DRSC/TRiP Functional Genomics Resources

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Protein Alignment LpR2 and Lrp1

DIOPT Version :9

Sequence 1:NP_001097928.1 Gene:LpR2 / 43105 FlyBaseID:FBgn0051092 Length:1064 Species:Drosophila melanogaster
Sequence 2:XP_008763615.1 Gene:Lrp1 / 299858 RGDID:1307535 Length:4562 Species:Rattus norvegicus


Alignment Length:824 Identity:300/824 - (36%)
Similarity:424/824 - (51%) Gaps:114/824 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   195 EKQFQCSTGECIPIRFVCDGSSDCPDHSDER-----LEECKFT---------------------- 232
            :.:|:|:.||||.....|||.|.|.|.|||:     ...||.|                      
  Rat  2545 QDEFECANGECISFSLTCDGVSHCKDKSDEKPSYCNSRRCKKTFRQCNNGRCVSNMLWCNGVDDC 2609

  Fly   233 ----------ESTCSQEQFRCGNGKCIPR------------------------------------ 251
                      ::.|...:|||.:|.||..                                    
  Rat  2610 GDGSDEIPCNKTACGVGEFRCRDGSCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVL 2674

  Fly   252 -------------RWVCDRENDCADGSDESTSQC---RSHTCSPEEFACKSGEGECIPLSWMCDQ 300
                         .||||..|||.|.|||  ..|   :...|....|||.|  |.|||:||.||:
  Rat  2675 FQPCERTSLCYAPSWVCDGANDCGDYSDE--RDCPGVKRPRCPLNYFACPS--GRCIPMSWTCDK 2735

  Fly   301 NKDCRDGSDEAQCNRTCRSDEFTCGNGRCIQNRFKCDDDDDCGDGSDEKNCGEKAKCGSNFFACK 365
            ..||.:|.||..||:.|...:|.|.|.|||..::.||..|||||||||....|...||.:.|:|.
  Rat  2736 EDDCENGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCP 2800

  Fly   366 -SGPCIPNQWVCDGDSDCRNGEDEMQNCTVSLLNFCQAGEFQCSDRITCLHKSWVCDGEADCPDG 429
             :..|:|.:|:||||.||.:|.||..:......:.|...||.|.:|: |:.|.:|||.:.||.||
  Rat  2801 GTHVCVPERWLCDGDKDCADGADESISAGCLYNSTCDDREFMCQNRL-CIPKHFVCDHDRDCADG 2864

  Fly   430 EDESQSNCLKVSCRPDQFQCNDQSCIAG-HLTCNGKRDCADGSDEIMCDISAT--PRTCNATTEF 491
            .||| ..|...:|.|::|:|.:..|::. ...|:|:.||.|.|||...:...|  ...|||:::|
  Rat  2865 SDES-PECEYPTCGPNEFRCANGRCLSSRQWECDGENDCHDHSDEAPKNPHCTSPEHKCNASSQF 2928

  Fly   492 DCGGGLCIPNAKVCNRRKDCPNGEDEPAGKCGINEC-SSKNGGCMHQCVNLEVGYRCECHDGYKL 555
            .|..|.|:..|.:||.:.||.:|.||..  |.:||| |.|..||...|.:|::|::|.|..|::|
  Rat  2929 LCSSGRCVAEALLCNGQDDCGDGSDERG--CHVNECLSRKLSGCSQDCEDLKIGFKCRCRPGFRL 2991

  Fly   556 GADQHTCVDIDECETPGICSQVCVNEIGAFKCECEAGYMRLLKNHTRCKA-SEGHASLLLARRHD 619
            ..|..||.|:|||.|...|||:|:|..|::||.|..||.....:...||| ::....|:.|.|:.
  Rat  2992 KDDGRTCADVDECSTTFPCSQLCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYY 3056

  Fly   620 IRKIALDRPEMTSIVNSTKAATALDFVFRTGMIFWSDVATQSIYKAPIDEGNDRTVVLTKSSVTS 684
            :||:.||....|.:......|.||||.:|..||:|:||.||......:........||.::.:::
  Rat  3057 LRKLNLDGSNYTLLKQGLNNAVALDFDYRGQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSN 3121

  Fly   685 -DGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGASP 748
             |||||||:..::|:.|..:.|||::...|:...|||...|..||::.:|...|::||:|||...
  Rat  3122 PDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHS 3186

  Fly   749 RIERAGMDGTHRTAIITYDVKWPNGITLDLVQKRLYWVDGKLNTISSSNYDGSQRHQVLYSGEYL 813
            .|.|.||||:.|:.|:...:.||||:|:|.|.:|:||.|.:.:.|..::.|||.||.||  .:.:
  Rat  3187 LIGRIGMDGSGRSIIVDTKITWPNGLTVDYVTERIYWADAREDYIEFASLDGSNRHVVL--SQDI 3249

