETPGICSQVCVNEIGAFKCECEAGYMRLLKNHTR-CKASEGHAS 611
            .|..|::| .|.|.|.|||||:.|..|||:|||..|:|||||.||:.  :..||| |||......
  Rat   340 LCPSGFRL-VDGHQCEDIDECQEPDTCSQLCVNLEGSFKCECRAGFH--MDPHTRVCKAVGSIGF 401

  Fly   612 LLLARRHDIRKIALDRPEMTSIVNSTKAATALDFVFRTGMIFWSDVATQSIYKAPIDEGNDRT-- 674
            ||...||::||:.|||.|.||::.:.|...|||.......|:|||::.:.||.|.:|:|...:
  Rat   402 LLFTNRHEVRKMTLDRSEYTSLIPNLKNVVALDTEVANNRIYWSDLSQRKIYSAVMDQGTSLSYD 466

  Fly   675 VVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWM 739
            .:::......||||||||:.::|:||:...|:.:.:.:|...:.|.::....||:|.:||:.|:|
  Rat   467 AIISGDLHAPDGLAVDWIHGNIYWTDSVPGTVSVADTKGVRRRTLFREKGSRPRAIVVDPVHGFM 531

  Fly   740 YWSDWGASPRIERAGMDGTHRTAIITYDVKWPNGITLDLVQKRLYWVDGKLNTISSSNYDGSQRH 804
            ||:|||...:|::.|::|....:::|.|::|||||||||...||||||.||::|||.:.:|..|.
  Rat   532 YWTDWGTPAKIKKGGLNGVDIYSLVTEDIQWPNGITLDLPSGRLYWVDSKLHSISSIDVNGGGRK 596

  Fly   805 QVLYSGEYLRHPFSITTFEDYVYWTDWDKQAVFKANKFNGMDVEPVTATHMLEHPMVVHVYHPYR 869
            .:|...:.|.||||:..:||.|||||...:|:|.||:..|.||..|...  |..|..:.::|...
  Rat   597 TILEDEKQLAHPFSLAIYEDKVYWTDVLNEAIFSANRLTGSDVNLVAKN--LMSPEDIVLFHNVT 659

  Fly   870 QPDGVNHCQSV---NGHCSHLCLPAPRINERSPRISCACPTGLKLMPDGLMCVEDLG-IPTVRPT 930
            ||.|||.|::.   ||.|.::|||||:|:..||:.:||||.|:.|..|...|:.::. :||.:.|
  Rat   660 QPRGVNWCEATVLPNGGCQYMCLPAPQISAHSPKFTCACPDGMLLAKDMRSCLPEVDTVPTTQGT 724

  Fly   931 APMHRTIEQSSNSTTKLPQD-------------GYSETPVETKTGNNRTDT-----------SNQ 971
            :.:...:..|:..:.|..:|             .:.|.|..|.|.....||           |:|
  Rat   725 STIGPVVTTSAAVSLKRKEDPSATRHKEDPSATRHKEDPSATSTSRQPGDTPELSTVESVTVSSQ 789

  Fly   972 VHKSDAESENDYVEIALHVIASLA---GTALVASVIY---VVYRRC-TRAVNSMNFENPVYHKTT 1029
            | :.|.....|  |:..|.:..|:   ..||||.:::   :::|.. .|.:||:||:||||.|||
  Rat   790 V-QGDMAGRGD--EVQRHGVGFLSIFLPIALVALLVFGAILLWRNWRLRNINSINFDNPVYQKTT 851

  Fly  1030 EDHFSLEKNGTPHIY 1044
            ||...:.::...:.|
  Rat   852 EDEIHICRSQDGYTY 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR2	NP_001097928.1	LDLa	193..224	CDD:197566
		LDLa	235..267	CDD:197566	15/31 (48%)
		LDLa	277..313	CDD:238060	17/35 (49%)
		LDLa	356..388	CDD:197566	16/31 (52%)
		LDLa	400..432	CDD:197566	16/31 (52%)
		LDLa	442..476	CDD:238060	19/33 (58%)
		LDLa	484..517	CDD:197566	12/32 (38%)
		FXa_inhibition	527..562	CDD:291342	16/34 (47%)
		EGF_CA	564..594	CDD:214542	20/29 (69%)
		LY	675..715	CDD:214531	13/39 (33%)
		LY	717..760	CDD:214531	16/42 (38%)
		LY	763..803	CDD:214531	23/39 (59%)
		FXa_inhibition	877..918	CDD:291342	19/43 (44%)
Ldlr	NP_786938.2	Ldl_recept_a	25..58	CDD:395011	15/32 (47%)
		Ldl_recept_a	66..104	CDD:395011	18/37 (49%)
		Ldl_recept_a	107..143	CDD:395011	20/35 (57%)
		Ldl_recept_a	196..232	CDD:395011	18/38 (47%)
		Ldl_recept_a	235..271	CDD:395011	19/35 (54%)
		Ldl_recept_a	279..309	CDD:395011	11/29 (38%)
		FXa_inhibition	319..353	CDD:405372	16/34 (47%)
		EGF_CA	355..389	CDD:214542	20/35 (57%)
		LDL-receptor class B 1	398..439		16/40 (40%)
		NHL	<435..628	CDD:302697	75/192 (39%)
		NHL repeat	435..469	CDD:271320	9/33 (27%)
		LDL-receptor class B 2	440..485		16/44 (36%)
		NHL repeat	476..514	CDD:271320	14/37 (38%)
		LDL-receptor class B 3	486..528		11/41 (27%)
		LDL-receptor class B 4	529..572		21/42 (50%)
		Ldl_recept_b	529..569	CDD:395012	18/39 (46%)
		NHL repeat	555..600	CDD:271320	24/44 (55%)
		LDL-receptor class B 5	573..615		19/41 (46%)
		NHL repeat	606..628	CDD:271320	11/21 (52%)
		LDL-receptor class B 6	616..658		17/43 (40%)
		Ldl_recept_b	616..655	CDD:395012	16/40 (40%)
		FXa_inhibition	674..711	CDD:405372	18/36 (50%)
		Clustered O-linked oligosaccharides	717..788		12/70 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	718..797		16/79 (20%)
		Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000250\|UniProtKB:P01130	830..879		16/37 (43%)
		NPXY motif. /evidence=ECO:0000250\|UniProtKB:P01130	842..847		3/4 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I10838
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	710	1.000	Inparanoid score	I619
OMA	1	1.010	-	-		QHG49125
OrthoDB	1	1.010	-	-		D179614at33208
OrthoFinder	1	1.000	-	-		FOG0002088
OrthoInspector	1	1.000	-	-		mtm9029
orthoMCL	1	0.900	-	-		OOG6_103130
Panther	1	1.100	-	-	LDO	PTHR24270
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1052
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880