  Fly   814 RHPFSITTFEDYVYWTDWDKQAVFKANKFNGMDVEPVTATHMLEHPMVVHVYHPYRQPDGVNH-C 877
            .|.|::|.||||||||||:.:::.:|:|..|.:...:.:|  |..||.:||:|..||||..|| |
  Rat  3250 PHIFALTLFEDYVYWTDWETKSINRAHKTTGANKTLLIST--LHRPMDLHVFHALRQPDVPNHPC 3312

  Fly   878 QSVNGHCSHLCLPAPRINERSPRISCACPTGLKLMPDGLMCVED 921
            :..||.||:|||.:|....:     |||||...|..||..||.:
  Rat  3313 KVNNGGCSNLCLLSPGGGHK-----CACPTNFYLGGDGRTCVSN 3351

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LpR2NP_001097928.1 LDLa 193..224 CDD:197566 13/28 (46%)
LDLa 235..267 CDD:197566 16/80 (20%)
LDLa 277..313 CDD:238060 18/35 (51%)
LDLa 356..388 CDD:197566 14/32 (44%)
LDLa 400..432 CDD:197566 14/31 (45%)
LDLa 442..476 CDD:238060 13/34 (38%)
LDLa 484..517 CDD:197566 13/32 (41%)
FXa_inhibition 527..562 CDD:291342 13/35 (37%)
EGF_CA 564..594 CDD:214542 15/29 (52%)
LY 675..715 CDD:214531 15/40 (38%)
LY 717..760 CDD:214531 19/42 (45%)
LY 763..803 CDD:214531 16/39 (41%)
FXa_inhibition 877..918 CDD:291342 17/40 (43%)
Lrp1XP_008763615.1 LDLa 27..60 CDD:197566
LDLa 72..105 CDD:197566
FXa_inhibition 120..149 CDD:291342
FXa_inhibition 161..189 CDD:291342
LY 276..315 CDD:214531
LY 317..359 CDD:214531
LY 362..402 CDD:214531
FXa_inhibition 487..520 CDD:291342
LY 552..594 CDD:214531
LY 595..634 CDD:214531
LY 641..690 CDD:214531
LY <701..734 CDD:214531
FXa_inhibition 808..843 CDD:291342
LDLa 854..886 CDD:197566
LDLa 896..929 CDD:238060
LDLa 936..968 CDD:197566
LDLa 979..1012 CDD:238060
LDLa 1033..1066 CDD:238060
LDLa 1080..1115 CDD:238060
LDLa 1122..1158 CDD:238060
LDLa 1163..1196 CDD:238060
FXa_inhibition 1203..1239 CDD:291342
LY 1354..1394 CDD:214531
LY 1398..1441 CDD:214531
LY 1442..1486 CDD:214531
LY 1631..1667 CDD:214531
LY 1668..1711 CDD:214531
LY 1715..1752 CDD:214531
LY 1752..1793 CDD:214531
FXa_inhibition 1868..1904 CDD:291342
LY 1934..1974 CDD:214531
LY 1977..2017 CDD:214531
LY 2018..2061 CDD:214531
LY 2063..2105 CDD:214531
FXa_inhibition 2177..2212 CDD:291342
YvrE 2271..2481 CDD:225921
Ldl_recept_b 2362..2403 CDD:278487
LY 2388..2429 CDD:214531
FXa_inhibition 2500..2532 CDD:291342
LDLa 2545..2575 CDD:238060 14/29 (48%)
LDLa 2584..2618 CDD:238060 3/33 (9%)
LDLa 2623..2657 CDD:238060 7/33 (21%)
LDLa <2684..2706 CDD:238060 11/23 (48%)
LDLa 2714..2748 CDD:238060 18/35 (51%)
LDLa 2752..2783 CDD:197566 16/30 (53%)
LDLa 2791..2824 CDD:197566 14/32 (44%)
LDLa 2835..2867 CDD:197566 14/32 (44%)
LDLa 2875..2908 CDD:197566 11/32 (34%)
LDLa 2925..2957 CDD:238060 12/33 (36%)
cEGF 2980..3003 CDD:289433 9/22 (41%)
EGF_CA 3000..>3029 CDD:214542 14/28 (50%)
LY 3067..3111 CDD:214531 14/43 (33%)
LY 3112..3154 CDD:214531 15/41 (37%)
LY 3156..3198 CDD:214531 19/41 (46%)
LY 3200..3241 CDD:214531 16/40 (40%)
LY 3242..3282 CDD:214531 19/41 (46%)
FXa_inhibition 3312..3348 CDD:291342 17/40 (43%)
LDLa 3352..3383 CDD:238060 300/824 (36%)
LDLa 3392..3426 CDD:238060
LDLa 3431..3466 CDD:238060
LDLa 3470..3503 CDD:197566
LDLa 3511..3544 CDD:197566
LDLa 3554..3588 CDD:238060
LDLa 3593..3627 CDD:238060
LDLa 3631..3665 CDD:238060
LDLa 3671..3703 CDD:197566
LDLa 3713..3749 CDD:238060
LDLa 3764..3794 CDD:238060
LY 3973..4010 CDD:214531
Ldl_recept_b 4031..4071 CDD:278487
LY 4055..4096 CDD:214531
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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